Published in J Immunol on June 15, 2008
Microbes in gastrointestinal health and disease. Gastroenterology (2008) 4.65
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis (2010) 2.26
Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol (2014) 2.11
Structural basis of TLR5-flagellin recognition and signaling. Science (2012) 2.10
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06
Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis (2010) 1.79
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med (2015) 1.75
Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis. Infect Immun (2011) 1.53
Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol (2014) 1.52
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (2010) 1.43
Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. PLoS One (2016) 1.40
Trial Watch: Anticancer radioimmunotherapy. Oncoimmunology (2013) 1.31
Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases. Front Immunol (2013) 1.27
Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner. Gut (2011) 1.26
After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol (2011) 1.24
Links between innate immunity and normal tissue radiobiology. Radiat Res (2010) 1.19
Host defense at the ocular surface. Int Rev Immunol (2013) 1.16
Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol (2010) 1.15
Assessment of biodosimetry methods for a mass-casualty radiological incident: medical response and management considerations. Health Phys (2013) 1.14
Pathogen recognition receptors, cancer and inflammation in the gut. Curr Opin Pharmacol (2009) 1.14
Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science (2014) 1.12
Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. J Pharmacol Exp Ther (2012) 1.09
Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets (2010) 1.03
Radiation countermeasure agents: an update (2011-2014). Expert Opin Ther Pat (2014) 1.02
The application of Toll like receptors for cancer therapy. Int J Biol Sci (2010) 1.01
Innate immune signaling in defense against intestinal microbes. Immunol Rev (2012) 1.00
The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol (2013) 1.00
Topical flagellin protects the injured corneas from Pseudomonas aeruginosa infection. Microbes Infect (2010) 0.99
Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun (2013) 0.99
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med (2011) 0.98
Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway. PLoS One (2010) 0.96
Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis. Neurogastroenterol Motil (2010) 0.95
Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. J Immunol (2011) 0.93
HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. PLoS One (2012) 0.93
Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease. Cell Mol Gastroenterol Hepatol (2016) 0.92
Toll-like receptors and human disease: lessons from single nucleotide polymorphisms. Curr Genomics (2012) 0.92
Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile. Health Phys (2015) 0.91
Trial Watch: Radioimmunotherapy for oncological indications. Oncoimmunology (2014) 0.91
Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism. Am J Physiol Gastrointest Liver Physiol (2011) 0.91
Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice. Cell Mol Immunol (2014) 0.90
A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance. Cell Death Dis (2013) 0.87
Basic and translational understandings of microbial recognition by toll-like receptors in the intestine. J Neurogastroenterol Motil (2011) 0.87
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity. Cancer Res (2015) 0.87
Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? Curr Opin Support Palliat Care (2012) 0.87
TLR signaling modulates side effects of anticancer therapy in the small intestine. J Immunol (2015) 0.86
MyD88 provides a protective role in long-term radiation-induced lung injury. Int J Radiat Biol (2012) 0.85
A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections. Antimicrob Agents Chemother (2015) 0.85
Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses. Antimicrob Agents Chemother (2011) 0.85
New approaches to radiation protection. Front Oncol (2015) 0.85
Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components. Mucosal Immunol (2010) 0.83
Role of gut microbiota in early infant development. Clin Med Pediatr (2009) 0.82
Suppression of radiation-induced DNA double-strand break repair by MyD88 is accompanied by apoptosis and crypt loss in mouse colon. Oncogenesis (2013) 0.81
Genome-wide transcriptional analysis of differentially expressed genes in flagellin-pretreated mouse corneal epithelial cells in response to Pseudomonas aeruginosa: involvement of S100A8/A9. Mucosal Immunol (2013) 0.81
Modifying radiation damage. Curr Drug Targets (2010) 0.81
A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. PLoS One (2013) 0.81
Toll-like receptor 5 engagement induces interleukin-17C expression in intestinal epithelial cells. J Interferon Cytokine Res (2012) 0.81
Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells. PLoS One (2012) 0.80
The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLoS One (2015) 0.80
Interferon regulatory factor-1 in flagellin-induced reprogramming: potential protective role of CXCL10 in cornea innate defense against Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci (2013) 0.80
Complete Genome Sequence of the Human Gut Symbiont Roseburia hominis. Genome Announc (2015) 0.79
rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner. Cell Mol Immunol (2013) 0.79
A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance. Sci Rep (2015) 0.79
CpG-Oligodeoxynucleotide Treatment Protects against Ionizing Radiation-Induced Intestine Injury. PLoS One (2013) 0.78
Radiation takes its Toll. Cancer Lett (2015) 0.78
Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine. Front Cell Infect Microbiol (2016) 0.78
Reevaluating the hype: four bacterial metabolites under scrutiny. Eur J Microbiol Immunol (Bp) (2015) 0.77
Combining flagellin and human β-defensin-3 to combat bacterial infections. Front Microbiol (2014) 0.77
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis. Invest Ophthalmol Vis Sci (2017) 0.77
Antibodies against Marinobacter algicola and Salmonella typhimurium flagellins do not cross-neutralize TLR5 activation. PLoS One (2012) 0.76
Cloning of fliC Gene From Salmonella typhimurium in the Expression Vector pVAX1 and Evaluation of its Expression in Eukaryotic Cells. Jundishapur J Microbiol (2014) 0.76
Matrix Metalloproteinase-13 as a Target for Suppressing Corneal Ulceration Caused by Pseudomonas aeruginosa Infection. J Infect Dis (2015) 0.76
Flagellin-mediated protection against intestinal Yersinia pseudotuberculosis infection does not require interleukin-22. Infect Immun (2016) 0.75
Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms. Nucleic Acids Res (2016) 0.75
Flagellin as carrier and adjuvant in cocaine vaccine development. Mol Pharm (2015) 0.75
Bacterial ghosts as adjuvants: mechanisms and potential. Vet Res (2017) 0.75
Intestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-α, contributing to epithelial barrier dysfunction. Am J Physiol Gastrointest Liver Physiol (2014) 0.75
Bacterial flagellin-a potent immunomodulatory agent. Exp Mol Med (2017) 0.75
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11
Nosocomial transmission of human granulocytic anaplasmosis in China. JAMA (2008) 5.01
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol (2005) 4.57
Ipr1 gene mediates innate immunity to tuberculosis. Nature (2005) 4.53
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol (2007) 3.67
Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis (2006) 3.65
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56
Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 3.52
Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol (2010) 3.10
Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05
Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol (2007) 2.88
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol (2002) 2.70
Food markets with live birds as source of avian influenza. Emerg Infect Dis (2006) 2.55
Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis. J Infect Dis (2009) 2.49
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48
Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLoS One (2009) 2.38
Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis (2011) 2.34
Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med (2005) 2.33
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32
The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol (2011) 2.23
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22
Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 2.15
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06
Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol (2010) 2.05
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. Am J Respir Crit Care Med (2007) 2.05
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology (2005) 2.03
Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol (2002) 1.95
Spontaneous spinal epidural hematoma: analysis of 23 cases. Surg Neurol (2007) 1.94
Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol (2005) 1.93
Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol (2004) 1.91
Derivation of Escherichia coli O157:H7 from its O55:H7 precursor. PLoS One (2010) 1.90
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One (2012) 1.90
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86
The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation. J Immunol (2009) 1.78
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77
Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Respir Cell Mol Biol (2006) 1.75
A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors. Proc Natl Acad Sci U S A (2014) 1.75
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade. Cell Host Microbe (2008) 1.69
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res (2009) 1.67
Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc (2011) 1.66
Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China. Emerg Infect Dis (2004) 1.65
Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A (2004) 1.63
Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Am J Respir Cell Mol Biol (2007) 1.61
Bacterial activation of beta-catenin signaling in human epithelia. Am J Physiol Gastrointest Liver Physiol (2004) 1.60
Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest (2010) 1.59
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics (2007) 1.59
Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies. Expert Opin Biol Ther (2008) 1.59
Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog (2013) 1.58
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57
Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis (2007) 1.57
Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. Am J Physiol Lung Cell Mol Physiol (2005) 1.56
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol (2006) 1.54
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology (2012) 1.52
Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol (2006) 1.52
Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol (2014) 1.52
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem (2005) 1.52
Identification of a new Neisseria meningitidis serogroup C clone from Anhui province, China. Lancet (2006) 1.50
Reducing exposure to avian influenza H7N9. Lancet (2013) 1.50
TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J Immunol (2006) 1.50
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.49
Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest (2007) 1.47
Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2011) 1.47
Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract. J Virol (2009) 1.47
Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radic Biol Med (2009) 1.45
Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol (2006) 1.45
IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol (2003) 1.42
Scrub typhus in previously unrecognized areas of endemicity in China. J Clin Microbiol (2010) 1.41
Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol (2004) 1.41
Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1. J Immunol (2005) 1.40
Intracystic bleomycin for cystic craniopharyngiomas in children (abridged republication of cochrane systematic review). Neurosurgery (2012) 1.39
Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids. PLoS One (2013) 1.39
Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian. Gastroenterology (2011) 1.39
Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited. Annu Rev Pathol (2013) 1.38
Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annu Rev Physiol (2011) 1.38
In"sight" into immune blindness: Helicobacter pylori-induced gastritis requires T cells primed in the small intestine Peyer's patches. Gastroenterology (2007) 1.38
TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol (2003) 1.38