Published in Biophys J on April 02, 2013
Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A (2013) 1.05
Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance. Proc Natl Acad Sci U S A (2014) 0.90
Identifying and quantitating conformational exchange in membrane proteins using site-directed spin labeling. Acc Chem Res (2014) 0.84
The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Proc Natl Acad Sci U S A (2014) 0.79
Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex. Structure (2016) 0.78
Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts. Phys Chem Chem Phys (2016) 0.76
Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly. IUCrJ (2014) 0.75
Critical role of β1 integrin in postnatal beta-cell function and expansion. Oncotarget (2017) 0.75
Reconstitution of calcium-mediated exocytosis of dense-core vesicles. Sci Adv (2017) 0.75
The Xplor-NIH NMR molecular structure determination package. J Magn Reson (2003) 16.23
SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol (2006) 12.74
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96
Dead-time free measurement of dipole-dipole interactions between electron spins. J Magn Reson (2000) 5.26
A new spin on protein dynamics. Trends Biochem Sci (2002) 3.72
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives. Proc Natl Acad Sci U S A (2000) 2.72
Effective rotational correlation times of proteins from NMR relaxation interference. J Magn Reson (2005) 2.37
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33
Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit (2010) 2.31
Structural analysis of the neuronal SNARE protein syntaxin-1A. Biochemistry (2000) 2.30
SNAREs and traffic. Biochim Biophys Acta (2005) 2.22
Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1. Proc Natl Acad Sci U S A (2003) 2.18
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci (2007) 2.01
Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA. Biochemistry (2004) 2.00
Munc18-1 in secretion: lonely Munc joins SNARE team and takes control. Trends Neurosci (2007) 1.96
Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci (2007) 1.87
Protein hydration, thermodynamic binding, and preferential hydration. Biochemistry (2002) 1.81
At the junction of SNARE and SM protein function. Curr Opin Cell Biol (2010) 1.65
Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling. J Biol Chem (2001) 1.63
Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci (2009) 1.60
Assessing oligomerization of membrane proteins by four-pulse DEER: pH-dependent dimerization of NhaA Na+/H+ antiporter of E. coli. Biophys J (2005) 1.24
An analysis of the molecular origin of osmolyte-dependent protein stability. Protein Sci (2007) 1.23
NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR (2008) 1.19
Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol (2009) 1.17
Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J (2012) 1.11
Capillarity theory for the fly-casting mechanism. Proc Natl Acad Sci U S A (2010) 1.11
Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proc Natl Acad Sci U S A (2012) 1.08
High-pressure EPR reveals conformational equilibria and volumetric properties of spin-labeled proteins. Proc Natl Acad Sci U S A (2011) 1.07
Membrane topologies of neuronal SNARE folding intermediates. Biochemistry (2002) 0.99
Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins. Protein Sci (2010) 0.97
Recent advances and applications of site-directed spin labeling. Curr Opin Struct Biol (2006) 3.12
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J (2004) 2.66
NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell (2008) 1.92
Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling. Biochemistry (2002) 1.57
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proc Natl Acad Sci U S A (2009) 1.57
Position of synaptotagmin I at the membrane interface: cooperative interactions of tandem C2 domains. Biochemistry (2006) 1.54
Membrane-bound orientation and position of the synaptotagmin I C2A domain by site-directed spin labeling. Biochemistry (2003) 1.47
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (2007) 1.36
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers. J Biol Chem (2002) 1.34
Substrate-induced conformational changes of the periplasmic N-terminus of an outer-membrane transporter by site-directed spin labeling. Biochemistry (2003) 1.31
Spectroscopic evidence that osmolytes used in crystallization buffers inhibit a conformation change in a membrane protein. Biochemistry (2003) 1.30
Membrane-bound orientation and position of the synaptotagmin C2B domain determined by site-directed spin labeling. Biochemistry (2005) 1.27
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance. Biochemistry (2006) 1.20
Solutes modify a conformational transition in a membrane transport protein. Biophys J (2006) 1.20
Structure and dynamics of the beta-barrel of the membrane transporter BtuB by site-directed spin labeling. Biochemistry (2002) 1.18
Conformational exchange in a membrane transport protein is altered in protein crystals. Biophys J (2010) 1.17
Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol (2009) 1.17
Solutes alter the conformation of the ligand binding loops in outer membrane transporters. Biochemistry (2007) 1.12
Differential substrate-induced signaling through the TonB-dependent transporter BtuB. Proc Natl Acad Sci U S A (2003) 1.08
Location of the myristoylated alanine-rich C-kinase substrate (MARCKS) effector domain in negatively charged phospholipid bicelles. Biophys J (2003) 1.08
Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. Biochemistry (2011) 1.06
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (2012) 1.06
The calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding. J Mol Biol (2009) 1.05
Competing ligands stabilize alternate conformations of the energy coupling motif of a TonB-dependent outer membrane transporter. Proc Natl Acad Sci U S A (2003) 1.02
Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proc Natl Acad Sci U S A (2013) 1.02
Substrate-dependent transmembrane signaling in TonB-dependent transporters is not conserved. Proc Natl Acad Sci U S A (2007) 0.99
Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling. Biochemistry (2008) 0.98
Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous. J Mol Biol (2010) 0.98
Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins. Protein Sci (2010) 0.97
Molecular origin of electron paramagnetic resonance line shapes on β-barrel membrane proteins: the local solvation environment modulates spin-label configuration. Biochemistry (2011) 0.96
Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine. J Biol Chem (2011) 0.95
Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation. J Med Chem (2002) 0.93
Membrane hydrocarbon thickness modulates the dynamics of a membrane transport protein. Biophys J (2008) 0.92
Membrane mimetic environments alter the conformation of the outer membrane protein BtuB. J Am Chem Soc (2003) 0.90
The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature. Biochemistry (2014) 0.88
Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases. Biochemistry (2011) 0.87
Ligand-induced structural changes in the Escherichia coli ferric citrate transporter reveal modes for regulating protein-protein interactions. J Mol Biol (2012) 0.84
Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex. Biochemistry (2013) 0.83
Membrane position of a basic aromatic peptide that sequesters phosphatidylinositol 4,5 bisphosphate determined by site-directed spin labeling and high-resolution NMR. Biophys J (2004) 0.83
Membrane thickness varies around the circumference of the transmembrane protein BtuB. Biophys J (2011) 0.82
Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach. Protein Sci (2009) 0.81
The N-terminal domain of a TonB-dependent transporter undergoes a reversible stepwise denaturation. Biochemistry (2012) 0.81
Closure of the cytoplasmic gate formed by TM5 and TM11 during transport in the oxalate/formate exchanger from Oxalobacter formigenes. Biochemistry (2014) 0.80
Molecular basis for substrate-dependent transmembrane signaling in an outer-membrane transporter. J Mol Biol (2007) 0.79
Intra and inter-molecular interactions dictate the aggregation state of irinotecan co-encapsulated with floxuridine inside liposomes. Pharm Res (2008) 0.79
Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. J Med Chem (2003) 0.78
Lipid and membrane mimetic environments modulate spin label side chain configuration in the outer membrane protein A. J Phys Chem B (2011) 0.78
Spin-diffusion couples proton relaxation rates for proteins in exchange with a membrane interface. J Magn Reson (2008) 0.76