Published in Proc Natl Acad Sci U S A on July 02, 2007
TonB-dependent transporters: regulation, structure, and function. Annu Rev Microbiol (2010) 2.72
Coordination chemistry of bacterial metal transport and sensing. Chem Rev (2009) 2.65
Conformational exchange in a membrane transport protein is altered in protein crystals. Biophys J (2010) 1.17
Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins. Protein Sci (2010) 0.97
TonB induces conformational changes in surface-exposed loops of FhuA, outer membrane receptor of Escherichia coli. Protein Sci (2008) 0.91
FhuA (TonA), the career of a protein. J Bacteriol (2009) 0.90
The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding. J Biol Chem (2014) 0.85
Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether. Protein Sci (2011) 0.84
Ligand-induced structural changes in the Escherichia coli ferric citrate transporter reveal modes for regulating protein-protein interactions. J Mol Biol (2012) 0.84
Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex. Biochemistry (2013) 0.83
Potential artifacts in using a glutathione S-transferase fusion protein system and spin labeling electron paramagnetic resonance methods to study protein-protein interactions. Anal Biochem (2008) 0.82
Characterization of the disordered-to-α-helical transition of IA₃ by SDSL-EPR spectroscopy. Protein Sci (2011) 0.81
New insights into iron acquisition by cyanobacteria: an essential role for ExbB-ExbD complex in inorganic iron uptake. ISME J (2014) 0.79
Continuous wave W- and D-band EPR spectroscopy offer "sweet-spots" for characterizing conformational changes and dynamics in intrinsically disordered proteins. Biochem Biophys Res Commun (2014) 0.78
Aberrantly large single-channel conductance of polyhistidine arm-containing protein nanopores. Biochemistry (2017) 0.75
Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63
Identifying conformational changes with site-directed spin labeling. Nat Struct Biol (2000) 5.76
Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide. Science (1998) 5.62
Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics. Biochemistry (1996) 5.52
Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36
A new spin on protein dynamics. Trends Biochem Sci (2002) 3.72
Structural basis of gating by the outer membrane transporter FecA. Science (2002) 3.40
Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell (1998) 3.27
Recent advances and applications of site-directed spin labeling. Curr Opin Struct Biol (2006) 3.12
Touch and go: tying TonB to transport. Mol Microbiol (2003) 2.72
Substrate-induced transmembrane signaling in the cobalamin transporter BtuB. Nat Struct Biol (2003) 2.41
Acquisition of siderophores in gram-negative bacteria. Nat Rev Mol Cell Biol (2003) 2.24
Coupling site-directed mutagenesis with high-level expression: large scale production of mutant porins from E. coli. FEMS Microbiol Lett (1998) 2.23
Outer membrane active transport: structure of the BtuB:TonB complex. Science (2006) 2.04
Structure of TonB in complex with FhuA, E. coli outer membrane receptor. Science (2006) 2.01
Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA. Biochemistry (2004) 2.00
Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry (2002) 1.99
Spin labeled cysteines as sensors for protein-lipid interaction and conformation in rhodopsin. Photochem Photobiol (1992) 1.96
Protein hydration, thermodynamic binding, and preferential hydration. Biochemistry (2002) 1.81
Site-directed disulfide bonding reveals an interaction site between energy-coupling protein TonB and BtuB, the outer membrane cobalamin transporter. Proc Natl Acad Sci U S A (1999) 1.80
TonB-dependent outer membrane transport: going for Baroque? Curr Opin Struct Biol (2005) 1.65
Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecA. J Mol Biol (2003) 1.63
Transcription induction of the ferric citrate transport genes via the N-terminus of the FecA outer membrane protein, the Ton system and the electrochemical potential of the cytoplasmic membrane. Mol Microbiol (1997) 1.63
Iron uptake by Escherichia coli. Front Biosci (2003) 1.53
Substrate-induced exposure of an energy-coupling motif of a membrane transporter. Nat Struct Biol (2000) 1.42
Substrate-induced conformational changes of the periplasmic N-terminus of an outer-membrane transporter by site-directed spin labeling. Biochemistry (2003) 1.31
Spectroscopic evidence that osmolytes used in crystallization buffers inhibit a conformation change in a membrane protein. Biochemistry (2003) 1.30
Cell envelope signaling in Escherichia coli. Ligand binding to the ferrichrome-iron receptor fhua promotes interaction with the energy-transducing protein TonB. J Biol Chem (1997) 1.26
Interactions between the outer membrane ferric citrate transporter FecA and TonB: studies of the FecA TonB box. J Bacteriol (2003) 1.21
Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance. Biochemistry (2006) 1.20
Solutes modify a conformational transition in a membrane transport protein. Biophys J (2006) 1.20
Mutual inhibition of cobalamin and siderophore uptake systems suggests their competition for TonB function. J Bacteriol (1995) 1.19
Structure and dynamics of the beta-barrel of the membrane transporter BtuB by site-directed spin labeling. Biochemistry (2002) 1.18
Differential substrate-induced signaling through the TonB-dependent transporter BtuB. Proc Natl Acad Sci U S A (2003) 1.08
Transport-defective mutations alter the conformation of the energy-coupling motif of an outer membrane transporter. Biochemistry (2001) 1.08
TonB of Escherichia coli activates FhuA through interaction with the beta-barrel. Microbiology (2002) 1.07
Mutant analysis of the Escherichia coli FhuA protein reveals sites of FhuA activity. J Bacteriol (2003) 1.01
Oligomeric states and siderophore binding of the ligand-gated FhuA protein that forms channels across Escherichia coli outer membranes. Eur J Biochem (1997) 1.00
Three paradoxes of ferric enterobactin uptake. Front Biosci (2003) 0.99
Kinetic analyses reveal multiple steps in forming TonB-FhuA complexes from Escherichia coli. Biochemistry (2005) 0.93
Membrane mimetic environments alter the conformation of the outer membrane protein BtuB. J Am Chem Soc (2003) 0.90
Recent advances and applications of site-directed spin labeling. Curr Opin Struct Biol (2006) 3.12
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J (2004) 2.66
NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell (2008) 1.92
Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling. Biochemistry (2002) 1.57
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proc Natl Acad Sci U S A (2009) 1.57
Position of synaptotagmin I at the membrane interface: cooperative interactions of tandem C2 domains. Biochemistry (2006) 1.54
Membrane-bound orientation and position of the synaptotagmin I C2A domain by site-directed spin labeling. Biochemistry (2003) 1.47
Drug pressure selected mutations in HIV-1 protease alter flap conformations. J Am Chem Soc (2009) 1.41
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (2007) 1.36
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers. J Biol Chem (2002) 1.34
Interflap distances in HIV-1 protease determined by pulsed EPR measurements. J Am Chem Soc (2007) 1.32
Substrate-induced conformational changes of the periplasmic N-terminus of an outer-membrane transporter by site-directed spin labeling. Biochemistry (2003) 1.31
Spectroscopic evidence that osmolytes used in crystallization buffers inhibit a conformation change in a membrane protein. Biochemistry (2003) 1.30
Membrane-bound orientation and position of the synaptotagmin C2B domain determined by site-directed spin labeling. Biochemistry (2005) 1.27
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance. Biochemistry (2006) 1.20
Solutes modify a conformational transition in a membrane transport protein. Biophys J (2006) 1.20
Structure and dynamics of the beta-barrel of the membrane transporter BtuB by site-directed spin labeling. Biochemistry (2002) 1.18
Monitoring inhibitor-induced conformational population shifts in HIV-1 protease by pulsed EPR spectroscopy. Biochemistry (2009) 1.18
Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol (2009) 1.17
Conformational exchange in a membrane transport protein is altered in protein crystals. Biophys J (2010) 1.17
Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility. J Am Chem Soc (2009) 1.13
Solutes alter the conformation of the ligand binding loops in outer membrane transporters. Biochemistry (2007) 1.12
Location of the myristoylated alanine-rich C-kinase substrate (MARCKS) effector domain in negatively charged phospholipid bicelles. Biophys J (2003) 1.08
Differential substrate-induced signaling through the TonB-dependent transporter BtuB. Proc Natl Acad Sci U S A (2003) 1.08
Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. Biochemistry (2011) 1.06
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (2012) 1.06
The calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding. J Mol Biol (2009) 1.05
Competing ligands stabilize alternate conformations of the energy coupling motif of a TonB-dependent outer membrane transporter. Proc Natl Acad Sci U S A (2003) 1.02
Solute effects on spin labels at an aqueous-exposed site in the flap region of HIV-1 protease. J Phys Chem B (2009) 1.02
Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proc Natl Acad Sci U S A (2013) 1.02
Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling. Biochemistry (2008) 0.98
Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous. J Mol Biol (2010) 0.98
Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates. Mol Microbiol (2012) 0.98
Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins. Protein Sci (2010) 0.97
Molecular origin of electron paramagnetic resonance line shapes on β-barrel membrane proteins: the local solvation environment modulates spin-label configuration. Biochemistry (2011) 0.96
Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine. J Biol Chem (2011) 0.95
Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation. J Med Chem (2002) 0.93
Membrane hydrocarbon thickness modulates the dynamics of a membrane transport protein. Biophys J (2008) 0.92
Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease. Biochemistry (2013) 0.92
Pulsed EPR distance measurements in soluble proteins by site-directed spin labeling (SDSL). Curr Protoc Protein Sci (2013) 0.90
Membrane mimetic environments alter the conformation of the outer membrane protein BtuB. J Am Chem Soc (2003) 0.90
The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature. Biochemistry (2014) 0.88
Correlating conformational shift induction with altered inhibitor potency in a multidrug resistant HIV-1 protease variant. Biochemistry (2012) 0.88
Allosteric control of syntaxin 1a by Munc18-1: characterization of the open and closed conformations of syntaxin. Biophys J (2013) 0.87
Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases. Biochemistry (2011) 0.87
Inhibitor-induced conformational shifts and ligand-exchange dynamics for HIV-1 protease measured by pulsed EPR and NMR spectroscopy. J Phys Chem B (2012) 0.84
Ligand-induced structural changes in the Escherichia coli ferric citrate transporter reveal modes for regulating protein-protein interactions. J Mol Biol (2012) 0.84
Characterizing the dynamics of the leader-linker interaction in the glycine riboswitch with site-directed spin labeling. Biochemistry (2014) 0.83
Sequential proteolysis and high-field FTICR MS to determine disulfide connectivity and 4-maleimide TEMPO spin-label location in L126C GM2 activator protein. Anal Chem (2009) 0.83
Membrane position of a basic aromatic peptide that sequesters phosphatidylinositol 4,5 bisphosphate determined by site-directed spin labeling and high-resolution NMR. Biophys J (2004) 0.83
Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex. Biochemistry (2013) 0.83
A dansyl fluorescence-based assay for monitoring kinetics of lipid extraction and transfer. Anal Biochem (2008) 0.83
Membrane thickness varies around the circumference of the transmembrane protein BtuB. Biophys J (2011) 0.82
Lipid polymorphism induced by surfactant peptide SP-B(1-25). Biophys J (2010) 0.82
Backbone ¹H, ¹³C, and ¹⁵N chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769. Biomol NMR Assign (2012) 0.82
Bis(monoacylglycero)phosphate forms stable small lamellar vesicle structures: insights into vesicular body formation in endosomes. Biophys J (2009) 0.82
Characterization of the disordered-to-α-helical transition of IA₃ by SDSL-EPR spectroscopy. Protein Sci (2011) 0.81
The N-terminal domain of a TonB-dependent transporter undergoes a reversible stepwise denaturation. Biochemistry (2012) 0.81
A method for dynamic nuclear polarization enhancement of membrane proteins. Angew Chem Int Ed Engl (2014) 0.81
Ligand extraction properties of the GM2 activator protein and its interactions with lipid vesicles. Biophys J (2009) 0.81
Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach. Protein Sci (2009) 0.81
Closure of the cytoplasmic gate formed by TM5 and TM11 during transport in the oxalate/formate exchanger from Oxalobacter formigenes. Biochemistry (2014) 0.80
Molecular basis for substrate-dependent transmembrane signaling in an outer-membrane transporter. J Mol Biol (2007) 0.79
Interactions of the GM2 activator protein with phosphatidylcholine bilayers: a site-directed spin-labeling power saturation study. Biophys J (2009) 0.79
Intra and inter-molecular interactions dictate the aggregation state of irinotecan co-encapsulated with floxuridine inside liposomes. Pharm Res (2008) 0.79
Lipid and membrane mimetic environments modulate spin label side chain configuration in the outer membrane protein A. J Phys Chem B (2011) 0.78
Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. J Med Chem (2003) 0.78
Effects of the endosomal lipid bis(monoacylglycero)phosphate on the thermotropic properties of DPPC: A 2H NMR and spin label EPR study. Chem Phys Lipids (2010) 0.76
Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations. Biochem Biophys Res Commun (2010) 0.76
Spin-diffusion couples proton relaxation rates for proteins in exchange with a membrane interface. J Magn Reson (2008) 0.76
Enhanced archaeal laccase production in recombinant Escherichia coli by modification of N-terminal propeptide and twin arginine translocation motifs. J Ind Microbiol Biotechnol (2012) 0.75
Characterizing solution surface loop conformational flexibility of the GM2 activator protein. J Phys Chem B (2014) 0.75