Published in Age (Omaha) on October 01, 1997
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Catalase in vitro. Methods Enzymol (1984) 27.79
Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77
The aging process. Proc Natl Acad Sci U S A (1981) 4.66
Oxidative stress: the paradox of aerobic life. Biochem Soc Symp (1995) 2.91
Caloric restriction and aging. Sci Am (1996) 2.45
Free radical theory of aging. Mutat Res (1992) 2.05
Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal Biochem (1990) 1.76
A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res (1996) 1.76
Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. Mech Ageing Dev (1989) 1.40
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat liver. J Nutr (1990) 1.14
Length of life and nutrition in the rat. J Nutr (1961) 1.11
Relationship between antioxidants, prooxidants, and the aging process. Ann N Y Acad Sci (1992) 1.08
Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver. Biochim Biophys Acta (1991) 1.04
Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat. Mech Ageing Dev (1989) 0.98
Role of DNA repair enzymes in the cellular resistance to oxidative stress. Pathol Biol (Paris) (1996) 0.97
Role of caloric restriction in the prolongation of life. Clin Geriatr Med (1995) 0.96
Caloric restriction, aging, and antioxidant enzymes. Mutat Res (1993) 0.95
Catalases and peroxidases and glutathione and hydrogen peroxide: mysteries of the bestiary. J Lab Clin Med (1991) 0.95
Human erythrocyte glucose 6-phosphate dehydrogenase. Content of bound coenzyme. Biochem Biophys Res Commun (1974) 0.90
The role of free radicals in disease. Aust N Z J Ophthalmol (1995) 0.87
Role of protein oxidation in aging and in age-associated neurodegenerative diseases. Life Sci (1994) 0.86
Food restriction and the aging process. J Am Geriatr Soc (1984) 0.83
Free radicals in health and disease. Haematologia (Budap) (1995) 0.79
Regulation of glucose-6-phosphate dehydrogenase synthesis and mRNA abundance in cultured rat hepatocytes. Biochem J (1991) 0.79
Assay for mouse tissue enzymes: levels of activity and statistical variation for 29 enzymes of liver or brain. Anal Biochem (1980) 0.78
Ageing and free radicals. Med Lab Sci (1992) 0.78
Increased effective activity of rat liver catalase by dietary restriction. Age (Omaha) (1997) 0.78
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet (1994) 10.14
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics (2004) 7.15
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet (1997) 6.83
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (2001) 6.17
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci (1999) 5.24
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci U S A (2008) 4.45
Mechanisms and rates of decay of marine viruses in seawater. Appl Environ Microbiol (1992) 4.22
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
Good clinical outcomes following transjugular intrahepatic portosystemic stent-shunts in Budd-Chiari syndrome. Aliment Pharmacol Ther (2014) 3.39
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Comparison of Western immunoblots and gene detection assays for identification of potentially enterotoxigenic isolates of Clostridium perfringens. J Clin Microbiol (1994) 2.81
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan. Hum Mutat (1996) 2.80
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64
Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry (2000) 2.55
Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem (2001) 2.40
Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry. J Virol (1996) 2.36
Effects of humidification on nasal symptoms and compliance in sleep apnea patients using continuous positive airway pressure. Chest (1999) 2.26
The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem (2001) 2.25
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell (2001) 2.23
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Nodeless superconducting gap in A(x)Fe2Se2 (A=K,Cs) revealed by angle-resolved photoemission spectroscopy. Nat Mater (2011) 2.16
NFAT signaling in vertebrate development. Curr Opin Genet Dev (2001) 2.15
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc Natl Acad Sci U S A (1974) 2.14
Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene (1999) 2.14
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol (2015) 2.07
The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression. Genomics (1999) 2.04
Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis (2000) 2.04
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat Med (1999) 2.03
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: implications for chronic studies. Aging (Milano) (2001) 1.93
Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res (1995) 1.91
Distribution, isolation, host specificity, and diversity of cyanophages infecting marine Synechococcus spp. in river estuaries. Appl Environ Microbiol (2001) 1.90
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ (2001) 1.87
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem (1998) 1.83
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol (2000) 1.81
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem (1992) 1.79
Laparoscopic appendectomy significantly reduces length of stay for perforated appendicitis. Surg Endosc (2006) 1.79
Perforated rectal cancer associated with neoadjuvant radiotherapy: report of four cases. Dis Colon Rectum (2006) 1.77
Light scattering in the cornea. J Opt Soc Am (1969) 1.70
The G-rich auxiliary downstream element has distinct sequence and position requirements and mediates efficient 3' end pre-mRNA processing through a trans-acting factor. Nucleic Acids Res (1995) 1.70
Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. Toxicol Pathol (1996) 1.69
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity (1999) 1.66
Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals. Nucleic Acids Res (1994) 1.64
Mechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation. Cancer J Sci Am (2006) 1.64
Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J (2001) 1.64
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy. Mol Psychiatry (2004) 1.62
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer (2009) 1.60
Quantitative trait locus effects and environmental interaction in a sample of North American barley germ plasm. Theor Appl Genet (1993) 1.58
Effect of chronic caloric restriction on the synchronization of various physiological measures in old female Fischer 344 rats. Chronobiol Int (1990) 1.56
Karyotype instability in Cryptococcus neoformans infection. J Clin Microbiol (1996) 1.53
Is flow cytometry really adapted to the determination of sperm concentration? Scand J Clin Lab Invest (2007) 1.52
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins. J Virol (1994) 1.46
Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma. J Gen Virol (1991) 1.45
Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membrane protein LMP1. Oncogene (1993) 1.44
Ischemic sinus node hibernation: resolution following angioplasty. Am Heart J (1991) 1.43
Adrenergic responses in the human eye. J Pharmacol Exp Ther (1971) 1.43
Noninvasive localization of human atherosclerotic lesions with indium 111-labeled monoclonal Z2D3 antibody specific for proliferating smooth muscle cells. J Nucl Cardiol (1999) 1.43
Migration of cardiac neural crest cells in Splotch embryos. Development (2000) 1.43
Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect. Hum Genet (1995) 1.42
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Gamma imaging of atherosclerotic lesions: the role of antibody affinity in in vivo target localization. J Nucl Cardiol (1996) 1.41
Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. Mech Ageing Dev (1989) 1.40
Radiochemical purity of routinely prepared 99Tcm radiopharmaceuticals: a retrospective study. Nucl Med Commun (2000) 1.39
Target tissue specificity of retinoic acid-induced stress proteins and malformations in mice. Teratology (1991) 1.38
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. J Clin Invest (2000) 1.37
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res (1999) 1.36
The transparency of the mammalian cornea. J Physiol (1970) 1.36
Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc Natl Acad Sci U S A (1996) 1.35
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. Biochem J (2000) 1.31
The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J Immunol (1999) 1.30
Characterization of somatostatin receptors on human neuroblastoma tumors. Cell Growth Differ (1994) 1.30
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- and human herpesvirus type 8-carrying body cavity lymphoma line. J Gen Virol (1998) 1.28
The biosynthesis of monolignols: a "metabolic grid", or independent pathways to guaiacyl and syringyl units? Phytochemistry (2001) 1.28
Evidence that pyrimidine dimers in DNA can give rise to tumors. Proc Natl Acad Sci U S A (1977) 1.26
Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily. Biochem Biophys Res Commun (1998) 1.26