Published in Science on March 12, 1982
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Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med (1997) 4.26
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
Associations between smoking and body weight in the US population: analysis of NHANES II. Am J Public Health (1987) 3.44
Dietary restriction in Drosophila: delayed aging or experimental artefact? PLoS Genet (2007) 2.51
Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci U S A (2001) 2.28
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun (2014) 1.96
Caloric restriction and aging: studies in mice and monkeys. Toxicol Pathol (2008) 1.93
Effects of age and caloric restriction on glutathione redox state in mice. Free Radic Biol Med (2003) 1.86
Calorie restriction and prevention of age-associated chronic disease. FEBS Lett (2011) 1.69
Dietary restriction and aging: a unifying perspective. Cell Metab (2011) 1.67
Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem (2009) 1.60
Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. Aging Cell (2008) 1.52
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci (2010) 1.51
Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev (2011) 1.47
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J Leukoc Biol (2008) 1.40
The diet restriction paradigm: a brief review of the effects of every-other-day feeding. Age (Dordr) (2005) 1.40
Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev (2010) 1.39
Effects of food restriction on aging: separation of food intake and adiposity. Proc Natl Acad Sci U S A (1984) 1.31
Pro-oxidant shift in glutathione redox state during aging. Adv Drug Deliv Rev (2008) 1.30
SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med (2013) 1.30
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α. Neurobiol Dis (2012) 1.26
Nonhuman primate models of human immunology. Antioxid Redox Signal (2010) 1.26
Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice. Clin Diagn Lab Immunol (2001) 1.23
Energy intake and leukocyte telomere length in young adults. Am J Clin Nutr (2012) 1.18
NRF2, cancer and calorie restriction. Oncogene (2010) 1.17
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma. Neuro Oncol (2005) 1.16
Hormonal regulation of longevity in mammals. Ageing Res Rev (2007) 1.15
Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice. Proc Natl Acad Sci U S A (1984) 1.12
Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies. Mech Ageing Dev (2008) 1.10
Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Exp Gerontol (2008) 1.10
Metabolic regulation of stem cell behavior and implications for aging. Cell Metab (2010) 1.10
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09
Age-related loss of spiral ganglion neurons. Hear Res (2009) 1.07
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging (Albany NY) (2009) 1.05
Calorie restriction and susceptibility to intact pathogens. Age (Dordr) (2008) 1.05
The role of nutrition in enhancing immunity in aging. Aging Dis (2011) 0.99
Trade-offs between cancer and other diseases: do they exist and influence longevity? Rejuvenation Res (2010) 0.98
Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions? Age (Dordr) (2009) 0.95
Calorie restriction and stroke. Exp Transl Stroke Med (2011) 0.95
Calorie restriction: what recent results suggest for the future of ageing research. Eur J Clin Invest (2010) 0.95
Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell (2009) 0.95
Caloric restriction: implications for human cardiometabolic health. J Cardiopulm Rehabil Prev (2013) 0.93
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Curr Opin Clin Nutr Metab Care (2009) 0.93
Calories versus protein in onset of renal disease in NZB x NZW mice. Proc Natl Acad Sci U S A (1986) 0.93
Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet? Oxid Med Cell Longev (2013) 0.93
NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction. J Clin Exp Pathol (2012) 0.92
Mitochondrial acetylation and diseases of aging. J Aging Res (2011) 0.91
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle (2012) 0.91
Having it all: historical energy intakes do not generate the anticipated trade-offs in fecundity. Proc Biol Sci (2006) 0.91
RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans. Brief Funct Genomics (2010) 0.91
Caloric restriction improves health and survival of rhesus monkeys. Nat Commun (2017) 0.90
Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr) (2009) 0.89
Calorie restriction in mammals and simple model organisms. Biomed Res Int (2014) 0.89
The somatotropic axis and longevity in mice. Am J Physiol Endocrinol Metab (2015) 0.87
Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics. Theor Biol Med Model (2010) 0.87
Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS One (2013) 0.87
Decrease by chronic energy intake restriction of cellular proliferation in the intestinal epithelium and lymphoid organs in autoimmunity-prone mice. Proc Natl Acad Sci U S A (1989) 0.87
Fasting levels of hepatic p-S6 are increased in old mice. Cell Cycle (2014) 0.86
Impaired iron status in aging research. Int J Mol Sci (2012) 0.86
Dietary restriction with and without caloric restriction for healthy aging. F1000Res (2016) 0.85
The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse. Oncotarget (2015) 0.85
The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse. Oncotarget (2015) 0.84
Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics (2014) 0.84
Honoring Clive McCay and 75 years of calorie restriction research. J Nutr (2010) 0.83
Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice. Am J Pathol (1984) 0.83
Cardioprotective Signature of Short-Term Caloric Restriction. PLoS One (2015) 0.82
The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice. Age (Dordr) (2013) 0.82
Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Exp Gerontol (2011) 0.81
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer (2015) 0.81
Combination of physical activity, nutrition, or other metabolic factors and vaccine response. Front Biosci (2007) 0.80
Unraveling the message: insights into comparative genomics of the naked mole-rat. Mamm Genome (2016) 0.80
Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells". Int J Stem Cells (2008) 0.80
Calorie restriction extends life span--but which calories? PLoS Med (2005) 0.80
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice. Longev Healthspan (2012) 0.79
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Comparative endocrinology of aging and longevity regulation. Front Endocrinol (Lausanne) (2011) 0.79
Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients (2016) 0.79
Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Front Neuroendocrinol (2012) 0.79
Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics (2013) 0.79
Bayesian Analysis of the Effect of Intentional Weight Loss on Mortality Rate. Int J Body Compos Res (2008) 0.78
Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta (2012) 0.78
Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility. Curr Transl Geriatr Exp Gerontol Rep (2013) 0.78
Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice. Korean J Physiol Pharmacol (2015) 0.76
Effects of adult onset mild calorie restriction on weight of reproductive organs, plasma parameters and gene expression in male mice. Anim Reprod (2012) 0.76
Cancer: When restriction is good. Nature (2009) 0.76
A computational approach to studying ageing at the individual level. Proc Biol Sci (2016) 0.76
Deletion of ghrelin prevents aging-associated obesity and muscle dysfunction without affecting longevity. Aging Cell (2017) 0.75
The effect of developmental nutrition on life span and fecundity depends on the adult reproductive environment in Drosophila melanogaster. Ecol Evol (2015) 0.75
Clinical Experience of a Diet Designed to Reduce Aging. J Appl Res (2009) 0.75
You don't need a weatherman: famines, evolution, and intervention into aging. Age (Dordr) (2006) 0.75
Fitness consequences of altered feeding behavior in immune-challenged mosquitoes. Parasit Vectors (2016) 0.75
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol (1998) 2.18
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids. J Natl Cancer Inst (1973) 1.79
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol. Mutat Res (1989) 1.68
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
Influence of the main histocompatibility complex on ageing in mice. Nature (1978) 1.63
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Increased incidence of lymphoma after injections of mice with cells differing at weak histocompatibility loci. Science (1966) 1.56
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Acute childhood leukaemia in relation to the HL-A human transplantation genes. Nature (1970) 1.51
Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr (2000) 1.50
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev (1997) 1.47
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Influence of controlled dietary restriction on immunologic function and aging. Fed Proc (1979) 1.39
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res (1999) 1.36
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
Life span and lymphoma-incidence of mice injected at birth with spleen cells across a weak histocompatibility locus. Am J Pathol (1965) 1.32
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
The HL-A system sub-loci and their importance in transplantation. Transplant Proc (1969) 1.27
Histocompatibility systems and disease states with particular reference to cancer. Transplant Rev (1971) 1.27
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Longterm dietary restriction and immune function in mice: response to sheep red blood cells and to mitogenic agents. Mech Ageing Dev (1974) 1.23
Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr (1992) 1.21
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol (1997) 1.19
Using a closed ecological system to study Earth's biosphere: initial results from Biosphere 2. Bioscience (1993) 1.18
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice. J Gerontol (1988) 1.16
Human T lymphocytes possess a limited in vitro life span. Exp Gerontol (1989) 1.15
Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain. J Immunol (1973) 1.15
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst (1999) 1.14
HL-A antigens in myasthenia gravis. Lancet (1974) 1.14
Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys (1996) 1.14
Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am J Physiol (1999) 1.12
Studies in immunogerontology. J Am Geriatr Soc (1982) 1.12
Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech Ageing Dev (2001) 1.12
Age-related decline in thymic-independent immune function in a long-lived mouse strain. J Gerontol (1974) 1.12
The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity. Cell Immunol (1983) 1.12
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev (1997) 1.09
Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically. J Biol Chem (1996) 1.07
Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol (1980) 1.07
Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr (1987) 1.06
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
The distribution of HL-A histocompatibility factors and genes in patients with systemic lupus erythematosus. Tissue Antigens (1971) 1.05
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Autoimmunity in relation to aging as measured by agar plaque technique. Proc Soc Exp Biol Med (1966) 1.03
Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens (1978) 1.03
Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Arch Intern Med (1998) 1.03
The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice. J Gerontol (1983) 1.02
Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice. Fed Proc (1975) 1.02
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
Diminished T-cell response to influenza virus in aged mice. Immunology (1983) 1.01
Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A (1982) 1.00
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Immunologic theory of aging: current status. Fed Proc (1974) 0.99
Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia (1975) 0.99
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Concerns about rodent models for aging research. J Gerontol (1991) 0.96
Caloric restriction, aging, and antioxidant enzymes. Mutat Res (1993) 0.95
Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice. J Nutr (1997) 0.94
Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med (1999) 0.94
Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice. Cancer Res (1994) 0.93
Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA. J Nutr (1990) 0.92
In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res (1993) 0.92
Autoimmunity and aging: the age-related response of mice of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells. J Immunol (1976) 0.92
Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res (1991) 0.92
The prevalence of dysequilibrium and related disorders in older persons. Ear Nose Throat J (1989) 0.92
Synergy among responding lymphoid cells in the one-way mixed lymphocyte reaction. Interaction between two types of thymus-dependent cells. J Exp Med (1974) 0.91
Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Antioxid Redox Signal (1999) 0.91
Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. J Gerontol A Biol Sci Med Sci (1998) 0.91
Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol (1998) 0.91
Antisera for tissue-typing: the production of cytotoxic and agglutinating antibodies following intradermal leukocyte injections in man. Blood (1968) 0.90
The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech Ageing Dev (1993) 0.90
Reduced immune responses in rhesus monkeys subjected to dietary restriction. J Gerontol A Biol Sci Med Sci (1996) 0.90