Published in Cancer Res on April 01, 1999
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) (2008) 2.14
Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci (2009) 2.02
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics (2007) 1.94
Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 1.82
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci U S A (2006) 1.40
Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell (2014) 1.29
NRF2, cancer and calorie restriction. Oncogene (2010) 1.17
Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. Nutr J (2011) 1.14
Will calorie restriction work in humans? Aging (Albany NY) (2013) 1.11
Systematic Literature Review of Risk Factors and Treatments for Ulcerative Dermatitis in C57BL/6 Mice. Comp Med (2015) 1.06
Mechanisms of aging in senescence-accelerated mice. Genome Biol (2005) 1.02
Epigenetic regulation of caloric restriction in aging. BMC Med (2011) 0.99
Calorie restriction and late-onset calorie restriction extend lifespan but do not alter protein storage in female grasshoppers. Mech Ageing Dev (2006) 0.93
Lifelong caloric restriction increases working memory in mice. PLoS One (2013) 0.92
Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice. Exp Neurol (2011) 0.90
Caloric restriction and heart function: is there a sensible link? Acta Pharmacol Sin (2010) 0.88
Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. Age (Dordr) (2011) 0.88
Role of uncoupling proteins in cancer. Cancers (Basel) (2010) 0.86
Dietary epigenetics in cancer and aging. Cancer Treat Res (2014) 0.85
The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. J Gerontol A Biol Sci Med Sci (2014) 0.82
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mamm Genome (2016) 0.78
Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta (2012) 0.78
The Impact of External Factors on the Epigenome: In Utero and over Lifetime. Biomed Res Int (2016) 0.77
Hypoxia and dehydroepiandrosterone in old age: a mouse survival study. Respir Res (2006) 0.77
Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome. Age (Dordr) (2012) 0.77
Potential Site Effects and Transgene Expression Discrepancies in Mouse Lifespan Studies. Cell Metab (2015) 0.76
You don't need a weatherman: famines, evolution, and intervention into aging. Age (Dordr) (2006) 0.75
Morphologic assessment of oxidative damage: A review. J Am Aging Assoc (2000) 0.75
Calorie restriction in rodents: Caveats to consider. Ageing Res Rev (2017) 0.75
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab (2017) 0.75
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
Cell culture of human colon adenomas and carcinomas. Cancer Res (1987) 2.68
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest (1996) 2.07
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
Characteristics of streptolysin O action. Infect Immun (1971) 1.97
Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer (2000) 1.85
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res (2001) 1.48
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene (1995) 1.46
Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun (1990) 1.44
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient. Leukemia (1991) 1.41
The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res (2000) 1.41
Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog (1992) 1.38
Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ (1996) 1.38
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility. Free Radic Biol Med (2001) 1.36
Localization of fibronectin within the renal glomerulus and its production by cultured glomerular cells. Am J Pathol (1979) 1.35
Characterization of human uroepithelial cells immortalized in vitro by simian virus 40. Cancer Res (1987) 1.34
Cell division in normal and transformed cells: the possible role of superoxide and hydrogen peroxide. Med Hypotheses (1981) 1.34
Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1. J Biol Chem (1999) 1.33
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. Arch Biochem Biophys (1999) 1.32
Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Cancer Res (2001) 1.30
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Aging reduces adaptive capacity and stress protein expression in the liver after heat stress. J Appl Physiol (1985) (2000) 1.27
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Res (2001) 1.26
Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene (1997) 1.25
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr (1992) 1.21
Stem cell characteristics of transplanted rat mammary clonogens. Exp Cell Res (2000) 1.20
Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch Biochem Biophys (1987) 1.20
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol (1997) 1.19
Cell differentiation, aging and cancer: the possible roles of superoxide and superoxide dismutases. Med Hypotheses (1980) 1.19
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol (1996) 1.17
Role of antioxidant enzymes in cell immortalization and transformation. Mol Cell Biochem (1988) 1.15
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst (1999) 1.14
Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res (1999) 1.14
Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys (1996) 1.14
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. Cancer Res (2000) 1.13
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res (1999) 1.11
Immune adherence in renal glomeruli. Complement receptor sites on glomerular capillary epithelial cells. Am J Pathol (1977) 1.11
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
Growth kinetics and differentiation in vitro of normal human uroepithelial cells on collagen gel substrates in defined medium. J Cell Physiol (1987) 1.10
Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells. Hum Gene Ther (1997) 1.09
Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype. Prostate (1998) 1.08
Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J Biol Chem (1998) 1.07
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice. Int J Cancer (2001) 1.07
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr (1987) 1.06
Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation. Cancer Res (1995) 1.05
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. FASEB J (1999) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines. Arch Biochem Biophys (1990) 1.04
Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res (1994) 1.04
Antitumor effect of a copper coordination compound with superoxide dismutase-like activity. J Natl Cancer Inst (1981) 1.03
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs. Am J Kidney Dis (1992) 1.02
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
Detection of autoantibodies and glomerular injury in rabbits immunized with denatured human fibronectin monomer. Am J Pathol (1984) 1.01
Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A (1982) 1.00
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Expression of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med (1994) 1.00
In vitro growth and differentiation of human kidney tubular cells on a basement membrane substrate. In Vitro Cell Dev Biol (1987) 0.99
Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury. Free Radic Biol Med (2000) 0.98
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle. J Cell Physiol (1998) 0.96
Cytochemical characterization of cultured adult, guinea pig glomerular cells. Invest Cell Pathol (1980) 0.96
Concerns about rodent models for aging research. J Gerontol (1991) 0.96
Caloric restriction, aging, and antioxidant enzymes. Mutat Res (1993) 0.95
Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: mechanistic studies. J Cell Physiol (1998) 0.95
Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med (1999) 0.94
The role of superoxide dismutase and gene amplification in carcinogenesis. J Theor Biol (1984) 0.94
Culture of human glomerular cells. Am J Pathol (1979) 0.94
Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy. Cancer Res (1995) 0.94
Splanchnic tissues undergo hypoxic stress during whole body hyperthermia. Am J Physiol (1999) 0.93