Evolutionary cell biology of chromosome segregation: insights from trypanosomes.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3866873)

Published in Open Biol on May 01, 2013

Authors

Bungo Akiyoshi1, Keith Gull

Author Affiliations

1: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

Articles citing this

Discovery of unconventional kinetochores in kinetoplastids. Cell (2014) 1.70

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects. Elife (2014) 1.03

Catch and release: how do kinetochores hook the right microtubules during mitosis? Trends Genet (2014) 0.90

Anarchic centromeres: deciphering order from apparent chaos. Curr Opin Cell Biol (2013) 0.87

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes. J Cell Biol (2016) 0.82

The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole). Cell Microbiol (2013) 0.82

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance. Nat Commun (2016) 0.79

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. Mol Biol Cell (2014) 0.79

Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus? Trends Cell Biol (2016) 0.79

Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and Leishmania mexicana flagella. Methods Cell Biol (2015) 0.77

Divergent polo box domains underpin the unique kinetoplastid kinetochore. Open Biol (2016) 0.77

New insights into the molecular mechanisms of mitosis and cytokinesis in trypanosomes. Int Rev Cell Mol Biol (2014) 0.77

How nontraditional model systems can save us. Mol Biol Cell (2015) 0.77

The spindle assembly checkpoint promotes chromosome bi-orientation: A novel Mad1 role in chromosome alignment. Cell Cycle (2016) 0.76

The unconventional kinetoplastid kinetochore: from discovery toward functional understanding. Biochem Soc Trans (2016) 0.75

Diversity and Divergence of Dinoflagellate Histone Proteins. G3 (Bethesda) (2015) 0.75

Touching from a distance. Nucleus (2014) 0.75

Comparative analysis of chromosome segregation in human, yeasts and trypanosome. Front Biol (Beijing) (2014) 0.75

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase. PLoS Pathog (2017) 0.75

Articles cited by this

(truncated to the top 100)

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

Universal control mechanism regulating onset of M-phase. Nature (1990) 19.11

The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33

Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93

Genetic control of the cell division cycle in yeast. Science (1974) 13.83

HMMER web server: interactive sequence similarity searching. Nucleic Acids Res (2011) 13.00

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell (1997) 12.90

Feedback control of mitosis in budding yeast. Cell (1991) 12.39

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol (1999) 11.77

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell (1991) 11.56

The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48

Beyond self-assembly: from microtubules to morphogenesis. Cell (1986) 10.53

Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell (1983) 9.90

A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell (1997) 9.79

The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66

Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature (1980) 9.38

The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64

Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication. Acta Trop (1979) 8.43

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell (1995) 8.34

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61

The centromere paradox: stable inheritance with rapidly evolving DNA. Science (2001) 7.50

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature (1999) 7.21

How cells get the right chromosomes. Science (1997) 6.88

Budding yeast Cdc20: a target of the spindle checkpoint. Science (1998) 6.59

Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J Cell Sci (1989) 6.48

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell (1995) 6.23

Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma (1985) 6.17

Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis (2009) 5.96

Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37

Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc Natl Acad Sci U S A (1998) 5.28

Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study. J Cell Biol (1991) 5.16

Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem (2000) 4.96

Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet (2007) 4.58

Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature (2003) 4.33

Genetic definition and sequence analysis of Arabidopsis centromeres. Science (1999) 4.20

Life without transcriptional control? From fly to man and back again. EMBO J (2002) 4.14

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome Res (2011) 4.09

The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa. Int J Syst Evol Microbiol (2002) 3.84

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol (2005) 3.77

Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J Cell Biol (1995) 3.73

Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev (2009) 3.62

Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature (2005) 3.54

The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci U S A (1997) 3.53

Phylogenomics of the nucleosome. Nat Struct Biol (2003) 3.52

The revised classification of eukaryotes. J Eukaryot Microbiol (2012) 3.48

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24

Antigenic variation in trypanosomes. Nature (1978) 3.24

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol (2011) 3.17

Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei. J Cell Sci (1990) 3.16

Elements of error correction in mitosis: microtubule capture, release, and tension. J Cell Biol (1994) 3.06

Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol (2006) 2.99

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99

DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96

Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle. Nature (1991) 2.93

Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. Nature (1990) 2.91

Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle. J Cell Biol (1995) 2.85

The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations. Philos Trans R Soc Lond B Biol Sci (1989) 2.81

A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei. Mol Biochem Parasitol (1996) 2.75

The fine structure of the kinetochore of a mammalian cell in vitro. Chromosoma (1966) 2.68

Pushing and pulling in prokaryotic DNA segregation. Cell (2010) 2.59

A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature (2001) 2.59

High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature (2012) 2.55

Major evolutionary transitions in centromere complexity. Cell (2009) 2.49

Force production by disassembling microtubules. Nature (2005) 2.47

Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres. Science (2008) 2.45

Rooting the eukaryote tree by using a derived gene fusion. Science (2002) 2.42

Inducible gene expression in trypanosomes mediated by a prokaryotic repressor. Science (1995) 2.42

Highly efficient tandem affinity purification of trypanosome protein complexes based on a novel epitope combination. Eukaryot Cell (2005) 2.39

Estimating and mapping the population at risk of sleeping sickness. PLoS Negl Trop Dis (2012) 2.31

Kinetochores moving away from their associated pole do not exert a significant pushing force on the chromosome. J Cell Biol (1996) 2.21

Bacterial chromosome organization and segregation. Cold Spring Harb Perspect Biol (2010) 2.11

A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol Biol Cell (2003) 2.09

Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis. J Cell Sci (1999) 2.07

Homologous recombination and stable transfection in the parasitic protozoan Trypanosoma brucei. Science (1990) 2.06

The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends Biochem Sci (1998) 1.99

Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin. J Biol Chem (2003) 1.99

Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96

Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science (2012) 1.94

Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique. Proc Natl Acad Sci U S A (2004) 1.85

The cell biology of Trypanosoma brucei differentiation. Curr Opin Microbiol (2007) 1.84

Polymorphism and mitochondrial activity in sleeping sickness trypanosomes. Nature (1965) 1.80

Flies without a spindle checkpoint. Nat Cell Biol (2007) 1.80

The evolution and diversity of kinetoplastid flagellates. Trends Parasitol (2006) 1.79

Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic tree. Biol Lett (2009) 1.78

Visualization of detyrosination along single microtubules reveals novel mechanisms of assembly during cytoskeletal duplication in trypanosomes. Cell (1989) 1.77

High frequency of antigenic variation in Trypanosoma brucei rhodesiense infections. Parasitology (1989) 1.76

The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion. J Biol Chem (2004) 1.75

Golgi duplication in Trypanosoma brucei. J Cell Biol (2004) 1.75

Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor. Mol Cell Proteomics (2009) 1.74

Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes Dev (2004) 1.72

Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell (2010) 1.70

Early-branching or fast-evolving eukaryotes? An answer based on slowly evolving positions. Proc Biol Sci (2000) 1.69

Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS Pathog (2010) 1.69

Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol (2011) 1.69

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Curr Opin Microbiol (2010) 1.64

Chromosome replication and segregation in bacteria. Annu Rev Genet (2012) 1.63

Origins of DNA replication in the three domains of life. FEBS J (2005) 1.63

Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act. Nat Rev Microbiol (2012) 1.61

Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci (2010) 1.58

Articles by these authors

The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61

Flagellar motility is required for the viability of the bloodstream trypanosome. Nature (2006) 4.71

The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet (2006) 3.06

Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei. Mol Biochem Parasitol (2002) 2.74

Centriole/basal body morphogenesis and migration during ciliogenesis in animal cells. J Cell Sci (2007) 2.46

A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol Biol Cell (2003) 2.09

Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96

Reconstructing the evolutionary history of the centriole from protein components. J Cell Sci (2010) 1.87

Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography. J Cell Sci (2009) 1.82

Dyneins across eukaryotes: a comparative genomic analysis. Traffic (2007) 1.81

Molecular evolution of FtsZ protein sequences encoded within the genomes of archaea, bacteria, and eukaryota. J Mol Evol (2004) 1.65

A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functions. Mol Biol Cell (2006) 1.59

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. Proc Natl Acad Sci U S A (2005) 1.58

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci (2009) 1.58

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly. Trends Parasitol (2009) 1.54

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell (2006) 1.47

A repetitive protein essential for the flagellum attachment zone filament structure and function in Trypanosoma brucei. Protist (2007) 1.44

Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist (2007) 1.43

The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction. J Cell Sci (2004) 1.43

More than one way to build a flagellum: comparative genomics of parasitic protozoa. Curr Biol (2004) 1.36

The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism. Nucleic Acids Res (2003) 1.33

Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation. J Cell Sci (2006) 1.29

Cell biology of the trypanosome genome. Microbiol Mol Biol Rev (2010) 1.27

An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. Traffic (2007) 1.27

The paraflagellar rod of kinetoplastid parasites: from structure to components and function. Int J Parasitol (2009) 1.25

The evolution of the cytoskeleton. J Cell Biol (2011) 1.22

The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis. J Cell Sci (2005) 1.21

The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology. Mol Microbiol (2010) 1.21

The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes. Genome Res (2004) 1.20

Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum. J Biol Chem (2008) 1.19

Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton. BMC Evol Biol (2010) 1.17

Gamma-tubulin functions in the nucleation of a discrete subset of microtubules in the eukaryotic flagellum. Curr Biol (2003) 1.17

Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei. J Cell Sci (2010) 1.14

The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis. Mol Cell Biol (2010) 1.14

A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet (2011) 1.12

The hydrocephalus inducing gene product, Hydin, positions axonemal central pair microtubules. BMC Biol (2007) 1.11

Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes. J Cell Sci (2006) 1.11

Diversification of function by different isoforms of conventionally shared RNA polymerase subunits. Mol Biol Cell (2007) 1.11

Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites. J Mol Evol (2005) 1.10

Repetitive elements in genomes of parasitic protozoa. Microbiol Mol Biol Rev (2003) 1.09

Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes. Proc Natl Acad Sci U S A (2009) 1.08

Integration of pZJM library plasmids into unexpected locations in the Trypanosoma brucei genome. Mol Biochem Parasitol (2004) 1.08

Cytokinesis in Trypanosoma brucei differs between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis. Mol Microbiol (2013) 1.04

Flagellar and ciliary beating in trypanosome motility. Cell Motil Cytoskeleton (2007) 1.04

Beyond 9+0: noncanonical axoneme structures characterize sensory cilia from protists to humans. FASEB J (2010) 1.04

Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum. Mol Biol Cell (2004) 1.03

Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei. Cell Rep (2012) 1.01

The trypanosome flagellum. J Cell Sci (2003) 1.01

The limits on trypanosomatid morphological diversity. PLoS One (2013) 0.98

Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast. Mol Microbiol (2007) 0.98

A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei. PLoS One (2012) 0.98

A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryot Cell (2013) 0.97

The structural mechanics of cell division in Trypanosoma brucei. Biochem Soc Trans (2008) 0.97

An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei. Mol Cell Biol (2005) 0.97

Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei. PLoS Pathog (2012) 0.97

Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma brucei. J Struct Biol (2012) 0.96

Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC Genomics (2006) 0.96

The frequency of gene targeting in Trypanosoma brucei is independent of target site copy number. Nucleic Acids Res (2003) 0.96

Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoa. Eukaryot Cell (2005) 0.95

Perturbation of phosphatidylethanolamine synthesis affects mitochondrial morphology and cell-cycle progression in procyclic-form Trypanosoma brucei. Mol Microbiol (2009) 0.95

Cell morphogenesis of Trypanosoma brucei requires the paralogous, differentially expressed calpain-related proteins CAP5.5 and CAP5.5V. Protist (2009) 0.94

A protein-protein interaction map of the Trypanosoma brucei paraflagellar rod. PLoS One (2009) 0.94

Detailed interrogation of trypanosome cell biology via differential organelle staining and automated image analysis. BMC Biol (2012) 0.94

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection. Eukaryot Cell (2007) 0.94

The evolution of land plant cilia. New Phytol (2012) 0.94

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One (2009) 0.94

Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei. J Biol Chem (2005) 0.94

Conservation of ciliary proteins in plants with no cilia. BMC Plant Biol (2011) 0.91

A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology. Mol Microbiol (2008) 0.91

WCB is a C2 domain protein defining the plasma membrane - sub-pellicular microtubule corset of kinetoplastid parasites. Protist (2007) 0.90

Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages. Mol Microbiol (2008) 0.90

Relationships between the major kinetoplastid paraflagellar rod proteins: a consolidating nomenclature. Mol Biochem Parasitol (2004) 0.90

Calmodulin is required for paraflagellar rod assembly and flagellum-cell body attachment in trypanosomes. Protist (2013) 0.90

The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. PLoS One (2010) 0.89

A cell-body groove housing the new flagellum tip suggests an adaptation of cellular morphogenesis for parasitism in the bloodstream form of Trypanosoma brucei. J Cell Sci (2013) 0.88

Analysis of the trypanosome flagellar proteome using a combined electron transfer/collisionally activated dissociation strategy. J Am Soc Mass Spectrom (2008) 0.88

Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei. Elife (2014) 0.88

Cytokinesis in trypanosomes. Cytoskeleton (Hoboken) (2012) 0.87

Ultrastructural investigation methods for Trypanosoma brucei. Methods Cell Biol (2010) 0.87

Bioinformatic insights to the ESAG5 and GRESAG5 gene families in kinetoplastid parasites. Mol Biochem Parasitol (2008) 0.87

A post-assembly structural modification to the lumen of flagellar microtubule doublets. Curr Biol (2006) 0.86

Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea. Biol Direct (2009) 0.86

Functional studies of an evolutionarily conserved, cytochrome b5 domain protein reveal a specific role in axonemal organisation and the general phenomenon of post-division axonemal growth in trypanosomes. Cell Motil Cytoskeleton (2009) 0.86

Ab initio identification of novel regulatory elements in the genome of Trypanosoma brucei by Bayesian inference on sequence segmentation. PLoS One (2011) 0.85

Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations. Mol Microbiol (2008) 0.85

Depletion of mitochondrial acyl carrier protein in bloodstream-form Trypanosoma brucei causes a kinetoplast segregation defect. Eukaryot Cell (2011) 0.85

Evidence for a sliding-resistance at the tip of the trypanosome flagellum. Cell Motil Cytoskeleton (2006) 0.84

Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1. Mol Microbiol (2013) 0.84

A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains. Protist (2011) 0.84

Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC Genomics (2006) 0.83

The mitotic stability of the minichromosomes of Trypanosoma brucei. Mol Biochem Parasitol (2003) 0.83

The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function. Eukaryot Cell (2012) 0.79

Proteomics and the Trypanosoma brucei cytoskeleton: advances and opportunities. Parasitology (2012) 0.79

An expanded family of proteins with BPI/LBP/PLUNC-like domains in trypanosome parasites: an association with pathogenicity? Biochem Soc Trans (2011) 0.77