Published in J Cell Biol on August 01, 1967
Flagellar elongation and shortening in Chlamydomonas. The use of cycloheximide and colchicine to study the synthesis and assembly of flagellar proteins. J Cell Biol (1969) 8.72
The role of three cytoplasmic fibers in BHK-21 cell motility. I. Microtubules and the effects of colchicine. J Cell Biol (1971) 6.96
The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol (1967) 6.85
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. J Cell Biol (1968) 4.65
The association of a class of saltatory movements with microtubules in cultured cells. J Cell Biol (1970) 4.50
Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1970) 4.20
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. J Clin Invest (1974) 3.65
Cytochalasin B: effect on lysosomal enzyme release from human leukocytes. Proc Natl Acad Sci U S A (1973) 3.63
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol (2011) 3.53
Are cytoplasmic microtubules heteropolymers? Proc Natl Acad Sci U S A (1971) 3.38
Precipitation of proteins by vinblastine and calcium ions. Proc Natl Acad Sci U S A (1970) 3.00
Cilia regeneration in Tetrahymena and its inhibition by colchicine. J Cell Biol (1969) 2.97
Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures. J Cell Biol (1975) 2.94
Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella. J Cell Biol (1968) 2.91
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning. Proc Natl Acad Sci U S A (1977) 2.72
Fibrous proteins--neuronal organelles. Proc Natl Acad Sci U S A (1968) 2.66
Microtubule protein. Identification in and transport to nerve endings. J Cell Biol (1971) 2.58
Effect of colchicine and vinblastine on the topographical separation of membrane functions. J Exp Med (1972) 2.57
Colchicine inhibition of plasma protein release from rat hepatocytes. J Cell Biol (1975) 2.56
On the role of microtubules in movement and alignment of nuclei in virus-induced syncytia. J Cell Biol (1968) 2.53
Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans. J Cell Biol (1977) 2.41
Mechanism of the indirect sympathomimetic effect of 5-hydroxytrypt-amine on the isolated heart of the rabbit. Br J Pharmacol (1976) 2.38
The role of microtubules in the movement of pigment granules in teleost melanophores. J Cell Biol (1974) 2.21
Isolation and partial characterization of alpha and beta-tubulin from outer doublets of sea-urchin sperm and microtubules of chick-embryo brain. Proc Natl Acad Sci U S A (1973) 2.14
Force and length in the mitotic spindle. Curr Biol (2009) 2.11
Dissolution of erythrocyte membranes in water and comparison of the membrane protein with other structural proteins. Proc Natl Acad Sci U S A (1968) 1.99
Histamine release from human leukocytes: studies with deuterium oxide, colchicine, and cytochalasin B. J Clin Invest (1972) 1.98
Synthesis and storage of microtubule proteins by sea urchin embryos. J Cell Biol (1971) 1.95
The effects of parathyroid hormone, colchicine, and calcitonin on the ultrastructure and the activity of osteoclasts in organ culture. J Cell Biol (1974) 1.94
Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. J Cell Biol (1972) 1.89
Microtubules and sensory transduction. Proc Natl Acad Sci U S A (1971) 1.87
The organization of synaptic axcplasm in the lamprey (petromyzon marinus) central nervous system. J Cell Biol (1970) 1.83
Factors affecting the redistribution of surface-bound concanavalin A on human polymorphonuclear leukocytes. J Cell Biol (1974) 1.78
Heterogeneity of tubulin subunits. Proc Natl Acad Sci U S A (1971) 1.77
Stable polymers of the axonal cytoskeleton: the axoplasmic ghost. J Cell Biol (1982) 1.74
Drugs that target dynamic microtubules: a new molecular perspective. Med Res Rev (2011) 1.70
The mechanism of action of colchicine. Colchicine binding properties of sea urchin sperm tail outer doublet tubulin. J Cell Biol (1973) 1.68
Effects of colchicine and vinca alkaloids on human platelets. 3. Influence on primary internal contraction and secondary aggregation. Am J Pathol (1969) 1.63
Changes in the organization of tubulin during meiosis in the eggs of the surf clam, Spisula solidissima. J Cell Biol (1972) 1.62
Characterization of the colchicine binding of membrane fractions from rat and mouse liver. J Cell Biol (1974) 1.62
Muscle-like contractile proteins and tubulin in synaptosomes. Proc Natl Acad Sci U S A (1974) 1.60
Some properties of the protein forming the outer fibers of cilia. J Cell Biol (1968) 1.53
Effects of colchicine and Vinca alkaloids on human platelets. I. Influence on platelet microtubules and contractile function. Am J Pathol (1968) 1.53
Axoplasmic transport in the crayfish nerve cord. The role of fibrillar constituents of neurons. J Cell Biol (1971) 1.49
Effects of colchicine on cyclic AMP levels in human leukocytes. Proc Natl Acad Sci U S A (1977) 1.47
Fine structural changes in neurons and nerve fibers associated with colchicine inhibition of nerve fiber formation in vitro. J Cell Biol (1973) 1.45
Segregation during ascidian embryogenesis of egg cytoplasmic information for tissue-specific enzyme development. Proc Natl Acad Sci U S A (1973) 1.45
Identification of direct protein targets of small molecules. ACS Chem Biol (2010) 1.44
The movement of optically detectable organelles in myelinated axons of Xenopus laevis. J Physiol (1974) 1.43
Colchicine-binding protein and the secretion of thyroid hormone. J Cell Biol (1972) 1.40
Colchicine binding in tissue slices. Decrease by calcium and biphasic effect of adenosine-3', 5'-monophosphate. J Cell Biol (1971) 1.39
Chemical modulation of diphtheria toxin action on cultured mammalian cells. Infect Immun (1975) 1.37
In vitro aggregation of cytoplasmic microtubule subunits. Proc Natl Acad Sci U S A (1972) 1.36
Cilia in cell-cultured fibroblasts. II. Incidence in mitotic and post-mitotic BHK 21-C13 fibroblasts. J Anat (1971) 1.36
A quantitative ultrastructural study of microtubule content and secretory granule accumulation in parathyroid glands of phosphate- and colchicine-treated rats. J Clin Invest (1975) 1.35
Effect of nerve growth factor on the expression of colchicine-binding activity and 14-3-2 protein in an established line of human neuroblastoma. Proc Natl Acad Sci U S A (1974) 1.35
Experimental manipulation of the amount of tubulin available for assembly into the spindle of dividing sea urchin eggs. J Cell Biol (1976) 1.29
Promotion of fluorescence upon binding of colchicine to tubulin. Proc Natl Acad Sci U S A (1974) 1.27
Interactions of microtubule disorganizers, plant hormones, and red light in wheat coleoptile segment growth. Plant Physiol (1975) 1.26
Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction. J Cell Biol (1976) 1.25
Colchicine inhibits adrenal medullary secretion evoked by acetylcholine without affecting that evoked by potassium. Br J Pharmacol (1972) 1.25
Effects of colchicine and vinca alkaloids on human platelets. II. Changes in the dense tubular system and formation of an unusual inclusion in incubated cells. Am J Pathol (1968) 1.24
Microtubule biogenesis and cell shape in Ochromonas. II. The role of nucleating sites in shape development. J Cell Biol (1973) 1.21
Condensing vacuole conversion and zymogen granule discharge in pancreatic exocrine cells: metabolic studies. J Cell Biol (1971) 1.19
Virus replication, cytopathology, and lysosomal enzyme response of mitotic and interphase Hep-2 cells infected with poliovirus. J Virol (1973) 1.19
The melanocyte model. Colchicine-like effects of other antimitotic agents. J Cell Biol (1971) 1.17
The effect of colchicine on myogenesis in vivo in Rana pipiens and Rhodnius prolixus (Hemiptera). J Cell Biol (1968) 1.11
Targeting microtubules by natural agents for cancer therapy. Mol Cancer Ther (2014) 1.08
Synthesis of a colchicine-binding protein during the HeLa cell life cycle. J Cell Biol (1969) 1.07
Developmental anomalies in farm animals: I. Theoretical considerations. Can Vet J (1988) 1.06
Further evidence for the involvement of microtubules in the intra-axonal movement of noradrenaline storage granules. J Physiol (1971) 1.03
Endocrine secretory mechanisms. A review. Am J Pathol (1975) 1.03
Microtubule protein synthesis during oogenesis and early embryogenesis in Xenopus laevis. Biochem J (1975) 1.01
Velocity distributions of the streaming protoplasm in Nitella flexilis. Biophys J (1977) 1.00
Mitotic force generators and chromosome segregation. Cell Mol Life Sci (2010) 0.98
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism. J Cell Biol (2015) 0.98
Cell elongation in the cultured embryonic chick lens epithelium with and without protein synthesis. Involvement of microtubules. J Cell Biol (1972) 0.97
Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress. Mediators Inflamm (2014) 0.96
Tachyphylaxis to ethacrynic acid in the isolated atrium of guinea-pig and its relation to noradrenaline stores. Br J Pharmacol (1978) 0.96
Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien Klin Wochenschr (2004) 0.95
Selective extraction of isolated mitotic apparatus. Evidence that typical microtubule protein is extracted by organic mercurial. J Cell Biol (1971) 0.95
Evolutionary cell biology of chromosome segregation: insights from trypanosomes. Open Biol (2013) 0.95
Phosphorylation of myosin light chain during capping of mouse T-lymphoma cells. J Cell Biol (1981) 0.95
Colchicine-binding protein of the liver. Its characterization and relation to microtubules. J Cell Biol (1975) 0.94
Molecules in mammalian brain that interact with the colchicine site on tubulin. Proc Natl Acad Sci U S A (1979) 0.94
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. J Med Chem (2011) 0.94
Action of vinblastine on the spontaneous release of acetylcholine at the frog neuromuscular junction. J Physiol (1976) 0.93
Effects of colchicine and vinblastine on the cellular action of vasopressin in mammalian kidney. A possible role of microtubules. J Clin Invest (1974) 0.93
Ca2+- and calmodulin-stimulated endogenous phosphorylation of neurotubulin. Proc Natl Acad Sci U S A (1981) 0.92
Association of microfilament bundles with lysosomes in polymorphonuclear leukocytes. J Cell Biol (1976) 0.92
Fate of secretory proteins trapped in oocytes of Xenopus laevis by disruption of the cytoskeleton or by imbalanced subunit synthesis. J Cell Biol (1981) 0.91
Reactive neuroaxonal dystrophy in children. Clinical pathological correlation. Acta Neuropathol (1978) 0.91
Microtubule protein during ciliogenesis in the mouse oviduct. J Cell Biol (1974) 0.90
Effect of mitosis inhibitors on blood platelet microtubules and aggregation. J Physiol (1971) 0.89
ε-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies. J Cell Sci (2013) 0.88
The effects of varying concentrations of colchicine on the progression of grasshopper neuroblasts into metaphase. J Cell Biol (1971) 0.87
Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins. Proc Natl Acad Sci U S A (1979) 0.87
The mechanism of rosette formation between Rh (D)-positive erythrocytes and peripheral blood lymphocytes from Rh isoimmunized individuals. The role of surface micro-projections. Immunology (1972) 0.86
Metabolic and ionic requirements for the axoplasmic transport of dopamine beta-hydroxylase. J Physiol (1974) 0.85
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Estimation of the molecular weights of proteins by Sephadex gel-filtration. Biochem J (1964) 35.63
On flagellar structure in certain flagellates. J Biophys Biochem Cytol (1960) 19.37
THE ULTRASTRUCTURE OF A MAMMALIAN CELL DURING THE MITOTIC CYCLE. J Cell Biol (1964) 9.18
The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol (1967) 6.85
STUDIES ON THE PROTEIN COMPONENTS OF CILIA FROM TETRAHYMENA PYRIFORMIS. Proc Natl Acad Sci U S A (1963) 6.67
Electron microscopic studies of mitosis in amebae. II. The giant ameba Pelomyxa carolinensis. J Cell Biol (1962) 5.25
HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO THE INTERPHASE CELL. J Histochem Cytochem (1964) 5.22
Chemical dissection of cilia. Arch Biol (Liege) (1965) 5.11
THE MECHANISM OF COLCHICINE INHIBITION OF MITOSIS. I. KINETICS OF INHIBITION AND THE BINDING OF H3-COLCHICINE. J Cell Biol (1965) 4.48
Cytoplasmic microfilaments in streaming Nitella cells. J Ultrastruct Res (1966) 4.42
Isolated cilia from Tetrahymena pyriformis. Exp Cell Res (1962) 3.29
Mechanism for Plant Cellular Morphogenesis. Science (1962) 3.12
Microtubules in the microspikes and cortical cytoplasm of isolated cells. J Cell Biol (1966) 2.97
An electron microscope study of myofibril formation in embryonic chick skeletal muscle. J Cell Biol (1967) 2.90
RELATION OF PROTEIN SYNTHESIS TO THE DIVISION CYCLE IN MAMMALIAN CELL CULTURES. J Cell Biol (1963) 2.27
The effect of colchicine on striated muscle in tissue culture. Exp Cell Res (1955) 2.11
Colchicine. I. General pharmacology. J Pharmacol Exp Ther (1952) 1.53
A study of actin by means of starch gel electrophoresis. Biochemistry (1963) 1.52
The colchicine-binding protein of mammalian brain and its relation to microtubules. Biochemistry (1968) 12.96
Mechanism of adenosine triphosphate hydrolysis by actomyosin. Biochemistry (1971) 9.73
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol (1999) 8.24
A structural change in the kinesin motor protein that drives motility. Nature (1999) 6.92
The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol (1967) 6.85
Microtubules. Annu Rev Biochem (1973) 6.75
Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J Cell Biol (1997) 6.67
Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro. Proc Natl Acad Sci U S A (1975) 6.35
Nucleated assembly of microtubules in porcine brain extracts. Science (1972) 6.22
Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly. J Cell Biol (1980) 5.64
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Ann N Y Acad Sci (1975) 5.26
Structural polarity and directional growth of microtubules of Chlamydomonas flagella. J Mol Biol (1974) 4.80
Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. J Cell Biol (1987) 4.52
The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation. J Cell Biol (1977) 4.41
Functional coordination of microtubule-based and actin-based motility in melanophores. Curr Biol (1998) 4.03
Energetics and mechanism of actomyosin adenosine triphosphatase. Biochemistry (1976) 3.97
Self-polarization and directional motility of cytoplasm. Curr Biol (1999) 3.93
Kinetochore microtubule dynamics and the metaphase-anaphase transition. J Cell Biol (1995) 3.86
Mechanism of actomyosin ATPase and the problem of muscle contraction. CRC Crit Rev Biochem (1979) 3.83
Microtubule assembly in vitro. Fed Proc (1974) 3.82
Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles. J Cell Biol (1995) 3.55
Direct observation of microtubule dynamics in living cells. Nature (1988) 3.47
Cytoplasmic filaments and tubules. Fed Proc (1968) 3.22
Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy. J Cell Biol (1981) 3.17
Kinetic analysis of microtubule self-assembly in vitro. J Mol Biol (1977) 3.15
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High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry. Proc Natl Acad Sci U S A (2000) 2.96
Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella. J Cell Biol (1968) 2.91
Isolated flagellar apparatus of Chlamydomonas: characterization of forward swimming and alteration of waveform and reversal of motion by calcium ions in vitro. J Cell Sci (1978) 2.91
Phosphoproteins are components of mitotic microtubule organizing centers. Proc Natl Acad Sci U S A (1984) 2.84
Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro. J Cell Biol (1980) 2.75
Kinetic studies of the cooperative binding of subfragment 1 to regulated actin. Proc Natl Acad Sci U S A (1980) 2.74
Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes. J Cell Biol (1985) 2.72
Characterization of microtubule assembly in porcine brain extracts by viscometry. Biochemistry (1973) 2.68
On the mechanisms of cytokinesis in animal cells. J Theor Biol (1983) 2.63
Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol (1998) 2.59
Interacting head mechanism of microtubule-kinesin ATPase. J Biol Chem (1997) 2.57
Microtubule dynamics in vivo: a test of mechanisms of turnover. J Cell Biol (1987) 2.56
Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J Cell Biol (1990) 2.46
Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate muscles. J Mol Biol (1980) 2.46
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The non-tubulin component of microtubule protein oligomers. Effect on self-association and hydrodynamic properties. J Biol Chem (1978) 2.36
Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism. Biochemistry (1978) 2.35
Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J Cell Biol (1996) 2.35
Microtubule dynamics and chromosome motion visualized in living anaphase cells. J Cell Biol (1988) 2.31
Microtuble assembly: some possible regulatory mechanisms. J Supramol Struct (1974) 2.21
Differential turnover of tyrosinated and detyrosinated microtubules. Proc Natl Acad Sci U S A (1987) 2.15
Transient state phosphate production in the hydrolysis of nucleoside triphosphates by myosin. Biochemistry (1970) 2.11
Non-sarcomeric mode of myosin II organization in the fibroblast lamellum. J Cell Biol (1993) 2.10
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Identity and polymerization-stimulatory activity of the nontubulin proteins associated with microtubules. Biochemistry (1977) 2.07
Proposed definitions for the audit of postoperative infection: a discussion paper. Surgical Infection Study Group. Ann R Coll Surg Engl (1991) 2.06
Microtubule treadmilling in vivo. Science (1997) 2.05
Polarity of microtubules of the mitotic spindle. J Mol Biol (1978) 2.02
Self-assembly of microtubules in extracts of cultured HeLa cells and the identification of HeLa microtubule-associated proteins. Proc Natl Acad Sci U S A (1979) 1.99
Further purification and characterization of slime mold myosin and slime mold actin. Biochemistry (1969) 1.96
Management of abdominal aortic aneurysm. Br J Surg (1978) 1.95
Improved procedures for electron microscopic visualization of the cytoskeleton of cultured cells. J Struct Biol (1996) 1.93
Survey of operating theatres in Great Britain and Ireland. J Hosp Infect (1995) 1.92
Early return to work after repair of a unilateral inguinal hernia. Br J Surg (1983) 1.89
Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. J Cell Biol (1972) 1.89
Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis. J Cell Biol (1996) 1.88
Origin of kinetochore microtubules in Chinese hamster ovary cells. Chromosoma (1980) 1.87
Immunofluorescence localization of HeLa cell microtubule-associated proteins on microtubules in vitro and in vivo. J Cell Biol (1980) 1.87
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Microtubules are acetylated in domains that turn over slowly. J Cell Sci (1989) 1.86
Growth and lability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin. J Cell Biol (1974) 1.85
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Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates. J Cell Biol (1980) 1.74
The ATPase mechanism of skeletal and smooth muscle acto-subfragment 1. J Biol Chem (1984) 1.71
A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. Anal Biochem (1972) 1.70
Removal of the projections from cytoplasmic microtubules in vitro by digestion with trypsin. J Biol Chem (1977) 1.65
Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase. J Cell Biol (1989) 1.64
Structure of kinetochore fibers: microtubule continuity and inter-microtubule bridges. Chromosoma (1981) 1.64
Centrosomal and non-centrosomal microtubules. Biol Cell (1999) 1.64
The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells. Recovery from low temperature treatment. Chromosoma (1981) 1.64
Two components of actin-based retrograde flow in sea urchin coelomocytes. Mol Biol Cell (1999) 1.63
Studies on the kinetics of formation and dissociation of the actomyosin complex. Biochemistry (1969) 1.60
Speckle microscopic evaluation of microtubule transport in growing nerve processes. Nat Cell Biol (1999) 1.60
Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1. Biochemistry (1977) 1.60
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Steady state dynamics of intermediate filament networks. J Cell Biol (1992) 1.59
Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis. J Cell Sci (1991) 1.58
Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition. J Cell Sci (1994) 1.57
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Mechanism of microtubule kinesin ATPase. Biochemistry (1995) 1.55
Assembly and turnover of detyrosinated tubulin in vivo. J Cell Biol (1987) 1.55