Published in Mol Cell on January 01, 2002
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol (2008) 4.08
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J (2002) 3.42
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell (2009) 3.36
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat Rev Mol Cell Biol (2013) 3.01
Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol (2006) 2.99
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol (2003) 2.21
Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell (2013) 2.06
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell (2014) 2.03
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J (2006) 1.89
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol (2003) 1.83
Mad2 and Mad3 cooperate to arrest budding yeast in mitosis. Curr Biol (2011) 1.79
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells. Curr Biol (2012) 1.78
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Proc Natl Acad Sci U S A (2007) 1.74
Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension. Mol Biol Cell (2002) 1.72
Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model. J Cell Biol (2006) 1.70
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. J Cell Sci (2011) 1.68
Mad2 phosphorylation regulates its association with Mad1 and the APC/C. EMBO J (2003) 1.68
Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev (2014) 1.65
The spindle assembly checkpoint works like a rheostat rather than a toggle switch. Nat Cell Biol (2013) 1.65
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes. J Cell Biol (2004) 1.60
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev (2008) 1.59
Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p. Mol Cell Biol (2004) 1.54
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol Biol Cell (2005) 1.49
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell (2012) 1.47
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem (2010) 1.40
The influence of catalysis on mad2 activation dynamics. PLoS Biol (2009) 1.40
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol (2011) 1.35
In vivo dynamics of Drosophila nuclear envelope components. Mol Biol Cell (2008) 1.30
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Dev Cell (2014) 1.28
Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics (2005) 1.26
Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.24
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint. EMBO J (2011) 1.19
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet). Mol Biol Cell (2011) 1.15
The composition, functions, and regulation of the budding yeast kinetochore. Genetics (2013) 1.15
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation. J Cell Biol (2012) 1.14
Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation. Nat Struct Mol Biol (2015) 1.12
Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans. Genetics (2006) 1.12
A brief history of error. Nat Cell Biol (2011) 1.12
Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. J Cell Biol (2006) 1.11
Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol (2008) 1.11
Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat Struct Mol Biol (2013) 1.09
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest. J Cell Biol (2003) 1.08
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. Elife (2015) 1.07
Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis. Nucleic Acids Res (2007) 1.06
Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO J (2011) 1.06
The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis (2009) 1.05
Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint. Chromosoma (2012) 1.05
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition. Proc Natl Acad Sci U S A (2010) 1.04
Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression. J Biol Chem (2011) 1.04
Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2. Philos Trans R Soc Lond B Biol Sci (2005) 1.04
A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment. EMBO Rep (2014) 1.00
Modeling dual pathways for the metazoan spindle assembly checkpoint. Proc Natl Acad Sci U S A (2006) 0.99
Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation. EMBO J (2014) 0.98
Mad2 inhibits the mitotic kinesin MKlp2. J Cell Biol (2010) 0.97
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching. J Cell Biol (2008) 0.97
The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem (2014) 0.96
Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature (2016) 0.96
TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. J Cell Biol (2015) 0.96
The current view for the silencing of the spindle assembly checkpoint. Cell Cycle (2014) 0.95
Evolutionary cell biology of chromosome segregation: insights from trypanosomes. Open Biol (2013) 0.95
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores. J Virol (2010) 0.94
Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity. J Biol Chem (2014) 0.94
Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1. Mol Biol Cell (2012) 0.93
Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans. EMBO J (2008) 0.92
Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer. Exp Mol Pathol (2009) 0.90
Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster. Mol Cell Biol (2010) 0.90
Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. J Biol Chem (2013) 0.90
MTBP plays a crucial role in mitotic progression and chromosome segregation. Cell Death Differ (2011) 0.89
Depletion of p31comet protein promotes sensitivity to antimitotic drugs. J Biol Chem (2012) 0.89
Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle (2011) 0.88
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS Genet (2014) 0.88
Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Nat Cell Biol (2015) 0.87
A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol (2014) 0.87
Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint. Chromosoma (2015) 0.87
Basis of catalytic assembly of the mitotic checkpoint complex. Nature (2017) 0.86
How oocytes try to get it right: spindle checkpoint control in meiosis. Chromosoma (2015) 0.84
Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells. Cell Cycle (2013) 0.84
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex. Proc Natl Acad Sci U S A (2016) 0.83
A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint. Biochem J (2006) 0.82
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling. Elife (2017) 0.82
Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Structure (2015) 0.82
Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A (2015) 0.82
Spatial-temporal model for silencing of the mitotic spindle assembly checkpoint. Nat Commun (2014) 0.81
RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. J Biol Chem (2012) 0.81
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol Cell (2006) 3.38
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol (2007) 3.15
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science (2012) 2.70
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol (2005) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J (2006) 2.13
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J (2005) 1.91
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J (2003) 1.89
Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem (2003) 1.89
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J (2005) 1.86
A protein sequence that can encode native structure by disfavoring alternate conformations. Nat Struct Biol (2002) 1.85
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr Biol (2013) 1.69
A minimal domain responsible for Munc13 activity. Nat Struct Mol Biol (2005) 1.68
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Biochemistry (2008) 1.67
Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci (2013) 1.66
At the junction of SNARE and SM protein function. Curr Opin Cell Biol (2010) 1.65
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol (2010) 1.63
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A (2004) 1.63
Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem (2004) 1.63
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle. Biochemistry (2010) 1.46
Adsorption of ionizable organic contaminants on multi-walled carbon nanotubes with different oxygen contents. J Hazard Mater (2010) 1.45
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc (2009) 1.38
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc Natl Acad Sci U S A (2002) 1.37
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. Proc Natl Acad Sci U S A (2009) 1.37
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem (2003) 1.35
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem (2006) 1.34
Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci (2010) 1.34
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci (2002) 1.32
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure (2011) 1.32
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay. Methods Mol Biol (2004) 1.30
Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc (2010) 1.30
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem (2005) 1.29
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
Selective detection of mercury (II) ion using nonlinear optical properties of gold nanoparticles. J Am Chem Soc (2008) 1.29
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proc Natl Acad Sci U S A (2008) 1.29
Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list. Mutat Res (2004) 1.28
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nat Struct Mol Biol (2004) 1.26
Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy. Biochemistry (2003) 1.25
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells. Nat Neurosci (2002) 1.25
The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. J Biol Chem (2002) 1.25
Remote homology between Munc13 MUN domain and vesicle tethering complexes. J Mol Biol (2009) 1.24
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23
A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling. J Am Chem Soc (2013) 1.23
Toxicity and environmental risks of nanomaterials: challenges and future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2009) 1.22