Chloride binding site of neurotransmitter sodium symporters.

X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature (2013) 3.00

X-ray structures and mechanism of the human serotonin transporter. Nature (2016) 1.21

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J Physiol (2013) 1.06

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. J Clin Invest (2014) 0.92

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus. ACS Chem Neurosci (2015) 0.91

Microseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuT. J Biol Chem (2014) 0.88

The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem (2013) 0.88

Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT. Proc Natl Acad Sci U S A (2013) 0.88

Computational characterization of structural dynamics underlying function in active membrane transporters. Curr Opin Struct Biol (2015) 0.87

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. J Biol Chem (2015) 0.87

Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding. Front Neurol (2015) 0.86

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. J Biol Chem (2014) 0.84

Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog. J Biol Chem (2015) 0.84

Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter. Structure (2015) 0.84

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun (2016) 0.83

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins (2015) 0.83

Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophys J (2014) 0.82

Biophysical Approaches to the Study of LeuT, a Prokaryotic Homolog of Neurotransmitter Sodium Symporters. Methods Enzymol (2015) 0.80

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. J Biol Chem (2016) 0.80

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter. J Biol Chem (2016) 0.79

Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics. PLoS One (2016) 0.78

Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochim Biophys Acta (2015) 0.77

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR. Elife (2017) 0.75

Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes. Curr Opin Struct Biol (2016) 0.75

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49

MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56

The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science (2008) 4.94

A competitive inhibitor traps LeuT in an open-to-out conformation. Science (2008) 4.86

Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci (2003) 4.50

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature (2007) 4.29

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (2007) 4.08

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch (2003) 3.76

Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (2008) 3.39

Structure and mechanism of a Na+-independent amino acid transporter. Science (2009) 3.30

Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP. Nature (2009) 3.27

Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci U S A (2008) 3.24

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature (2012) 3.24

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature (2010) 2.41

Structure and mechanism of an amino acid antiporter. Science (2009) 2.40

Identification of a chloride ion binding site in Na+/Cl -dependent transporters. Proc Natl Acad Sci U S A (2007) 2.32

Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol (2008) 2.27

Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc Natl Acad Sci U S A (2007) 2.27

Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature (2007) 2.25

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol (2009) 2.12

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J Biol Chem (2005) 2.03

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01

Neurotransmitter transporters: molecular function of important drug targets. Trends Pharmacol Sci (2006) 2.01

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature (2010) 1.85

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A (1992) 1.79

Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem (2003) 1.70

Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. J Biol Chem (2003) 1.60

Experimental conditions can obscure the second high-affinity site in LeuT. Nat Struct Mol Biol (2012) 1.37

Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT. Biophys J (2008) 1.34

Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT. Biophys J (2012) 1.30

Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophys J (2010) 1.27

Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. J Neurosci (2009) 1.23

The role of local hydration and hydrogen-bonding dynamics in ion and solute release from ion-coupled secondary transporters. Biochemistry (2011) 1.20

Molecular mechanism of substrate specificity in the bacterial neutral amino acid transporter LeuT. Proteins (2008) 1.11

The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology (2010) 1.11

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. J Biol Chem (2012) 1.09

Substrate specificity and ion coupling in the Na+/betaine symporter BetP. EMBO J (2011) 1.07

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep (2012) 1.05

Substrate-dependent proton antiport in neurotransmitter:sodium symporters. Nat Chem Biol (2009) 1.04

LeuT: a prokaryotic stepping stone on the way to a eukaryotic neurotransmitter transporter structure. Channels (Austin) (2011) 1.03

Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Mol Pharmacol (1999) 0.98

Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue. J Biol Chem (2010) 0.93

The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. J Synchrotron Radiat (2010) 0.91

A glutamine residue conserved in the neurotransmitter:sodium:symporters is essential for the interaction of chloride with the GABA transporter GAT-1. J Biol Chem (2010) 0.91

Role of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1. Cell Mol Life Sci (2006) 0.90

A homology model of SERT based on the LeuT(Aa) template. Bioorg Med Chem Lett (2006) 0.89

Effects of serine mutations in transmembrane domain 7 of the human norepinephrine transporter on substrate binding and transport. J Neurochem (1999) 0.84

The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function. J Auton Pharmacol (1999) 0.77

Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

Crystal structure of the sodium-potassium pump. Nature (2007) 5.12

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol (2003) 3.77

The structural basis of calcium transport by the calcium pump. Nature (2007) 3.35

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01

Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol (2009) 2.98

SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem (2002) 2.87

Cyanine fluorophore derivatives with enhanced photostability. Nat Methods (2011) 2.85

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem (2002) 2.75

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

Phosphoryl transfer and calcium ion occlusion in the calcium pump. Science (2004) 2.69

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A (2009) 2.69

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60

PDZBase: a protein-protein interaction database for PDZ-domains. Bioinformatics (2004) 2.55

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation (2012) 2.55

Crystal structure of a copper-transporting PIB-type ATPase. Nature (2011) 2.51

Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation. EMBO J (2007) 2.48

Crystal structure of the plasma membrane proton pump. Nature (2007) 2.41

Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature (2010) 2.41

Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33

Quantitative information management for the biochemical computation of cellular networks. Sci STKE (2004) 2.32

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30

P-type ATPases. Annu Rev Biophys (2011) 2.29

Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep (2004) 2.28

D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Mol Pharmacol (2007) 2.28

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM. Nat Struct Mol Biol (2004) 2.27

Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc Natl Acad Sci U S A (2007) 2.27

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu Rev Pharmacol Toxicol (2002) 2.27

Twin-spot MARCM to reveal the developmental origin and identity of neurons. Nat Neurosci (2009) 2.26

Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature (2007) 2.25

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice. Proc Natl Acad Sci U S A (2004) 2.10

Local resistance switching at grain and grain boundary surfaces of polycrystalline tungsten oxide films. Nanotechnology (2011) 2.09

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer Prev Res (Phila) (2008) 2.04

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron (2006) 2.00

Dephosphorylation of the calcium pump coupled to counterion occlusion. Science (2004) 2.00

Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A (2005) 1.98

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol (2004) 1.94

Additional support for a revised Gibbs analysis. Langmuir (2010) 1.94

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol (2005) 1.89

Modulatory and catalytic modes of ATP binding by the calcium pump. EMBO J (2006) 1.89

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem (2012) 1.87

Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proc Natl Acad Sci U S A (2009) 1.79

The sarcoplasmic Ca2+-ATPase: design of a perfect chemi-osmotic pump. Q Rev Biophys (2010) 1.78

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry (2009) 1.71

Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem (2003) 1.70

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat Struct Biol (2003) 1.69

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 1.69

Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. J Biol Chem (2003) 1.69

Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell (2013) 1.67