Published in J Biol Chem on April 05, 2011
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Retracted GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis. J Cell Sci (2012) 2.05
Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep (2014) 1.42
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur J Cancer Prev (2016) 1.39
Role of transcription factor acetylation in diabetic kidney disease. Diabetes (2014) 1.20
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab (2013) 1.14
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem (2012) 1.08
Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood (2012) 1.05
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab (2013) 1.01
Regulation and function of signal transducer and activator of transcription 3. World J Biol Chem (2014) 1.01
Critical analysis of the potential for targeting STAT3 in human malignancy. Onco Targets Ther (2013) 0.99
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Toward a new STATe: the role of STATs in mitochondrial function. Semin Immunol (2014) 0.95
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A (2013) 0.92
Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. J Biol Chem (2013) 0.87
STAT transcription in the ischemic heart. JAKSTAT (2012) 0.87
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. Sci Rep (2015) 0.86
STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance. Front Oncol (2015) 0.86
SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth. Int J Clin Exp Med (2014) 0.86
Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress. JAKSTAT (2012) 0.85
Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab (2015) 0.83
Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods Mol Biol (2013) 0.82
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal (2014) 0.82
Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart. JAKSTAT (2013) 0.82
SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis (2013) 0.81
STAT3 Activities and Energy Metabolism: Dangerous Liaisons. Cancers (Basel) (2014) 0.81
Stat3: friend or foe in colitis and colitis-associated cancer? Inflamm Bowel Dis (2014) 0.80
SDF-1/CXCL12 modulates mitochondrial respiration of immature blood cells in a bi-phasic manner. Blood Cells Mol Dis (2016) 0.76
Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma. Oncol Lett (2017) 0.75
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nat Commun (2016) 0.75
15∝-methoxypuupehenol induces antitumor effects in vitro and in vivo against human glioblastoma and breast cancer models. Mol Cancer Ther (2017) 0.75
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. Sci Rep (2017) 0.75
Conserved and species-specific molecular denominators in mammalian skeletal muscle aging. NPJ Aging Mech Dis (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol (1963) 29.15
Nuclear factor-kappaB in cancer development and progression. Nature (2006) 18.31
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Notch signalling regulates stem cell numbers in vitro and in vivo. Nature (2006) 5.49
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science (2005) 5.31
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
Function of mitochondrial Stat3 in cellular respiration. Science (2009) 5.13
Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta (1994) 4.93
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
Serine phosphorylation of STATs. Oncogene (2000) 4.21
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A (2007) 4.05
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A (2006) 3.97
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science (2009) 3.89
Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des (2009) 3.20
Tracking STAT nuclear traffic. Nat Rev Immunol (2006) 2.99
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans (2003) 2.81
A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Am J Hum Genet (2005) 2.73
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol (2000) 2.70
STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol (2009) 2.67
Sirtuins in aging and disease. Cold Spring Harb Symp Quant Biol (2007) 2.66
Retracted Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. J Cell Sci (2010) 2.56
Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev (2009) 2.35
GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J (2003) 2.00
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol (2010) 1.94
Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol (2010) 1.88
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A (2003) 1.80
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem (2005) 1.77
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev (2009) 1.69
SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68
Mitochondrial sirtuins. Biochim Biophys Acta (2010) 1.67
STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. Gastroenterology (2005) 1.56
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. Blood (2003) 1.53
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest (2010) 1.50
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. J Cell Biol (2009) 1.47
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp Cell Res (2002) 1.44
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
Stoichiometry of STAT3 and mitochondrial proteins: Implications for the regulation of oxidative phosphorylation by protein-protein interactions. J Biol Chem (2010) 1.28
Lactate as a marker of energy failure in critically ill patients: hypothesis. Crit Care (2005) 1.24
S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. Endocrinology (2008) 1.23
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A (2005) 1.22
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays (2008) 1.17
Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. Breast Cancer Res (2010) 1.17
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution. Nucleic Acids Res (2008) 1.12
Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia (2008) 1.12
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Exp Hematol (2003) 1.10
Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol (2003) 1.08
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J Biol Chem (2001) 1.07
Measuring mitochondrial bioenergetics in INS-1E insulinoma cells. Methods Enzymol (2009) 1.06
AsSIRTing the DNA damage response. Trends Cell Biol (2008) 1.05
Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. J Biol Chem (2001) 1.04
Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3. J Biol Chem (2003) 1.02
STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma. Int J Cancer (2006) 0.98
HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. Biochem Biophys Res Commun (2009) 0.96
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway. Endocrinology (1997) 0.96
Physical and functional interactions between STAT3 and ZIP kinase. Int Immunol (2005) 0.95
Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform. J Biol Chem (1996) 0.95
Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes. Mol Cell Biol (2006) 0.95
Cell biology. Moonlighting in mitochondria. Science (2009) 0.94
Variations in spare electron transport chain capacity: The answer to an old riddle? J Neurosci Res (2003) 0.93
Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts. Exp Mol Med (2009) 0.91
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle. Mech Ageing Dev (2010) 0.85
Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis. Brain Res Bull (2009) 0.85
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci U S A (2002) 11.11
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res (2005) 11.02
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther (2008) 8.83
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Oncogenic mutations of ALK kinase in neuroblastoma. Nature (2008) 5.80
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A (2009) 3.58
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.95
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem (2002) 2.91
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Med (2006) 2.78
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci (2007) 2.68
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates. Mol Ther (2005) 2.48
Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer (2012) 2.48
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype. Blood (2003) 2.21
The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol (2007) 2.17
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity (2007) 2.11
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Experimental demonstration of topological surface states protected by time-reversal symmetry. Phys Rev Lett (2009) 1.99
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab (2011) 1.98
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell (2006) 1.93
Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93
Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci (2004) 1.92
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci (2003) 1.88
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. Am J Respir Crit Care Med (2009) 1.81
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78