Published in Nature on June 27, 2007
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Retracted Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature (2014) 6.57
Derivation of novel human ground state naive pluripotent stem cells. Nature (2013) 5.90
Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell (2008) 5.47
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Capturing pluripotency. Cell (2008) 5.08
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res (2010) 4.67
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature (2009) 3.70
The cell-cycle state of stem cells determines cell fate propensity. Cell (2013) 3.50
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells. Nature (2009) 3.43
Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Res (2009) 3.36
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
The transcriptional foundation of pluripotency. Development (2009) 3.21
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 3.12
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A (2010) 3.01
The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell (2008) 2.94
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol (2009) 2.86
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development (2009) 2.83
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature (2012) 2.80
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell (2011) 2.79
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell (2009) 2.72
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell (2010) 2.69
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell (2014) 2.68
A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell (2010) 2.65
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell (2014) 2.60
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature (2015) 2.47
Generation of chimeric rhesus monkeys. Cell (2012) 2.41
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Extrinsic regulation of pluripotent stem cells. Nature (2010) 2.39
Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol (2011) 2.32
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31
Pluripotent stem cell lines. Genes Dev (2008) 2.25
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J (2012) 2.24
Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev (2011) 2.22
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21
Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells (2008) 2.20
Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLoS One (2009) 2.18
Isolation of epiblast stem cells from preimplantation mouse embryos. Cell Stem Cell (2011) 2.16
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11
Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 2.09
Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell (2009) 2.09
Derivation of naive human embryonic stem cells. Proc Natl Acad Sci U S A (2014) 2.04
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol (2012) 2.00
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc Natl Acad Sci U S A (2011) 1.97
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol (2012) 1.94
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci U S A (2012) 1.93
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
An alternative pluripotent state confers interspecies chimaeric competency. Nature (2015) 1.90
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol (2010) 1.86
Making the blastocyst: lessons from the mouse. J Clin Invest (2010) 1.85
Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells. Nat Methods (2011) 1.85
Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species. Genome Res (2010) 1.81
Blimp1 expression predicts embryonic stem cell development in vitro. Curr Biol (2011) 1.76
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol (2014) 1.76
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis. Dev Cell (2015) 1.75
Epigenetics of reprogramming to induced pluripotency. Cell (2013) 1.73
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers. Philos Trans R Soc Lond B Biol Sci (2013) 1.70
Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch Toxicol (2011) 1.69
Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development (2009) 1.66
The biology of activin: recent advances in structure, regulation and function. J Endocrinol (2009) 1.64
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.63
Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev (2010) 1.62
FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J (2011) 1.61
Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo. PLoS One (2009) 1.61
Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One (2010) 1.60
Hallmarks of pluripotency. Nature (2015) 1.60
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development (2010) 1.58
Histone variant macroH2A confers resistance to nuclear reprogramming. EMBO J (2011) 1.57
p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer (2011) 1.54
Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell (2012) 1.54
Albumin-associated lipids regulate human embryonic stem cell self-renewal. PLoS One (2008) 1.54
Dynamics of gene silencing during X inactivation using allele-specific RNA-seq. Genome Biol (2015) 1.53
Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol (2010) 1.52
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development (2010) 1.51
Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature (2012) 1.51
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci (2005) 4.86
Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91
Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet (2005) 3.73
The cell-cycle state of stem cells determines cell fate propensity. Cell (2013) 3.50
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet (2004) 3.38
Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology (2010) 3.16
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development (2009) 2.83
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell (2011) 2.79
A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells. Hum Reprod (2003) 2.66
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev Biol (2004) 2.57
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol (2007) 2.46
Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev (2011) 2.22
Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Stem Cells (2007) 2.20
Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLoS One (2009) 2.18
Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell (2007) 2.14
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development (2010) 2.05
Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells (2009) 1.96
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol (2012) 1.94
Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells. Stem Cells (2005) 1.82
Generation of stella-GFP transgenic mice: a novel tool to study germ cell development. Genesis (2006) 1.72
Epigenetic status of human embryonic stem cells. Nat Genet (2005) 1.64
Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One (2010) 1.60
Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines. Hum Mol Genet (2007) 1.55
Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell (2012) 1.54
Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells (2011) 1.51
Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be? Reproduction (2014) 1.49
Human pre-implantation embryo development. Development (2012) 1.44
Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc (2013) 1.44
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell (2013) 1.39
Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell types. Stem Cells Dev (2010) 1.34
Stem cell medicine encounters the immune system. Nat Rev Immunol (2002) 1.34
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res (2007) 1.33
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nat Cell Biol (2010) 1.25
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. Biochem Soc Trans (2008) 1.23
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell (2010) 1.21
New directions in craniofacial morphogenesis. Dev Biol (2009) 1.19
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome. Diabetes (2003) 1.18
HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells. Stem Cells (2006) 1.14
Emerging use of stem cells in regenerative medicine. Biochem J (2010) 1.14
Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells. Blood (2006) 1.12
Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells. Stem Cells (2007) 1.12
Injection of embryonic stem cells into scarred rabbit vocal folds enhances healing and improves viscoelasticity: short-term results. Laryngoscope (2007) 1.09
Enhancing and diminishing gene function in human embryonic stem cells. Stem Cells (2004) 1.07
Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines. Cell Res (2007) 1.07
Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports (2013) 1.05
Dynamics of gene expression during bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro. Biochim Biophys Acta (2008) 1.05
Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro. Stem Cells Dev (2007) 1.05
Molecular architecture of the DNA replication origin activation checkpoint. EMBO J (2010) 1.04
Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency. Curr Protoc Stem Cell Biol (2007) 1.04
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development (2012) 1.04
Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development (2013) 1.04
Real-time PCR mapping of DNaseI-hypersensitive sites using a novel ligation-mediated amplification technique. Nucleic Acids Res (2007) 1.03
Human embryonic stem cells: an in vitro model to study mechanisms controlling pluripotency in early mammalian development. Stem Cell Rev (2005) 1.02
Organized development from human embryonic stem cells after injection into immunodeficient mice. Stem Cells Dev (2004) 1.01
In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency. Cell Rep (2013) 1.00
Embryonic stem cell therapy for diabetes mellitus. Semin Cell Dev Biol (2007) 0.99
Overexpression of Nodal promotes differentiation of mouse embryonic stem cells into mesoderm and endoderm at the expense of neuroectoderm formation. Stem Cells Dev (2005) 0.98
Injection of human mesenchymal stem cells improves healing of scarred vocal folds: analysis using a xenograft model. Laryngoscope (2010) 0.98
Lentiviral-mediated HoxB4 expression in human embryonic stem cells initiates early hematopoiesis in a dose-dependent manner but does not promote myeloid differentiation. Stem Cells (2008) 0.97
Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS One (2012) 0.96
A practical and efficient cellular substrate for the generation of induced pluripotent stem cells from adults: blood-derived endothelial progenitor cells. Stem Cells Transl Med (2012) 0.95
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells (2009) 0.93
Differentiation of human embryonic stem cells into osteogenic or hematopoietic lineages: a dose-dependent effect of osterix over-expression. J Cell Physiol (2009) 0.93
Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts. Stem Cells (2010) 0.93
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair. PLoS One (2012) 0.93
Nodal expression and detection in cancer: experience and challenges. Cancer Res (2012) 0.92
Popular computational methods to assess multiprotein complexes derived from label-free affinity purification and mass spectrometry (AP-MS) experiments. Mol Cell Proteomics (2012) 0.92
NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice. J Immunol (2008) 0.90
Human pluripotent stem cells for modelling human liver diseases and cell therapy. Curr Gene Ther (2013) 0.90
The serpinopathies studying serpin polymerization in vivo. Methods Enzymol (2011) 0.89
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol (2011) 0.88
Concise review: Cord blood banking, transplantation and induced pluripotent stem cell: success and opportunities. Stem Cells (2012) 0.88
Novel deletion variants of 9q13-q21.12 and classical euchromatic variants of 9q12/qh involve deletion, duplication and triplication of large tracts of segmentally duplicated pericentromeric euchromatin. Eur J Hum Genet (2006) 0.87
Trisomy 12 in HESC leads to no selective in vivo growth advantage in teratomas, but induces an increased abundance of renal development. J Cell Biochem (2007) 0.87
Status of genomic imprinting in epigenetically distinct pluripotent stem cells. Stem Cells (2012) 0.87
Melatonin promotes the cumulus-oocyte complexes quality of vitrified-thawed murine ovaries; with increased mean number of follicles survival and ovary size following heterotopic transplantation. Eur J Pharmacol (2009) 0.87