Published in Cell Stem Cell on May 02, 2013
Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature (2014) 1.91
Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell (2014) 1.81
INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development. Cell Stem Cell (2014) 1.22
Molecular control of induced pluripotency. Cell Stem Cell (2014) 1.22
Dynamic stem cell states: naive to primed pluripotency in rodents and humans. Nat Rev Mol Cell Biol (2016) 1.07
Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. J R Soc Interface (2014) 1.04
Network plasticity of pluripotency transcription factors in embryonic stem cells. Nat Cell Biol (2015) 1.03
Mapping the route from naive pluripotency to lineage specification. Philos Trans R Soc Lond B Biol Sci (2014) 1.01
Stability of the hybrid epithelial/mesenchymal phenotype. Oncotarget (2016) 0.99
Do all roads lead to Oct4? the emerging concepts of induced pluripotency. Trends Cell Biol (2013) 0.98
Role of Oct4 in the early embryo development. Cell Regen (Lond) (2014) 0.94
The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Curr Opin Genet Dev (2013) 0.93
Oct transcription factors in development and stem cells: insights and mechanisms. Development (2013) 0.91
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci (2015) 0.90
Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency. Nat Commun (2014) 0.89
A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells. Mol Syst Biol (2013) 0.89
Gene expression variability as a unifying element of the pluripotency network. Stem Cell Reports (2014) 0.88
Chromatin features and the epigenetic regulation of pluripotency states in ESCs. Development (2014) 0.88
Coupling the modules of EMT and stemness: A tunable 'stemness window' model. Oncotarget (2015) 0.86
An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. Biol Open (2014) 0.86
Age-related yield of adipose-derived stem cells bearing the low-affinity nerve growth factor receptor. Stem Cells Int (2013) 0.85
A model-based analysis of culture-dependent phenotypes of mESCs. PLoS One (2014) 0.85
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4. Cell Rep (2016) 0.85
Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells. Genome Res (2015) 0.84
Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Philos Trans R Soc Lond B Biol Sci (2014) 0.84
A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation. PLoS Biol (2014) 0.83
Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions. PLoS One (2014) 0.83
Microfluidic isolation of highly pure embryonic stem cells using feeder-separated co-culture system. Sci Rep (2013) 0.82
MCA: Multiresolution Correlation Analysis, a graphical tool for subpopulation identification in single-cell gene expression data. BMC Bioinformatics (2014) 0.82
Toward pluripotency by reprogramming: mechanisms and application. Protein Cell (2013) 0.81
From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis. Philos Trans R Soc Lond B Biol Sci (2014) 0.81
Nanog, Oct4 and Tet1 interplay in establishing pluripotency. Sci Rep (2016) 0.79
Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells. Semin Cell Dev Biol (2015) 0.79
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
RNA-binding proteins in pluripotency, differentiation, and reprogramming. Front Biol (Beijing) (2014) 0.78
Large-scale time-lapse microscopy of Oct4 expression in human embryonic stem cell colonies. Stem Cell Res (2016) 0.77
OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm. Stem Cell Reports (2015) 0.77
Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4. Stem Cells Int (2015) 0.77
Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubs. BMC Bioinformatics (2014) 0.76
The emerging roles of Oct4 in tumor-initiating cells. Am J Physiol Cell Physiol (2015) 0.76
Gene expression variability in mammalian embryonic stem cells using single cell RNA-seq data. Comput Biol Chem (2016) 0.75
Multi-layered global gene regulation in mouse embryonic stem cells. Cell Mol Life Sci (2014) 0.75
ISSCR 2013: back to Bean Town. Stem Cell Reports (2013) 0.75
TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells Int (2015) 0.75
Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Cell Rep (2016) 0.75
Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of Cancer. Front Oncol (2015) 0.75
A Dynamic Role of TBX3 in the Pluripotency Circuitry. Stem Cell Reports (2015) 0.75
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus. PLoS Genet (2017) 0.75
Pluripotency Factors on Their Lineage Move. Stem Cells Int (2015) 0.75
Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency. Oxid Med Cell Longev (2017) 0.75
Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells Int (2017) 0.75
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet (2000) 21.52
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development (1996) 7.00
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
Changing potency by spontaneous fusion. Nature (2002) 6.46
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62
Identification and characterization of subpopulations in undifferentiated ES cell culture. Development (2008) 5.55
Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell (2008) 5.47
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature (2009) 5.46
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev (1995) 5.42
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells (2007) 4.04
Improved automatic detection and segmentation of cell nuclei in histopathology images. IEEE Trans Biomed Eng (2009) 4.01
Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol (2005) 3.97
Stochastic patterning in the mouse pre-implantation embryo. Development (2007) 3.83
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells. Nature (2009) 3.43
Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol Cell Biol (1997) 3.34
The ground state of pluripotency. Biochem Soc Trans (2010) 3.24
The transcriptional foundation of pluripotency. Development (2009) 3.21
Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell (2012) 2.93
Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells. Biochem Biophys Res Commun (2006) 2.76
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development (2010) 2.60
Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell (2010) 2.58
WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol (2005) 2.54
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. Cell Cycle (2011) 2.45
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
Control of ground-state pluripotency by allelic regulation of Nanog. Nature (2012) 2.25
Pluripotential competence of cells associated with Nanog activity. Mech Dev (2005) 2.01
Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol (2008) 1.95
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol Cell Biol (2006) 1.69
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37
The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development (2012) 1.33
Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS One (2010) 1.29
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U S A (2012) 1.26
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23
Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev Biol (1998) 0.96
Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice. Genesis (2003) 0.89
Maintenance of pluripotential embryonic stem cells by stem cell selection. Reprod Fertil Dev (1998) 0.85
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
The transcriptional foundation of pluripotency. Development (2009) 3.21
Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell (2009) 3.02
Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell (2012) 2.93
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Molecular coupling of Xist regulation and pluripotency. Science (2008) 2.74
Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Mol Cell Biol (2002) 2.68
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell (2013) 2.06
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04
The pluripotency rheostat Nanog functions as a dimer. Biochem J (2008) 1.97
Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol (2008) 1.95
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature (2013) 1.82
Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell (2007) 1.77
p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem (2004) 1.70
Molecular coupling of Tsix regulation and pluripotency. Nature (2010) 1.69
Localized plasticity in the streamlined genomes of vinyl chloride respiring Dehalococcoides. PLoS Genet (2009) 1.61
Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles. Nat Biotechnol (2003) 1.57
GeneProf: analysis of high-throughput sequencing experiments. Nat Methods (2011) 1.48
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature (2013) 1.48
In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Cell Rep (2012) 1.45
In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures. Dev Cell (2013) 1.43
Molecular framework underlying pluripotency. Cell Cycle (2008) 1.42
KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells (2009) 1.39
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34
The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development (2012) 1.33
Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells (2008) 1.27
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development (2014) 1.26
Tissue, cell and stage specificity of (epi)mutations in cancers. Nat Rev Cancer (2005) 1.24
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23
Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells. Stem Cells (2013) 1.18
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J (2013) 1.16
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data. PLoS One (2009) 1.13
Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Proc Natl Acad Sci U S A (2008) 1.13
A new C-type lectin similar to the human immunoreceptor DC-SIGN mediates symbiont acquisition by a marine nematode. Appl Environ Microbiol (2006) 1.10
Cultured cambial meristematic cells as a source of plant natural products. Nat Biotechnol (2010) 1.06
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Hum Genet (2011) 1.04
Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells. Mol Cell (2013) 1.03
BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci U S A (2007) 1.03
A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl (2010) 1.01
A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells (2013) 1.01
Dynamics of thymus organogenesis and colonization in early human development. Development (2013) 0.94
Innate-like effector differentiation of human invariant NKT cells driven by IL-7. J Immunol (2008) 0.94
The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Curr Opin Genet Dev (2013) 0.93
Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. Development (2006) 0.93
TGFbeta and SMADs talk to NANOG in human embryonic stem cells. Cell Stem Cell (2008) 0.92
Transcription factor heterogeneity and epiblast pluripotency. Philos Trans R Soc Lond B Biol Sci (2011) 0.92
A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLoS One (2010) 0.89
Transcriptional and epigenetic regulations of embryonic stem cells. Mutat Res (2008) 0.88
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes Dev (2012) 0.87
Transcriptional regulatory networks in embryonic stem cells. Prog Drug Res (2011) 0.86