Published in Proc Natl Acad Sci U S A on June 13, 2003
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput Biol (2006) 2.30
Caspases: pharmacological manipulation of cell death. J Clin Invest (2005) 2.10
Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells. Cancer Biol Ther (2010) 1.55
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. J Mol Biol (2009) 1.41
Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J Neuroendocrinol (2009) 0.99
Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models. Cell Death Dis (2011) 0.95
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev (2009) 0.94
Bioactivity of the Murex Homeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer Cells. Evid Based Complement Alternat Med (2010) 0.91
Caspases as therapeutic targets. J Cell Mol Med (2008) 0.89
Purified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines. Mar Drugs (2013) 0.87
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Rep (2015) 0.85
Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol (2013) 0.85
Caspases shutdown nonsense-mediated mRNA decay during apoptosis. Cell Death Differ (2015) 0.82
Induced neural stem cells protect neuronal cells against apoptosis. Med Sci Monit (2014) 0.78
Apoptogenic metabolites in fractions of the Benthic diatom Cocconeis scutellum parva. Mar Drugs (2014) 0.78
Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung. Int J Oncol (2014) 0.75
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Mitochondria and apoptosis. Science (1998) 23.41
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
The expanding role of mitochondria in apoptosis. Genes Dev (2001) 9.91
Apoptosis: a link between cancer genetics and chemotherapy. Cell (2002) 7.86
Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem (1998) 6.84
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24
Apoptosis in cancer. Carcinogenesis (2000) 5.49
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell (1998) 5.06
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science (2002) 4.80
Apoptotic pathways: paper wraps stone blunts scissors. Cell (2000) 4.37
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol (2001) 3.03
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J (1999) 2.45
Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem (2000) 2.42
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem (2001) 2.06
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem (1999) 1.96
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J Biol Chem (2000) 1.94
Chemical genetic approaches for the elucidation of signaling pathways. Curr Opin Chem Biol (2001) 1.39
Death by design: mechanism and control of apoptosis. Trends Cell Biol (1999) 1.33
Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res (2002) 1.13
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. J Biol Chem (2001) 1.11
Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. Proc Natl Acad Sci U S A (1998) 0.97
Signaling pathways in apoptosis as potential targets for cancer therapy. Trends Cell Biol (2001) 0.88
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov (2004) 7.84
Repairing research integrity. Nature (2008) 5.91
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature (2013) 4.43
Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell (2008) 4.00
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell (2013) 2.41
Tethering: fragment-based drug discovery. Annu Rev Biophys Biomol Struct (2004) 2.37
Searching for new allosteric sites in enzymes. Curr Opin Struct Biol (2004) 2.31
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell (2010) 1.85
Caspase substrates and cellular remodeling. Annu Rev Biochem (2011) 1.79
Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A (2003) 1.78
Small-molecule activators of a proenzyme. Science (2009) 1.72
Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol (2013) 1.68
Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics (2010) 1.57
Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A (2006) 1.47
Turning enzymes ON with small molecules. Nat Chem Biol (2010) 1.47
Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE (2004) 1.42
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A (2012) 1.36
The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics (2012) 1.34
Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A (2011) 1.33
Sampling the N-terminal proteome of human blood. Proc Natl Acad Sci U S A (2010) 1.28
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.23
Global cellular response to chemotherapy-induced apoptosis. Elife (2013) 1.19
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc (2011) 1.14
Malonate-assisted purification of human caspases. Protein Expr Purif (2005) 1.12
Methods for the proteomic identification of protease substrates. Curr Opin Chem Biol (2009) 1.07
Prediction of protease substrates using sequence and structure features. Bioinformatics (2010) 1.04
Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc (2003) 1.02
Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proc Natl Acad Sci U S A (2012) 1.02
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem (2009) 1.00
Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc (2013) 0.97
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem (2012) 0.97
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell (2012) 0.97
Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem (2004) 0.96
Molecules that modulate Apaf-1 activity. Med Res Rev (2010) 0.92
Tags for labeling protein N-termini with subtiligase for proteomics. Bioorg Med Chem Lett (2008) 0.91
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A (2013) 0.91
Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun (2004) 0.89
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem (2013) 0.82
Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem (2011) 0.81
Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des (2011) 0.76
Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol (2016) 0.76
Computational approach to site-directed ligand discovery. Proteins (2007) 0.76
Warren L. DeLano 21 June 1972-3 November 2009. Nat Struct Mol Biol (2009) 0.75
Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. J Am Chem Soc (2017) 0.75
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. bioRxiv (2020) 0.75
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv (2020) 0.75
Regulated cell death part A: apoptotic mechanisms. Preface. Methods Enzymol (2014) 0.75
Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. Methods Enzymol (2014) 0.75
Next generation therapeutics. Curr Opin Chem Biol (2013) 0.75