Published in Genes Dev on May 01, 2013
Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis (2013) 0.99
p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia. Br J Cancer (2013) 0.82
ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Cancer Cell (2016) 0.76
Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis. Genes Dev (2016) 0.76
The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy. Br J Cancer (2016) 0.75
Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy. Mol Ther Oncolytics (2017) 0.75
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47
Autophagy and metabolism. Science (2010) 8.10
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (2002) 4.56
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 3.52
Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif (2012) 3.18
Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem (2011) 3.15
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08
Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis (2012) 1.67
DRAM links autophagy to p53 and programmed cell death. Autophagy (2007) 1.60
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ (2007) 1.39
A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol (2008) 1.34
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
Autophagy in protists. Autophagy (2011) 1.29
Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol (2012) 1.25
Autophagy revisited: a conversation with Christian de Duve. Autophagy (2008) 1.24
Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle (2012) 1.23
Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases. Autophagy (2012) 1.16
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A (2002) 2.24
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
ΔNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle (2010) 1.57
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J (2009) 1.54
p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell (2007) 1.41
p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet (2009) 1.41
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest (2012) 1.29
The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem (2012) 1.19
Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res (2003) 1.11
Li-Fraumeni syndrome: a p53 family affair. Cell Cycle (2005) 1.05
BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. Elife (2013) 1.02
p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci (2013) 0.99
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8. Proc Natl Acad Sci U S A (2014) 0.92
Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. Mol Cancer Res (2011) 0.91
SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol Cell Biol (2011) 0.88
Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A (2013) 0.88
Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings. Am J Pathol (2011) 0.82
Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress. Free Radic Biol Med (2013) 0.78
TAp63: The fountain of youth. Aging (Albany NY) (2009) 0.78
IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity. J Biol Chem (2013) 0.77