Published in Structure on June 20, 2013
Identification of key residues and regions important for porcupine-mediated Wnt acylation. J Biol Chem (2014) 1.02
Disulfide bond requirements for active Wnt ligands. J Biol Chem (2014) 0.94
Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep (2015) 0.90
Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm. PLoS One (2014) 0.87
Fatty acylation of Wnt proteins. Nat Chem Biol (2016) 0.87
Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity. BMC Biol (2014) 0.86
Updating the Wnt pathways. Biosci Rep (2014) 0.86
Wnt acylation and its functional implication in Wnt signalling regulation. Biochem Soc Trans (2015) 0.80
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. Mol Cell (2016) 0.79
Isolation and characterization of recombinant murine Wnt3a. Protein Expr Purif (2014) 0.77
Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies. Drug Des Devel Ther (2015) 0.76
Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants. BMC Biol (2016) 0.75
Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cells. J Nanobiotechnology (2016) 0.75
Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep (2017) 0.75
Identification of a Novel Nematotoxic Protein by Challenging the Model Mushroom Coprinopsis cinerea with a Fungivorous Nematode. G3 (Bethesda) (2015) 0.75
Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a. Arch Biochem Biophys (2017) 0.75
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Dali server: conservation mapping in 3D. Nucleic Acids Res (2010) 24.29
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Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74
CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res (2006) 9.19
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. Genes Dev (1996) 2.13
Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem (2002) 1.84
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature (2005) 1.75
Wnt proteins. Cold Spring Harb Perspect Biol (2012) 1.70
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol (2011) 1.68
Notch is required for wingless signaling in the epidermis of Drosophila. Cell (1994) 1.67
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem (2010) 1.63
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development (2005) 1.51
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Dev Cell (2011) 1.50
Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (2011) 1.34
Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol (2003) 1.30
Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. Genetics (1995) 1.13
Structural architecture and functional evolution of Wnts. Dev Cell (2012) 0.97
A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One (2011) 0.83
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
Wnt/β-catenin signaling and disease. Cell (2012) 16.05
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics (2004) 9.98
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science (2002) 6.35
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem (2006) 6.32
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18
Towards an integrated view of Wnt signaling in development. Development (2009) 6.07
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83
Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (2003) 3.52
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19
Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell (2012) 3.17
A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol (2002) 3.09
Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol (2007) 2.86
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83
A localized Wnt signal orients asymmetric stem cell division in vitro. Science (2013) 2.82
E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82
An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J (2013) 2.70
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science (2013) 2.52
Alternative wnt signaling is initiated by distinct receptors. Sci Signal (2008) 2.52
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell (2008) 2.37
Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33
Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31
Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One (2010) 2.28
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13
A critical role for endocytosis in Wnt signaling. BMC Cell Biol (2006) 2.09
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97
Wnt signaling mediates regional specification in the vertebrate face. Development (2007) 1.89
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell (2002) 1.88
Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development (2008) 1.87
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86
A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev (2008) 1.85
Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem (2002) 1.84
AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81
Wnt proteins promote bone regeneration. Sci Transl Med (2010) 1.80
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature (2005) 1.75
Wnt proteins. Cold Spring Harb Perspect Biol (2012) 1.70
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation. Chem Biol (2014) 1.69
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology (2007) 1.66
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nat Commun (2012) 1.63
Bone regeneration is regulated by wnt signaling. J Bone Miner Res (2007) 1.63
X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr (2009) 1.60
A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods (2007) 1.60
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell (2013) 1.58
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55
Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem (2004) 1.53
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res (2004) 1.53
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem (2009) 1.52
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS One (2007) 1.50
Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48
Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid. Nat Protoc (2007) 1.47
LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res (2004) 1.45
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics (2002) 1.39
Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev Dyn (2006) 1.38