Published in Clin Med Insights Oncol on June 03, 2013
The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models. Front Oncol (2014) 0.96
AKT in cancer: new molecular insights and advances in drug development. Br J Clin Pharmacol (2016) 0.90
Novel Molecular Markers for Breast Cancer. Biomark Cancer (2016) 0.80
Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu. Int J Cancer (2016) 0.75
Clinical applications of mouse models for breast cancer engaging HER2/neu. Integr Cancer Sci Ther (2016) 0.75
Haploinsufficient tumor suppressor genes. Adv Med Biol (2017) 0.75
Surfing the p53 network. Nature (2000) 35.36
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82
Pten is essential for embryonic development and tumour suppression. Nat Genet (1998) 13.41
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell (2004) 10.89
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res (2005) 8.98
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell (2003) 8.11
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell (1996) 7.46
The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A (1995) 7.31
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet (2009) 7.26
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02
The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol (2008) 6.62
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med (2011) 6.21
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet (2001) 5.92
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A (2007) 5.44
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science (1999) 5.09
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A (2001) 4.60
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell (2011) 4.43
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res (1998) 4.33
Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30
Impaired Fas response and autoimmunity in Pten+/- mice. Science (1999) 4.25
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell (1998) 4.22
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19
Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene (2006) 4.14
The ARF/p53 pathway. Curr Opin Genet Dev (2000) 4.13
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science (1999) 4.08
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet (2007) 3.95
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature (2000) 3.65
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J (2002) 3.45
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A (2003) 3.34
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A (1994) 3.33
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res (1999) 3.29
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest (2010) 3.09
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A (1995) 3.06
Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem (2002) 3.01
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2002) 2.89
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A (1998) 2.51
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci U S A (2001) 2.50
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther (2011) 2.50
Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res (2012) 2.45
Dissecting p53-dependent apoptosis. Cell Death Differ (2006) 2.44
Inducible gene knockouts in the small intestinal and colonic epithelium. J Biol Chem (1999) 2.28
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res (2007) 2.19
Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res (2005) 2.19
Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines. J Biol Chem (1999) 2.15
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res (2008) 2.15
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J Pathol (2009) 2.13
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res (2003) 2.11
Mutation analysis of the PTEN/MMAC1 gene in lung cancer. Oncogene (1998) 2.10
Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest (2012) 2.03
Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol (2011) 1.98
PTEN signaling pathways in melanoma. Oncogene (2003) 1.98
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev (1999) 1.95
p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell (2006) 1.90
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet (1997) 1.85
Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85
Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest (2004) 1.82
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet (1997) 1.76
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell (2012) 1.75
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell (2011) 1.74
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell (2010) 1.71
ATM and breast cancer susceptibility. Oncogene (2006) 1.68
Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. Hum Genet (1996) 1.67
SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res (2010) 1.64
Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest (2012) 1.63
Genetic background controls tumor development in PTEN-deficient mice. Cancer Res (2006) 1.63
Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res (2006) 1.62
Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A (2000) 1.54
Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. Dev Dyn (1995) 1.50
Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer. Endocr Relat Cancer (2003) 1.43
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell (2007) 1.17
Classical and Novel Prognostic Markers for Breast Cancer and their Clinical Significance. Clin Med Insights Oncol (2010) 1.13
Tooth discoloration induced by endodontic materials: a literature review. Dent Traumatol (2012) 1.02
The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1. Int J Cancer (2010) 0.95
Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function. Cancer Res (2012) 0.93
Role of DMP1 and its future in lung cancer diagnostics. Expert Rev Mol Diagn (2008) 0.91
Emerging roles of DMP1 in lung cancer. Cancer Res (2008) 0.86
Atraumatic vertical tooth extraction: a proof of principle clinical study of a novel system. Oral Surg Oral Med Oral Pathol Oral Radiol (2012) 0.86
Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. Am J Pathol (2013) 0.86
Transgenic and knockout mice models to reveal the functions of tumor suppressor genes. Clin Med Insights Oncol (2011) 0.85
Dmp1α inhibits HER2/neu-induced mammary tumorigenesis. PLoS One (2013) 0.84
Antigenotoxic potential of certain dietary constituents. Teratog Carcinog Mutagen (2003) 0.83
Signal transduction involving the dmp1 transcription factor and its alteration in human cancer. Clin Med Oncol (2008) 0.82
DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol (2015) 0.81
Alterations of p63 and p73 in human cancers. Subcell Biochem (2014) 0.81
Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice. Cancer Lett (2002) 0.79
Antimutagenic effects of garlic extract on chromosomal aberrations. Cancer Lett (2002) 0.78
Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats. Mutat Res (2002) 0.77
What's new in... the management of post-operative pain in dentistry. SAAD Dig (2015) 0.77
Mutagenic potential of Mancozeb in Salmonella typhimurium. J Environ Pathol Toxicol Oncol (2004) 0.75
Defining Over-Sedation: Literature Review and National Survey of Dental Hospitals Within the United Kingdom. SAAD Dig (2016) 0.75
Iatrosedation: a holistic tool in the armamentarium of anxiety control. SAAD Dig (2015) 0.75