Published in Nature on April 30, 2009
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell (2012) 4.11
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 3.70
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
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Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest (2011) 2.23
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The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Differ (2012) 1.20
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Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J Biol Chem (2011) 1.13
The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther (2010) 1.11
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p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol (2010) 1.10
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Stem cells: balancing resistance and sensitivity to DNA damage. Trends Cell Biol (2014) 1.09
Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1. J Biol Chem (2012) 1.08
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Autophagy in pancreatic cancer pathogenesis and treatment. Am J Cancer Res (2012) 1.07
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DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC Biol (2013) 1.06
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In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J Am Chem Soc (2013) 1.06
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle (2011) 1.06
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SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ (2010) 1.04
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Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A (2013) 0.98
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Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PLoS One (2012) 0.97
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PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem (2010) 0.96
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J Biol Chem (2011) 0.95
Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner. PLoS One (2013) 0.95
bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS One (2013) 0.94
Selective killing of p53-deficient cancer cells by SP600125. EMBO Mol Med (2012) 0.94
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. J Biol Chem (2011) 0.93
Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells. World J Surg Oncol (2013) 0.93
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. Exp Gerontol (2009) 0.93
ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Mol Cancer (2010) 0.92
Regulated unfolding of proteins in signaling. FEBS Lett (2013) 0.92
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses. Mol Cancer (2013) 0.91
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Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid Med Cell Longev (2013) 0.91
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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47
p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
BAX activation is initiated at a novel interaction site. Nature (2008) 6.07
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol (2004) 5.56
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science (2005) 5.49
Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer (2008) 5.35
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Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
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GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell (2007) 4.22
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p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res (2008) 2.27
p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction. Oncogene (2006) 2.04
Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle (2008) 2.03
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell (2003) 1.88
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest (2007) 1.71
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell (2008) 1.66
The effects of p53 on whole organism longevity are mediated by autophagy. Autophagy (2008) 1.63
Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem (2008) 1.55
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s. Cancer Res (2005) 1.43
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Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J Biol Chem (2007) 1.23
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc Natl Acad Sci U S A (2008) 1.05
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia. Biochem Soc Trans (2006) 1.02
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