Published in J Biol Chem on August 28, 2013
Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism. Front Pharmacol (2014) 0.99
Genetically modifying the insect gut microbiota to control Chagas disease vectors through systemic RNAi. PLoS Negl Trop Dis (2015) 0.84
Toll signals regulate dorsal-ventral patterning and anterior-posterior placement of the embryo in the hemipteran Rhodnius prolixus. Evodevo (2014) 0.81
Acquisition of exogenous haem is essential for tick reproduction. Elife (2016) 0.79
First report of Y-linked genes in the kissing bug Rhodnius prolixus. BMC Genomics (2016) 0.75
Eggshell ultrastructure and delivery of pharmacological inhibitors to the early embryo of R. prolixus by ethanol permeabilization of the extraembryonic layers. PLoS One (2017) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250. Electrophoresis (1988) 9.38
Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev (1990) 5.94
Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37
Draft genome of the filarial nematode parasite Brugia malayi. Science (2007) 5.28
Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci U S A (1999) 4.40
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol (2012) 2.75
Cell biology of heme. Am J Med Sci (1999) 2.51
Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol (2000) 2.45
HEMIN BIOSYNTHESIS IN HAEMOPHILUS. J Bacteriol (1963) 2.38
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proc Natl Acad Sci U S A (1993) 2.07
Adaptations against heme toxicity in blood-feeding arthropods. Insect Biochem Mol Biol (2006) 2.03
Lack of heme synthesis in a free-living eukaryote. Proc Natl Acad Sci U S A (2005) 1.95
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
Regulation by heme of mitochondrial protein transport through a conserved amino acid motif. Science (1993) 1.79
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases. Cell Res (2006) 1.79
Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci U S A (1999) 1.64
Unsaturated lipide oxidation catalyzed by hematin compounds. J Biol Chem (1955) 1.58
Mitochondrial transporters as novel targets for intracellular calcium signaling. Physiol Rev (2007) 1.57
Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J (1988) 1.53
One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans. Biochim Biophys Acta (2012) 1.46
Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol (2007) 1.43
Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39
Hemin lyses malaria parasites. Science (1981) 1.36
Hemin-mediated oxidative degradation of proteins. J Biol Chem (1984) 1.28
Oxidative effects of heme and porphyrins on proteins and lipids. Semin Hematol (1989) 1.28
Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production. Development (2004) 1.23
Hemin-mediated DNA strand scission. J Biol Chem (1983) 1.21
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. J Biol Chem (2000) 1.13
Hemin-induced lipid membrane disorder and increased permeability: a molecular model for the mechanism of cell lysis. Arch Biochem Biophys (1993) 1.13
Calcium signals and mitochondria at fertilisation. Semin Cell Dev Biol (2006) 1.03
A missing metabolic pathway in the cattle tick Boophilus microplus. Curr Biol (1999) 1.03
A heme-degradation pathway in a blood-sucking insect. Proc Natl Acad Sci U S A (2006) 1.01
An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell (2011) 1.00
Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genet (2010) 0.99
HeLp, a heme lipoprotein from the hemolymph of the cattle tick, Boophilus microplus. J Biol Chem (2000) 0.97
Antioxidant role of Rhodnius prolixus heme-binding protein. Protection against heme-induced lipid peroxidation. J Biol Chem (1995) 0.94
A heme-binding protein from hemolymph and oocytes of the blood-sucking insect, Rhodnius prolixus. Isolation and characterization. J Biol Chem (1995) 0.91
Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme-responsive gene-2. J Biol Chem (2012) 0.89
Atlantic hagfish cardiac muscle: metabolic basis of tolerance to anoxia. Am J Physiol (1983) 0.89
Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization. Mol Reprod Dev (2012) 0.87
On the biosynthesis of Rhodnius prolixus heme-binding protein. Insect Biochem Mol Biol (2002) 0.86
Uptake of Rhodnius heme-binding protein (RHBP) by the ovary of Rhodnius prolixus. Arch Insect Biochem Physiol (1998) 0.83
Rhodnius heme-binding protein (RHBP) is a heme source for embryonic development in the blood-sucking bug Rhodnius prolixus (Hemiptera, Reduviidae). Insect Biochem Mol Biol (2002) 0.82
The effect of nutrient intake on the development and the egg production of Rhodnius prolixus Ståhl (Hemiptera: Reduviidae). Can J Zool (1965) 0.82
RNA synthesis in isolated mitochondria from sea urchin embryos. Cell Differ (1974) 0.81
Calcium-regulated fusion of yolk granules during early embryogenesis of Periplaneta americana. Mol Reprod Dev (2006) 0.79
Heme biosynthesis and oogenesis in the blood-sucking bug, Rhodnius prolixus. Insect Biochem Mol Biol (2001) 0.78
Calcium-regulated fusion of yolk granules is important for yolk degradation during early embryogenesis of Rhodnius prolixus Stahl. J Exp Biol (2007) 0.78
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Characterization of heme as activator of Toll-like receptor 4. J Biol Chem (2007) 2.38
Adaptations against heme toxicity in blood-feeding arthropods. Insect Biochem Mol Biol (2006) 2.03
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood (2013) 1.74
Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. J Biol Chem (2004) 1.59
Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog (2011) 1.57
Origin and evolution of Y chromosomes: Drosophila tales. Trends Genet (2009) 1.53
Neutrophil activation by heme: implications for inflammatory processes. Blood (2002) 1.49
Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5'-triphosphate synthase activity. Crit Care Med (2011) 1.33
Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein. Biochemistry (2006) 1.32
Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus. FEBS Lett (2005) 1.27
Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion. Insect Biochem Mol Biol (2002) 1.25
Sepsis induces brain mitochondrial dysfunction. Crit Care Med (2008) 1.21
Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy. PLoS Pathog (2010) 1.18
Two new Y-linked genes in Drosophila melanogaster. Genetics (2008) 1.12
The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. Free Radic Biol Med (2009) 1.09
Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection. J Infect Dis (2004) 1.08
A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome. J Exp Biol (2003) 1.07
Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity. J Biol Chem (2006) 1.06
Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis (2009) 1.06
Extracellular lipid droplets promote hemozoin crystallization in the gut of the blood fluke Schistosoma mansoni. FEBS Lett (2007) 1.01
A heme-degradation pathway in a blood-sucking insect. Proc Natl Acad Sci U S A (2006) 1.01
Blood-feeding induces reversible functional changes in flight muscle mitochondria of Aedes aegypti mosquito. PLoS One (2009) 0.98
Changes in salivary nitrophorin profile during the life cycle of the blood-sucking bug Rhodnius prolixus. Insect Biochem Mol Biol (2003) 0.98
A chitin-like component in Aedes aegypti eggshells, eggs and ovaries. Insect Biochem Mol Biol (2007) 0.98
Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection. Insect Biochem Mol Biol (2011) 0.96
Oxidative stress impairs heme detoxification in the midgut of the cattle tick, Rhipicephalus (Boophilus) microplus. Mol Biochem Parasitol (2006) 0.95
Azathioprine inhibits vaccinia virus replication in both BSC-40 and RAG cell lines acting on different stages of virus cycle. Virology (2002) 0.93
On the fate of extracellular hemoglobin and heme in brain. J Cereb Blood Flow Metab (2009) 0.90
Heme crystallization in the midgut of triatomine insects. Comp Biochem Physiol C Toxicol Pharmacol (2006) 0.90
Biglutaminyl-biliverdin IX alpha as a heme degradation product in the dengue fever insect-vector Aedes aegypti. Biochemistry (2007) 0.89
Effects of retinoids and juvenoids on moult and on phenoloxidase activity in the blood-sucking insect Rhodnius prolixus. Acta Trop (2007) 0.89
Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues. Biochimie (2008) 0.88
Vampires, Pasteur and reactive oxygen species. Is the switch from aerobic to anaerobic metabolism a preventive antioxidant defence in blood-feeding parasites? FEBS Lett (2002) 0.88
Olfactory ensheathing cells as putative host cells for Streptococcus pneumoniae: evidence of bacterial invasion via mannose receptor-mediated endocytosis. Neurosci Res (2010) 0.88
On the mechanisms involved in biological heme crystallization. J Bioenerg Biomembr (2011) 0.87
HeLp, a heme-transporting lipoprotein with an antioxidant role. Insect Biochem Mol Biol (2004) 0.87
Proton-pyrophosphatase and polyphosphate in acidocalcisome-like vesicles from oocytes and eggs of Periplaneta americana. Insect Biochem Mol Biol (2008) 0.87
Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab (2009) 0.87
On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut. Insect Biochem Mol Biol (2010) 0.87
Vaccination of bovines with recombinant Boophilus Yolk pro-Cathepsin. Vet Immunol Immunopathol (2006) 0.87
On the pro-oxidant effects of haemozoin. FEBS Lett (2002) 0.87
The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal. PLoS One (2012) 0.86
Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection. PLoS One (2012) 0.86
Nandrolone decanoate impairs exercise-induced cardioprotection: role of antioxidant enzymes. J Steroid Biochem Mol Biol (2006) 0.85
The role of reactive oxygen species in Anopheles aquasalis response to Plasmodium vivax infection. PLoS One (2013) 0.85
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. PLoS One (2011) 0.84
Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS. PLoS One (2011) 0.84
In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping. Free Radic Biol Med (2013) 0.83
Trypanosoma brucei brucei: effects of ferrous iron and heme on ecto-nucleoside triphosphate diphosphohydrolase activity. Exp Parasitol (2008) 0.82
Perimicrovillar membranes promote hemozoin formation into Rhodnius prolixus midgut. Insect Biochem Mol Biol (2007) 0.82
Increase on the initial soluble heme levels in acidic conditions is an important mechanism for spontaneous heme crystallization in vitro. PLoS One (2010) 0.82
Rhodnius heme-binding protein (RHBP) is a heme source for embryonic development in the blood-sucking bug Rhodnius prolixus (Hemiptera, Reduviidae). Insect Biochem Mol Biol (2002) 0.82
Bioimaging of copper alterations in the aging mouse brain by autoradiography, laser ablation inductively coupled plasma mass spectrometry and immunohistochemistry. Metallomics (2010) 0.82
Antioxidant pathways are up-regulated during biological nitrogen fixation to prevent ROS-induced nitrogenase inhibition in Gluconacetobacter diazotrophicus. Arch Microbiol (2010) 0.82
Proteolytic activity of Boophilus microplus Yolk pro-Cathepsin D (BYC) is coincident with cortical acidification during embryogenesis. Insect Biochem Mol Biol (2004) 0.81
A comparative assessment of mitochondrial function in epimastigotes and bloodstream trypomastigotes of Trypanosoma cruzi. J Bioenerg Biomembr (2011) 0.81
Transcriptomic analyses of the avirulent protozoan parasite Trypanosoma rangeli. Mol Biochem Parasitol (2010) 0.81
An extraovarian aspartic protease accumulated in tick oocytes with vitellin-degradation activity. Comp Biochem Physiol B Biochem Mol Biol (2008) 0.81
Biology of Triatoma klugi Carcavallo, Jurberg, Lent & Galvão 2001 (Heteroptera: Reduviidae) under laboratory conditions: effects of distinct blood sources and susceptibility to Trypanosoma cruzi and Trypanosoma rangeli. Mem Inst Oswaldo Cruz (2002) 0.81
The putrescine analogue 1,4-diamino-2-butanone affects polyamine synthesis, transport, ultrastructure and intracellular survival in Leishmania amazonensis. Microbiology (2008) 0.80
Transcriptome and gene expression profile of ovarian follicle tissue of the triatomine bug Rhodnius prolixus. Insect Biochem Mol Biol (2011) 0.80
Microscopic and molecular characterization of ovarian follicle atresia in Rhodnius prolixus Stahl under immune challenge. J Insect Physiol (2011) 0.80
Serotonin regulates an acyl-CoA-binding protein (ACBP) gene expression in the midgut of Rhodnius prolixus. Insect Biochem Mol Biol (2010) 0.79
BYC, an atypical aspartic endopeptidase from Rhipicephalus (Boophilus) microplus eggs. Comp Biochem Physiol B Biochem Mol Biol (2007) 0.79
In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells. Cell Biol Int (2010) 0.79
Molecular, Cellular and Clinical Aspects of Intracerebral Hemorrhage: Are the Enemies Within? Curr Neuropharmacol (2016) 0.79
OKB, a novel family of brain-gut neuropeptides from insects. Insect Biochem Mol Biol (2012) 0.78
Interplay between acid phosphatase and cysteine proteases in mediating vitellin degradation during early embryogenesis of Periplaneta americana. J Insect Physiol (2008) 0.78
Exercise-induced cardioprotection is impaired by anabolic steroid treatment through a redox-dependent mechanism. J Steroid Biochem Mol Biol (2013) 0.77
Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing. J Biol Chem (2013) 0.77
Purification and antigenicity of two recombinant forms of Boophilus microplus yolk pro-cathepsin expressed in inclusion bodies. Protein Expr Purif (2005) 0.76
Cyclic nucleotide-independent phosphorylation of vitellin by casein kinase II purified from Rhodnius prolixus oocytes. Insect Biochem Mol Biol (2002) 0.76
Foreword. Mem Inst Oswaldo Cruz (2013) 0.75
Heparan sulfate glycosaminoglycan expression in the intestinal tract and ovary of fully engorged adult females of the cattle tick Boophilus microplus and in their laid eggs. Mol Biochem Parasitol (2003) 0.75
The role of eicosanoids on Rhodnius heme-binding protein (RHBP) endocytosis by Rhodnius prolixus ovaries. Insect Biochem Mol Biol (2002) 0.75