Published in Mol Cancer on September 25, 2013
Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling. J Cell Mol Med (2014) 0.87
Characterization of differentially expressed genes involved in pathways associated with gastric cancer. PLoS One (2015) 0.83
GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer. BMC Cancer (2016) 0.76
Downregulation of FBP1 Promotes Tumor Metastasis and Indicates Poor Prognosis in Gastric Cancer via Regulating Epithelial-Mesenchymal Transition. PLoS One (2016) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods (1995) 16.00
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
The two TORCs and Akt. Dev Cell (2007) 6.17
Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76
The AMP-activated protein kinase pathway--new players upstream and downstream. J Cell Sci (2004) 5.65
Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species. FASEB J (1997) 2.65
The epidemiology of gastric cancer. Gastric Cancer (2002) 2.58
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem (2005) 2.57
Helicobacter infection and gastric neoplasia. J Pathol (2006) 2.54
Cancer as a metabolic disease. Nutr Metab (Lond) (2010) 1.98
Nature meets nurture: molecular genetics of gastric cancer. Hum Genet (2009) 1.87
DNA methylation and microRNA dysregulation in cancer. Mol Oncol (2012) 1.69
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene (2009) 1.58
Molecular basis of gastric cancer development and progression. Gastric Cancer (2004) 1.49
Akt: versatile mediator of cell survival and beyond. J Biochem Mol Biol (2002) 1.43
Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer. PLoS One (2011) 1.14
Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells. Gynecol Oncol (2011) 1.02
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. Biochem Biophys Res Commun (2008) 0.93
Integration of statistical inference methods and a novel control measure to improve sensitivity and specificity of data analysis in expression profiling studies. J Biomed Inform (2007) 0.93
Localization and regulation of muscle fructose-1,6-bisphosphatase, the key enzyme of glyconeogenesis. Adv Enzyme Regul (2006) 0.86
The epigenetic basis of the Warburg effect. Epigenetics (2010) 0.85
Cancer, epigenetics and the Nobel Prizes. Mol Oncol (2012) 0.78
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
International network of cancer genome projects. Nature (2010) 20.35
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet (2002) 7.12
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping. Nature (2010) 3.53
CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res (2008) 3.40
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev (2003) 2.78
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer (2005) 2.42
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
Enols are common intermediates in hydrocarbon oxidation. Science (2005) 2.15
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS One (2008) 2.10
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet (2003) 2.09
Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res (2011) 2.00
Capnography monitoring in procedural sedation for bronchoscopy. J Bronchology Interv Pulmonol (2014) 2.00
Tuning upconversion through energy migration in core-shell nanoparticles. Nat Mater (2011) 2.00
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00
HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. J Clin Oncol (2012) 1.92
Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol (2010) 1.92
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res (2003) 1.90
Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry (2012) 1.85
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet (2005) 1.72
Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut (2010) 1.67
Find duplicates among the PubMed, EMBASE, and Cochrane Library Databases in systematic review. PLoS One (2013) 1.63
Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases. Bioinformatics (2010) 1.59
Human microRNA oncogenes and tumor suppressors show significantly different biological patterns: from functions to targets. PLoS One (2010) 1.59
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia (2006) 1.53
Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus. Cancer Prev Res (Phila) (2011) 1.53
Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol (2004) 1.52
Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology (2006) 1.52
TAM: a method for enrichment and depletion analysis of a microRNA category in a list of microRNAs. BMC Bioinformatics (2010) 1.49
Genome-scale transcriptome analysis of the desert poplar, Populus euphratica. Tree Physiol (2011) 1.47
Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol Cell Neurosci (2002) 1.47
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45
Unconventional protein secretion. Trends Plant Sci (2012) 1.44
Prevalence and risk factors of urinary incontinence for post-stroke inpatients in Southern China. Neurourol Urodyn (2013) 1.42
TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol Pain (2011) 1.38
Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells. Biochem Biophys Res Commun (2010) 1.37
High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B. PLoS One (2011) 1.36
Direct evidence of a surface quenching effect on size-dependent luminescence of upconversion nanoparticles. Angew Chem Int Ed Engl (2010) 1.35
Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin Chem (2003) 1.34
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol (2009) 1.34
Multiorgan engraftment and differentiation of human cord blood CD34+ Lin- cells in goats assessed by gene expression profiling. Proc Natl Acad Sci U S A (2006) 1.33
Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis. Nat Genet (2012) 1.31
Genomic insights into salt adaptation in a desert poplar. Nat Commun (2013) 1.30
Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci U S A (2011) 1.30
Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. Proc Natl Acad Sci U S A (2009) 1.29
An atlas of DNA methylomes in porcine adipose and muscle tissues. Nat Commun (2012) 1.28
Primary hepatic diffuse large B cell lymphoma: A case report: Primary hepatic diffuse large B cell lymphoma. Hepat Mon (2011) 1.27
Activation of SOCS-3 by resistin. Mol Cell Biol (2005) 1.27
Which is the optimal biologically effective dose of stereotactic body radiotherapy for Stage I non-small-cell lung cancer? A meta-analysis. Int J Radiat Oncol Biol Phys (2011) 1.26
Distribution of the multidrug resistance gene cfr in Staphylococcus species isolates from swine farms in China. Antimicrob Agents Chemother (2011) 1.26
Target analysis by integration of transcriptome and ChIP-seq data with BETA. Nat Protoc (2013) 1.24
Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell (2006) 1.24
Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos (2008) 1.24
BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant J (2009) 1.22
Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer. Sci Transl Med (2013) 1.21
Angiotensin II AT1 receptor blockade ameliorates brain inflammation. Neuropsychopharmacology (2010) 1.21
Standard uptake value and metabolic tumor volume of ¹⁸F-FDG PET/CT predict short-term outcome early in the course of chemoradiotherapy in advanced non-small cell lung cancer. Eur J Nucl Med Mol Imaging (2011) 1.20
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem (2004) 1.19
Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment. Cancer Res (2004) 1.19
S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J (2010) 1.18
Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography. Nucleic Acids Res (2002) 1.18
Proteomic identification of differentially expressed proteins in the Ligon lintless mutant of upland cotton (Gossypium hirsutum L.). J Proteome Res (2010) 1.18
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis. Development (2012) 1.16
The sequence and analysis of a Chinese pig genome. Gigascience (2012) 1.15
"Pseudo" gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotic biosynthesis. J Biol Chem (2010) 1.14
Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. J Neurochem (2010) 1.13
Increased Golgi protein 73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival. J Gastroenterol Hepatol (2011) 1.13
Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling. J Genet Genomics (2011) 1.12
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling. J Biol Chem (2013) 1.12
TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice. PLoS One (2012) 1.12
Magnetic resonance imaging of ruptured spinal dermoid tumors with spread of fatty droplets in the central spinal canal and/or spinal subarachnoidal space. J Neuroimaging (2012) 1.11
In vivo monitoring of pancreatic beta-cells in a transgenic mouse model. Mol Imaging (2006) 1.11
[Effects of irrigation mode and N application rate on cotton field fertilizer N use efficiency and N losses]. Ying Yong Sheng Tai Xue Bao (2012) 1.10
Phylogenetic analysis of Enterovirus 71 circulating in Beijing, China from 2007 to 2009. PLoS One (2013) 1.09
Deconstructing Ras signaling in the thymus. Mol Cell Biol (2012) 1.09
Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. Nucleic Acids Res (2004) 1.08
Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction. BMC Cardiovasc Disord (2010) 1.07
Genome sequences of wild and domestic bactrian camels. Nat Commun (2012) 1.07
Prevalence of inherited antithrombin, protein C, and protein S deficiencies in portal vein system thrombosis and Budd-Chiari syndrome: a systematic review and meta-analysis of observational studies. J Gastroenterol Hepatol (2013) 1.07
CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer. Cancer Res (2013) 1.05
A high throughput targeted gene disruption method for Alternaria brassicicola functional genomics using linear minimal element (LME) constructs. Mol Plant Microbe Interact (2006) 1.05
MiR-23a in amplified 19p13.13 loci targets metallothionein 2A and promotes growth in gastric cancer cells. J Cell Biochem (2013) 1.05
Synchrotron photoionization measurements of combustion intermediates: photoionization efficiency and identification of C3H2 isomers. Phys Chem Chem Phys (2005) 1.04
Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem (2011) 1.04
A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro. Cancer Res (2010) 1.04