PubRank

Nicholas R J Gascoigne

Author PubWeight™ 45.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006 5.05
2 Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J 2004 3.41
3 The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 2008 2.16
4 Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol 2009 2.12
5 TCR affinity and negative regulation limit autoimmunity. Nat Med 2004 1.94
6 Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol 2005 1.85
7 CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A 2002 1.70
8 Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 2002 1.69
9 Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity 2006 1.63
10 T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem 2010 1.44
11 The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J Immunol 2002 1.38
12 Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal 2009 1.33
13 GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol 2013 1.19
14 T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med 2007 1.06
15 TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol 2003 1.05
16 Protein kinase C η is required for T cell activation and homeostatic proliferation. Sci Signal 2011 1.00
17 A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol 2005 0.99
18 Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol 2004 0.95
19 The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol 2008 0.91
20 Thymocyte stimulation by anti-TCR-beta, but not by anti-TCR-alpha, leads to induction of developmental transcription program. J Leukoc Biol 2005 0.91
21 Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. J Immunol 2003 0.89
22 Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. J Immunol Methods 2009 0.87
23 CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep 2011 0.83
24 Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med 2013 0.83
25 Tespa1: another gatekeeper for positive selection. Nat Immunol 2012 0.82
26 The role of protein kinase cη in T cell biology. Front Immunol 2012 0.80
27 Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics 2003 0.80
28 Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol 2004 0.80
29 Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells. Mol Immunol 2006 0.79
30 In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness. PLoS One 2013 0.79
31 Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers. PLoS One 2012 0.78
32 Distinct footprints of TCR engagement with highly homologous ligands. J Immunol 2004 0.77
33 Protein kinase Cη, an emerging player in T-cell biology. Cell Cycle 2012 0.76
34 CD8+ thymocyte differentiation: T cell two-step. Nat Immunol 2010 0.75
35 Too fast to die. Sci Signal 2013 0.75
36 Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells. Traffic 2006 0.75
37 Binding kinetics of superantigen with TCR and MHC class II. Methods Mol Biol 2003 0.75
38 Thymic origins of T cell receptor alloreactivity. Transplantation 2017 0.75