Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

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Published in Lancet Respir Med on September 21, 2015

Authors

Ma'en Obeidat1, Ke Hao2, Yohan Bossé3, David C Nickle4, Yunlong Nie1, Dirkje S Postma5, Michel Laviolette6, Andrew J Sandford7, Denise D Daley7, James C Hogg8, W Mark Elliott8, Nick Fishbane1, Wim Timens9, Pirro G Hysi10, Jaakko Kaprio11, James F Wilson12, Jennie Hui13, Rajesh Rawal14, Holger Schulz15, Beate Stubbe16, Caroline Hayward17, Ozren Polasek18, Marjo-Riitta Järvelin19, Jing Hua Zhao20, Deborah Jarvis21, Mika Kähönen22, Nora Franceschini23, Kari E North24, Daan W Loth25, Guy G Brusselle26, Albert Vernon Smith27, Vilmundur Gudnason27, Traci M Bartz28, Jemma B Wilk29, George T O'Connor30, Patricia A Cassano31, Wenbo Tang32, Louise V Wain33, María Soler Artigas33, Sina A Gharib34, David P Strachan35, Don D Sin7, Martin D Tobin33, Stephanie J London36, Ian P Hall37, Peter D Paré38

Author Affiliations

1: University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
2: Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
3: Department of Molecular Medicine, Laval University, Québec, QC, Canada; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, QC, Canada.
4: Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, MA, USA.
5: University of Groningen, University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, University of Groningen, Groningen, Netherlands.
6: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, QC, Canada.
7: University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
8: University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
9: Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, Groningen, Netherlands.
10: Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
11: Department of Public Health, and Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland.
12: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
13: Busselton Population Medical Research Institute, Busselton, WA, Australia; PathWest Laboratory Medicine of Western Australia, Nedlands, WA, Australia; School of Population Health and School of Pahology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia.
14: Research Unit of Molecular Epidemiology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Genetic Epidemiology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
15: Institute of Epidemiology I, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.
16: University Hospital, Department of Internal Medicine B, Greifswald, Germany.
17: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
18: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; Faculty of Medicine, University of Split, Croatia.
19: Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK; Center for Life Course Epidemiology, Faculty of Medicine, Biocenter Oulu, and Unit of Primary Care, Oulu University Hospital, University of Oulu, Oulu, Finland.
20: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge UK.
21: Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, UK; Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK.
22: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
23: Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
24: Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; University of North Carolina Center for Genome Sciences, Chapel Hill, NC, USA.
25: Departments of Epidemiology and Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands.
26: Departments of Epidemiology and Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
27: Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
28: Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.
29: Human Genetics & Computational Biomedicine, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
30: Pulmonary Center, Boston University School of Medicine, Boston, MA, USA; NHLBI Framingham Heart Study, Framingham, MA, USA.
31: Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA; Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medical College, NY, USA.
32: Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA.
33: University of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, UK; National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
34: Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
35: Population Health Research Institute, St George's, University of London, London, UK.
36: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
37: University of Nottingham Division of Respiratory Medicine, University Hospital of Nottingham, Nottingham, UK.
38: University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: peter.pare@hli.ubc.ca.

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