Published in Science on April 01, 2010
Next-generation genomics: an integrative approach. Nat Rev Genet (2010) 5.88
A census of human soluble protein complexes. Cell (2012) 3.90
Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions. J Cell Biol (2010) 3.61
The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell (2010) 3.26
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat Cell Biol (2012) 3.08
A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64
Microtubule nucleation by γ-tubulin complexes. Nat Rev Mol Cell Biol (2011) 2.49
Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. Nat Genet (2010) 2.44
Next-generation proteomics: towards an integrative view of proteome dynamics. Nat Rev Genet (2012) 2.39
Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material. Nat Cell Biol (2012) 2.19
Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14
A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell (2012) 2.07
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A (2010) 1.89
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nat Cell Biol (2011) 1.86
A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet (2011) 1.80
CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. J Cell Biol (2010) 1.80
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol (2010) 1.77
Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria. Am J Med Genet A (2011) 1.71
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Micropilot: automation of fluorescence microscopy-based imaging for systems biology. Nat Methods (2011) 1.59
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell (2012) 1.43
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. PLoS One (2011) 1.38
Deformations within moving kinetochores reveal different sites of active and passive force generation. Science (2012) 1.36
Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly. J Cell Biol (2010) 1.29
DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27
Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis. Genes Cancer (2010) 1.20
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2010) 1.18
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. Am J Hum Genet (2013) 1.16
Pericentriolar material structure and dynamics. Philos Trans R Soc Lond B Biol Sci (2014) 1.16
The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Mol Biol Cell (2010) 1.13
Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes. Nucleic Acids Res (2014) 1.12
Large-scale de novo prediction of physical protein-protein association. Mol Cell Proteomics (2011) 1.11
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J (2011) 1.11
A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat Cell Biol (2013) 1.11
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics (2011) 1.11
Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase. J Cell Biol (2013) 1.09
The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability. Plant Cell (2012) 1.08
Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of both peptide sequences and their attachment sites. Mol Cell Proteomics (2010) 1.08
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function. EMBO J (2013) 1.06
Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06
The GIP gamma-tubulin complex-associated proteins are involved in nuclear architecture in Arabidopsis thaliana. Front Plant Sci (2013) 1.05
Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell (2012) 1.05
Network analysis of GWAS data. Curr Opin Genet Dev (2013) 1.02
An extended γ-tubulin ring functions as a stable platform in microtubule nucleation. J Cell Biol (2012) 1.02
The function of spliceosome components in open mitosis. Nucleus (2010) 1.01
Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. Plant Cell (2012) 1.01
Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability. Genetics (2011) 1.01
The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol (2012) 1.01
Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. J Proteomics (2014) 1.00
Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis. J Cell Biol (2013) 1.00
Augmin plays a critical role in organizing the spindle and phragmoplast microtubule arrays in Arabidopsis. Plant Cell (2011) 1.00
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. EMBO J (2014) 0.99
A protein phosphatase 2A complex spatially controls plant cell division. Nat Commun (2013) 0.98
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort. PLoS One (2012) 0.98
Proteomics-based methods for discovery, quantification, and validation of protein-protein interactions. Anal Chem (2012) 0.98
Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB. PLoS One (2011) 0.98
On the regulation, function, and localization of the DNA-dependent ATPase PICH. Chromosoma (2012) 0.96
The Colossus of ubiquitylation: decrypting a cellular code. Mol Cell (2013) 0.96
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Front Oncol (2013) 0.96
Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling. J Signal Transduct (2012) 0.96
Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. J Proteome Res (2010) 0.96
The centrosome-Golgi apparatus nexus. Philos Trans R Soc Lond B Biol Sci (2014) 0.95
Processive ubiquitin chain formation by the anaphase-promoting complex. Semin Cell Dev Biol (2011) 0.95
Coiled-coil proteins facilitated the functional expansion of the centrosome. PLoS Comput Biol (2014) 0.95
NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'. Biomol Concepts (2013) 0.95
Building mitotic chromosomes. Curr Opin Cell Biol (2010) 0.95
Microtubule nucleation at the centrosome and beyond. Nat Cell Biol (2015) 0.94
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun (2013) 0.94
Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. BMC Genomics (2014) 0.94
Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture. Proc Natl Acad Sci U S A (2015) 0.94
SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization. Proc Natl Acad Sci U S A (2012) 0.94
Poc1A and Poc1B act together in human cells to ensure centriole integrity. J Cell Sci (2012) 0.94
Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proc Natl Acad Sci U S A (2012) 0.93
A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet (2013) 0.93
γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. EMBO J (2014) 0.93
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint. Nat Commun (2015) 0.93
Augmin-dependent microtubule nucleation at microtubule walls in the spindle. J Cell Biol (2013) 0.93
The next frontier of systems biology: higher-order and interspecies interactions. Genome Biol (2010) 0.93
Building protein-protein interaction networks with proteomics and informatics tools. J Biol Chem (2011) 0.92
Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. Mol Biol Cell (2013) 0.92
Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly. Mol Biol Cell (2013) 0.92
Genomes, proteomes, and the central dogma. Circ Cardiovasc Genet (2011) 0.91
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. EMBO J (2014) 0.91
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner. J Biol Chem (2013) 0.91
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO Rep (2016) 0.91
Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis (2015) 0.90
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. J Biol Chem (2012) 0.90
γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. PLoS One (2012) 0.90
Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS One (2012) 0.89
Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells. FASEB J (2012) 0.89
Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors. World J Gastroenterol (2013) 0.89
The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies. J Cell Biol (2015) 0.89
Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors. Proc Natl Acad Sci U S A (2014) 0.89
A Dynamical Framework for the All-or-None G1/S Transition. Cell Syst (2016) 0.88
Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2. PLoS One (2012) 0.88
The Pfam protein families database. Nucleic Acids Res (2009) 37.98
Global analysis of protein expression in yeast. Nature (2003) 34.15
Global analysis of protein localization in budding yeast. Nature (2003) 33.22
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
A new logic for DNA engineering using recombination in Escherichia coli. Nat Genet (1998) 15.27
The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol (2006) 10.76
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature (2000) 9.82
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature (2005) 9.50
Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
Genes required for mitotic spindle assembly in Drosophila S2 cells. Science (2007) 5.58
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. J Cell Biol (2008) 4.10
Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol (2007) 3.91
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol (2001) 3.86
A combined approach for the localization and tandem affinity purification of protein complexes from metazoans. Sci STKE (2005) 3.49
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc Natl Acad Sci U S A (2005) 2.59
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc Natl Acad Sci U S A (2009) 1.98
The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'? Trends Biochem Sci (2007) 1.97
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. EMBO J (2009) 1.51
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLoS Genet (2008) 1.41
Systems biology of mammalian cell division. Cell Cycle (2008) 1.04
gamma-Tubulin. Curr Biol (2002) 0.90
The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39
Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics (2010) 52.01
The Pfam protein families database. Nucleic Acids Res (2002) 51.34
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Pfam: clans, web tools and services. Nucleic Acids Res (2006) 34.83
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
The variant call format and VCFtools. Bioinformatics (2011) 25.88
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol (2005) 18.20
GeneWise and Genomewise. Genome Res (2004) 17.87
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
A large genome center's improvements to the Illumina sequencing system. Nat Methods (2008) 15.56
The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res (2009) 14.90
Ensembl 2011. Nucleic Acids Res (2010) 14.68
Ensembl 2012. Nucleic Acids Res (2011) 14.55
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates. Genome Res (2008) 12.72
Prepublication data sharing. Nature (2009) 12.24
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Population genomics of domestic and wild yeasts. Nature (2009) 11.79
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
Ensembl's 10th year. Nucleic Acids Res (2009) 10.82
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
An overview of Ensembl. Genome Res (2004) 10.35
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
QuickTree: building huge Neighbour-Joining trees of protein sequences. Bioinformatics (2002) 9.36
TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83
Dindel: accurate indel calls from short-read data. Genome Res (2010) 8.62
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
Inference of human population history from individual whole-genome sequences. Nature (2011) 8.05
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
WormBase: better software, richer content. Nucleic Acids Res (2006) 6.78
TreeFam: 2008 Update. Nucleic Acids Res (2007) 6.63
Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell (2002) 6.59
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
Efficient de novo assembly of large genomes using compressed data structures. Genome Res (2011) 6.05
Enhanced protein domain discovery by using language modeling techniques from speech recognition. Proc Natl Acad Sci U S A (2003) 6.01
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science (2009) 5.55
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell (2002) 5.36
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
WormBase: a cross-species database for comparative genomics. Nucleic Acids Res (2003) 5.28
WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol (2007) 5.17
Systems survey of endocytosis by multiparametric image analysis. Nature (2010) 5.03
High-throughput RNAi screening by time-lapse imaging of live human cells. Nat Methods (2006) 4.86
Un ménage à quatre: the molecular biology of chromosome segregation in meiosis. Cell (2003) 4.82
Dynamics and mechanics of the microtubule plus end. Nature (2003) 4.68
Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol Cell (2003) 4.67
Self-assembly of a nanoscale DNA box with a controllable lid. Nature (2009) 4.62
The quantitative proteome of a human cell line. Mol Syst Biol (2011) 4.57
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature (2005) 4.57
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell (2006) 4.52
Chromosomal cohesin forms a ring. Cell (2003) 4.38
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science (2011) 4.26
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res (2004) 4.14
Efficient construction of an assembly string graph using the FM-index. Bioinformatics (2010) 4.13
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol (2006) 4.13
Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12