Synthesis of vicinal aminoalcohols by stereoselective aza-Wacker cyclizations: access to (-)-acosamine by redox relay.

Iron(II)-catalyzed intermolecular amino-oxygenation of olefins through the N-O bond cleavage of functionalized hydroxylamines. J Am Chem Soc (2014) 0.93

The syn/anti-dichotomy in the palladium-catalyzed addition of nucleophiles to alkenes. Chemistry (2014) 0.85

Relative reactivity of alkenyl alcohols in the palladium-catalyzed redox-relay Heck reaction. Tetrahedron (2015) 0.77

In situ tether formation from amines and alcohols enabling highly selective Tsuji-Trost allylation and olefin functionalization. Chem Sci (2016) 0.75

Enantioselective Heck arylations of acyclic alkenyl alcohols using a redox-relay strategy. Science (2012) 3.04

Palladium-catalyzed ring-forming aminoacetoxylation of alkenes. J Am Chem Soc (2005) 1.82

Copper catalyzed enantioselective intramolecular aminooxygenation of alkenes. J Am Chem Soc (2008) 1.75

Construction of tetrahydrofurans by PdII/PdIV-catalyzed aminooxygenation of alkenes. Angew Chem Int Ed Engl (2007) 1.73

A Rh-Catalyzed C-H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones We thank Professors Brauman, Stack, Trost, and Wender for many helpful discussions. C.G.E. is the recipient of an NSF Predoctoral Fellowship. J.D.B. gratefully acknowledges the Camille and Henry Dreyfus Foundation for a New Faculty Award. Special thanks are extended to Merck Research Laboratories, Johnson Matthey, Professor Michael P. Doyle, and Stanford University for generous gifts and financial support. Angew Chem Int Ed Engl (2001) 1.70

Highly regioselective Pd-catalyzed intermolecular aminoacetoxylation of alkenes and evidence for cis-aminopalladation and S(N)2 C-O bond formation. J Am Chem Soc (2006) 1.69

syn-1,2-Amino alcohols via diastereoselective allylic C-H amination. J Am Chem Soc (2007) 1.47

Enantioselective redox-relay oxidative heck arylations of acyclic alkenyl alcohols using boronic acids. J Am Chem Soc (2013) 1.36

Activation of N-sulfonyl oxaziridines using copper(II) catalysts: aminohydroxylations of styrenes and 1,3-dienes. J Am Chem Soc (2008) 1.29

C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells. J Am Chem Soc (2013) 1.11

Recent developments in methodology for the direct oxyamination of olefins. Chemistry (2010) 1.03

Modular synthesis of 1,2-diamine derivatives by palladium-catalyzed aerobic oxidative cyclization of allylic sulfamides. Angew Chem Int Ed Engl (2010) 1.00

Iron(II)-catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines. J Am Chem Soc (2013) 0.98

Mechanistic studies of Wacker-type intramolecular aerobic oxidative amination of alkenes catalyzed by Pd(OAc)2/pyridine. J Org Chem (2011) 0.97

The tethered aminohydroxylation (TA) of cyclic allylic carbamates. J Am Chem Soc (2002) 0.97

Metal-free oxyaminations of alkenes using hydroxamic acids. J Am Chem Soc (2011) 0.95

Iron catalyzed asymmetric oxyamination of olefins. J Am Chem Soc (2012) 0.95

Metal-free highly regioselective aminotrifluoroacetoxylation of alkenes. J Am Chem Soc (2010) 0.91

Palladium-catalyzed intermolecular aminoacetoxylation of alkenes and the influence of PhI(OAc)2 on aminopalladation stereoselectivity. J Org Chem (2013) 0.90

Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone. J Med Chem (1975) 0.89

Catalytic asymmetric synthesis of allylic alcohols and derivatives and their applications in organic synthesis. Angew Chem Int Ed Engl (2013) 0.88

Probing the role of the mycosamine C2'-OH on the activity of amphotericin B. Org Lett (2011) 0.87

Characterization of DMSO coordination to palladium(II) in solution and insights into the aerobic oxidation catalyst, Pd(DMSO)2(TFA)2. Inorg Chem (2012) 0.86

New stereodivergent approach to 3-amino-2,3,6-trideoxysugars. Enantioselective synthesis of daunosamine, ristosamine, acosamine, and epi-daunosamine. Org Lett (2003) 0.84

Modular Synthesis of 1,2-Diamine Derivatives via Palladium-Catalyzed Aerobic Oxidative Cyclization of Allylic Sulfamides. Angew Chem Int Ed Engl (2010) 0.83

Palladium(II)-catalyzed highly regio- and diastereoselective cyclization of difunctional allylic N-tosylcarbamates. A convenient synthesis of optically active 4-vinyl-2-oxazolidinones and total synthesis of 1,4-dideoxy-1,4-imino-L-xylitol. J Org Chem (2002) 0.82

Palladium(II)-catalyzed oxidative cyclization of allylic tosylcarbamates: scope, derivatization, and mechanistic aspects. Chemistry (2012) 0.81

Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories. Angew Chem Int Ed Engl (2000) 0.79

Mimicry of antimicrobial host-defense peptides by random copolymers. J Am Chem Soc (2007) 2.12

Copper-catalyzed aerobic oxidative C-H functionalizations: trends and mechanistic insights. Angew Chem Int Ed Engl (2011) 1.79

Palladium(II)-catalyzed alkene functionalization via nucleopalladation: stereochemical pathways and enantioselective catalytic applications. Chem Rev (2011) 1.76

Highly regioselective Pd-catalyzed intermolecular aminoacetoxylation of alkenes and evidence for cis-aminopalladation and S(N)2 C-O bond formation. J Am Chem Soc (2006) 1.69

Highly practical copper(I)/TEMPO catalyst system for chemoselective aerobic oxidation of primary alcohols. J Am Chem Soc (2011) 1.64

Synthesis of pyrrolidines via palladium(II)-catalyzed aerobic oxidative carboamination of butyl vinyl ether and styrenes with allyl tosylamides. Org Lett (2006) 1.50

Copper-catalyzed aerobic oxidative amidation of terminal alkynes: efficient synthesis of ynamides. J Am Chem Soc (2008) 1.48

Palladium-catalyzed aerobic oxidative amination of alkenes: development of intra- and intermolecular aza-Wacker reactions. Inorg Chem (2007) 1.43

Carbon-nitrogen bond formation involving well-defined aryl-copper(III) complexes. J Am Chem Soc (2008) 1.40

Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones. J Am Chem Soc (2011) 1.39

Copper-catalyzed aerobic oxidative functionalization of an arene C-H bond: evidence for an aryl-copper(III) intermediate. J Am Chem Soc (2010) 1.38

Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides. J Mol Biol (2008) 1.37

Mechanistic study of copper-catalyzed aerobic oxidative coupling of arylboronic esters and methanol: insights into an organometallic oxidase reaction. J Am Chem Soc (2009) 1.34

Mechanism of Pd(OAc)2/DMSO-catalyzed aerobic alcohol oxidation: mass-transfer-limitation effects and catalyst decomposition pathways. J Am Chem Soc (2006) 1.33

Efficient intramolecular oxidative amination of olefins through direct dioxygen-coupled palladium catalysis. Angew Chem Int Ed Engl (2002) 1.32

Two-faced reactivity of alkenes: cis- versus trans-aminopalladation in aerobic Pd-catalyzed intramolecular aza-Wacker reactions. J Am Chem Soc (2007) 1.31

Allylic C-H acetoxylation with a 4,5-diazafluorenone-ligated palladium catalyst: a ligand-based strategy to achieve aerobic catalytic turnover. J Am Chem Soc (2010) 1.29

Development of Safe and Scalable Continuous-Flow Methods for Palladium-Catalyzed Aerobic Oxidation Reactions. Green Chem (2010) 1.29

Structure-activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides. J Am Chem Soc (2009) 1.26

Overcoming the "oxidant problem": strategies to use O2 as the oxidant in organometallic C-H oxidation reactions catalyzed by Pd (and Cu). Acc Chem Res (2012) 1.25

Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenols. Science (2011) 1.24

Enantioselective Pd(II)-catalyzed aerobic oxidative amidation of alkenes and insights into the role of electronic asymmetry in pyridine-oxazoline ligands. Org Lett (2011) 1.23

Aerobic oxidative amination of unactivated alkenes catalyzed by palladium. J Am Chem Soc (2005) 1.22

Ligand-modulated palladium oxidation catalysis: mechanistic insights into aerobic alcohol oxidation with the Pd(OAc)(2)/pyridine catalyst system. Org Lett (2002) 1.20

Mechanistic characterization of aerobic alcohol oxidation catalyzed by Pd(OAc)(2)/pyridine including identification of the catalyst resting state and the origin of nonlinear [catalyst] dependence. J Am Chem Soc (2004) 1.19

Chemoselective metal-free aerobic alcohol oxidation in lignin. J Am Chem Soc (2013) 1.18

Access to poly-beta-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of beta-lactams. J Am Chem Soc (2009) 1.17

Regioselective copper-catalyzed chlorination and bromination of arenes with O(2) as the oxidant. Chem Commun (Camb) (2009) 1.14

Mechanistic study of alcohol oxidation by the Pd(OAc)(2)/O(2)/DMSO catalyst system and implications for the development of improved aerobic oxidation catalysts. J Am Chem Soc (2002) 1.11

Aerobic Oxidative Coupling of o-Xylene: Discovery of 2-Fluoropyridine as a Ligand to Support Selective Pd-Catalyzed C-H Functionalization. Adv Synth Catal (2010) 1.10

Enantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands. J Am Chem Soc (2010) 1.09

Practical aerobic oxidations of alcohols and amines with homogeneous copper/TEMPO and related catalyst systems. Angew Chem Int Ed Engl (2014) 1.09

Reaction of molecular oxygen with a Pd(II)-hydride to produce a Pd(II)-hydroperoxide: experimental evidence for an HX-reductive-elimination pathway. J Am Chem Soc (2008) 1.08

Unexpected roles of molecular sieves in palladium-catalyzed aerobic alcohol oxidation. J Org Chem (2006) 1.08

Catalytic transamidation reactions compatible with tertiary amide metathesis under ambient conditions. J Am Chem Soc (2009) 1.06

"Inverse-electron-demand" ligand substitution: experimental and computational insights into olefin exchange at palladium(0). J Am Chem Soc (2004) 1.04

Mechanistic study of asymmetric oxidative biaryl coupling: evidence for self-processing of the copper catalyst to achieve control of oxidase vs oxygenase activity. J Am Chem Soc (2008) 1.03

Reversible alkene insertion into the Pd-N bond of Pd(II)-sulfonamidates and implications for catalytic amidation reactions. J Am Chem Soc (2011) 1.03

Reconciling the stereochemical course of nucleopalladation with the development of enantioselective wacker-type cyclizations. Angew Chem Int Ed Engl (2012) 1.03

Mechanism of Pd(OAc)2/pyridine catalyst reoxidation by O2: influence of labile monodentate ligands and identification of a biomimetic mechanism for O2 activation. Chemistry (2009) 1.02

Catalytic transamidation under moderate conditions. J Am Chem Soc (2003) 1.01

Highly stable redox-active molecular layers by covalent grafting to conductive diamond. J Am Chem Soc (2011) 1.01

Modular synthesis of 1,2-diamine derivatives by palladium-catalyzed aerobic oxidative cyclization of allylic sulfamides. Angew Chem Int Ed Engl (2010) 1.00

Copper(I)/ABNO-catalyzed aerobic alcohol oxidation: alleviating steric and electronic constraints of Cu/TEMPO catalyst systems. J Am Chem Soc (2013) 1.00

Direct Aerobic α, β-Dehydrogenation of Aldehydes and Ketones with a Pd(TFA)(2)/4,5-Diazafluorenone Catalyst(). Chem Sci (2011) 0.98

Mechanism of copper(I)/TEMPO-catalyzed aerobic alcohol oxidation. J Am Chem Soc (2013) 0.97

Formation of enamides via palladium(II)-catalyzed vinyl transfer from vinyl ethers to nitrogen nucleophiles. Org Lett (2004) 0.97

Mechanistic studies of Wacker-type intramolecular aerobic oxidative amination of alkenes catalyzed by Pd(OAc)2/pyridine. J Org Chem (2011) 0.97

Catalyst-controlled regioselectivity in the synthesis of branched conjugated dienes via aerobic oxidative Heck reactions. J Am Chem Soc (2012) 0.96

Catalytic metathesis of simple secondary amides. Angew Chem Int Ed Engl (2007) 0.96

Regiocontrolled aerobic oxidative coupling of indoles and benzene using Pd catalysts with 4,5-diazafluorene ligands. Chem Commun (Camb) (2011) 0.95

Characterization of peroxo and hydroperoxo intermediates in the aerobic oxidation of N-heterocyclic-carbene-coordinated palladium(0). J Am Chem Soc (2004) 0.93

Aerobic oxidative Heck/dehydrogenation reactions of cyclohexenones: efficient access to meta-substituted phenols. Angew Chem Int Ed Engl (2013) 0.93

Mechanistic studies of Wacker-type amidocyclization of alkenes catalyzed by (IMes)Pd(TFA)2(H2O): kinetic and stereochemical implications of proton transfer. J Org Chem (2012) 0.93

Pd-catalyzed Semmler-Wolff reactions for the conversion of substituted cyclohexenone oximes to primary anilines. J Am Chem Soc (2013) 0.93

PdII complexes possessing a seven-membered N-heterocyclic carbene ligand. Angew Chem Int Ed Engl (2005) 0.93

Nylon-3 copolymers that generate cell-adhesive surfaces identified by library screening. J Am Chem Soc (2009) 0.92

Mechanism of alcohol oxidation mediated by copper(II) and nitroxyl radicals. J Am Chem Soc (2014) 0.92

Observation and mechanistic study of facile C-O bond formation between a well-defined aryl-copper(III) complex and oxygen nucleophiles. Chemistry (2011) 0.91

Intramolecular Pd(II)-catalyzed aerobic oxidative amination of alkenes: synthesis of six-membered N-heterocycles. Org Lett (2012) 0.91

Biophysical mimicry of lung surfactant protein B by random nylon-3 copolymers. J Am Chem Soc (2010) 0.91

Palladium-catalyzed intermolecular aminoacetoxylation of alkenes and the influence of PhI(OAc)2 on aminopalladation stereoselectivity. J Org Chem (2013) 0.90

Aerobic intramolecular oxidative amination of alkenes catalyzed by NHC-coordinated palladium complexes. Org Lett (2006) 0.89

Dioxygen-coupled oxidative amination of styrene. J Am Chem Soc (2003) 0.89

Palladium-catalyzed oxidative amination of alkenes: improved catalyst reoxidation enables the use of alkene as the limiting reagent. Org Lett (2007) 0.89

Electrochemical water oxidation with cobalt-based electrocatalysts from pH 0-14: the thermodynamic basis for catalyst structure, stability, and activity. J Am Chem Soc (2011) 0.88

Insertion of molecular oxygen into a palladium-hydride bond: computational evidence for two nearly isoenergetic pathways. J Am Chem Soc (2007) 0.88

Copper(I)/TEMPO-catalyzed aerobic oxidation of primary alcohols to aldehydes with ambient air. Nat Protoc (2012) 0.88

Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers. Bioconjug Chem (2005) 0.88

Aerobic dehydrogenation of cyclohexanone to phenol catalyzed by Pd(TFA)2/2-dimethylaminopyridine: evidence for the role of Pd nanoparticles. J Am Chem Soc (2013) 0.88

Chemoselective organocatalytic aerobic oxidation of primary amines to secondary imines. Org Lett (2012) 0.87

Reaction of O2 with [(-)-sparteine]Pd(H)Cl: evidence for an intramolecular [H-L]+ "reductive elimination" pathway. J Am Chem Soc (2011) 0.87

C-terminal functionalization of nylon-3 polymers: effects of C-terminal groups on antibacterial and hemolytic activities. Biomacromolecules (2011) 0.87

Synthesis of Pd Complexes Bearing an Enantiomerically-Resolved Seven-Membered N-Heterocyclic Carbene Ligands and Initial Studies of their Use in Asymmetric Wacker-Type Oxidative Cyclization Reactions. Tetrahedron (2009) 0.87

Cooperative electrocatalytic alcohol oxidation with electron-proton-transfer mediators. Nature (2016) 0.86

Characterization of DMSO coordination to palladium(II) in solution and insights into the aerobic oxidation catalyst, Pd(DMSO)2(TFA)2. Inorg Chem (2012) 0.86

Steric modulation of chiral biaryl diamines via Pd-catalyzed directed C-H arylation. J Org Chem (2009) 0.85

Reaction of molecular oxygen with a PdII- hydride to produce a PdII-hydroperoxide: acid catalysis and implications for Pd-catalyzed aerobic oxidation reactions. Angew Chem Int Ed Engl (2006) 0.85

Synthesis of beta-lactams bearing functionalized side chains from a readily available precursor. Org Lett (2008) 0.85

Benzoquinone-promoted reaction of O2 with a Pd(II)-hydride. J Am Chem Soc (2011) 0.85

Brønsted base-modulated regioselectivity in the aerobic oxidative amination of styrene catalyzed by palladium. J Am Chem Soc (2005) 0.84

Cu/Nitroxyl Catalyzed Aerobic Oxidation of Primary Amines into Nitriles at Room Temperature. ACS Catal (2013) 0.84

Divergence between organometallic and single-electron-transfer mechanisms in copper(II)-mediated aerobic C-H oxidation. J Am Chem Soc (2013) 0.84

Molecular mechanism of acid-triggered aryl-halide reductive elimination in well-defined aryl-Cu(III)-halide species. Dalton Trans (2010) 0.83

Modular Synthesis of 1,2-Diamine Derivatives via Palladium-Catalyzed Aerobic Oxidative Cyclization of Allylic Sulfamides. Angew Chem Int Ed Engl (2010) 0.83

Mechanistic analysis of trans C-N reductive elimination from a square-planar macrocyclic aryl-copper(III) complex. Dalton Trans (2011) 0.83

Reaction of molecular oxygen with an NHC-coordinated Pd0 complex: computational insights and experimental implications. Angew Chem Int Ed Engl (2007) 0.83

Functionally Diverse Nylon-3 Copolymers from Readily Accessible β-Lactams. ACS Macro Lett (2012) 0.83

Pd-catalyzed aerobic oxidative coupling of arenes: evidence for transmetalation between two Pd(II)-aryl intermediates. J Am Chem Soc (2014) 0.82

Fluoride-modulated cobalt catalysts for electrochemical oxidation of water under non-alkaline conditions. ChemSusChem (2010) 0.82

Electronic structural comparison of the reactions of dioxygen and alkenes with nitrogen-chelated palladium(0). Inorg Chem (2010) 0.82

Bioinspired aerobic oxidation of secondary amines and nitrogen heterocycles with a bifunctional quinone catalyst. J Am Chem Soc (2013) 0.81

Aerobic dehydrogenation of cyclohexanone to cyclohexenone catalyzed by Pd(DMSO)2(TFA)2: evidence for ligand-controlled chemoselectivity. J Am Chem Soc (2013) 0.81

Modular o-quinone catalyst system for dehydrogenation of tetrahydroquinolines under ambient conditions. J Am Chem Soc (2014) 0.81

Insights into the spin-forbidden reaction between L2Pd0 and molecular oxygen. J Am Chem Soc (2004) 0.80

Kinetic and Spectroscopic Studies of Aerobic Copper(II)-Catalyzed Methoxylation of Arylboronic Esters and Insights into Aryl Transmetalation to Copper(II). Organometallics (2012) 0.78

Copper(II)-mediated oxidative cyclization of enamides to oxazoles. Org Biomol Chem (2012) 0.78

Synthesis and isolation of a stable, axially-chiral seven-membered N-heterocyclic carbene. Dalton Trans (2009) 0.78

Modular synthesis of alkyne-substituted ruthenium polypyridyl complexes suitable for "click" coupling. Inorg Chem (2013) 0.78

Development of an O2-sensitive fluorescence-quenching assay for the combinatorial discovery of electrocatalysts for water oxidation. Angew Chem Int Ed Engl (2012) 0.77