Published in J Ovarian Res on October 29, 2013
Functional Role of G9a Histone Methyltransferase in Cancer. Front Immunol (2015) 0.87
KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84
Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer. J Ovarian Res (2015) 0.80
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting. Oncotarget (2016) 0.78
Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells. Sci Rep (2015) 0.76
LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP. Nucleic Acids Res (2016) 0.76
Marked for death: targeting epigenetic changes in cancer. Nat Rev Drug Discov (2017) 0.76
Lysine-Specific Demethylase 1 (LSD1) Inhibitor S2101 Induces Autophagy via the AKT/mTOR Pathway in SKOV3 Ovarian Cancer Cells. Med Sci Monit (2016) 0.75
Epigenetics in cancer stem cells. Mol Cancer (2017) 0.75
Downregulation of LSD1 suppresses the proliferation, tumorigenicity and invasion of papillary thyroid carcinoma K1 cells. Oncol Lett (2016) 0.75
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98
Open source clustering software. Bioinformatics (2004) 23.17
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res (2008) 8.17
Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell (2005) 5.74
Ovarian cancer. Annu Rev Pathol (2009) 4.92
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell (2007) 4.45
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med (2012) 3.03
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res (2009) 2.65
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res (2006) 2.62
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis (2009) 2.54
T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res (2012) 2.43
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer (2011) 2.42
Deciphering and reversing tumor immune suppression. Immunity (2013) 2.24
The UCSC Cancer Genomics Browser: update 2013. Nucleic Acids Res (2012) 2.18
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature (2010) 2.01
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry (2007) 1.97
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med (2013) 1.92
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin Cancer Res (2009) 1.87
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene (2010) 1.80
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell (2013) 1.70
Lysine methylation regulates E2F1-induced cell death. Mol Cell (2010) 1.63
Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix. Am J Obstet Gynecol (1992) 1.62
LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol (2007) 1.52
Short-term primary culture of epithelial cells derived from human breast tumours. Br J Cancer (1998) 1.51
Lysine demethylases inhibitors. J Med Chem (2011) 1.48
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene (2010) 1.41
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep (2010) 1.39
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 . Biochemistry (2010) 1.36
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res (2011) 1.35
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun (2012) 1.21
LSD1 demethylates histone and non-histone proteins. Epigenetics (2009) 1.11
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol (2012) 1.09
Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr (2012) 1.07
Inhibitors of histone demethylases. Bioorg Med Chem (2011) 1.06
Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci (2011) 1.04
Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids (2011) 1.03
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin. FEBS J (2009) 1.01
Targeting protein lysine methylation and demethylation in cancers. Acta Biochim Biophys Sin (Shanghai) (2012) 0.98
Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients. World J Gastroenterol (2012) 0.97
Polyamine analogues targeting epigenetic gene regulation. Essays Biochem (2009) 0.95
The new face of ovarian cancer modeling: better prospects for detection and treatment. F1000 Med Rep (2011) 0.94
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol (2012) 0.92
Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental Platforms. Front Oncol (2013) 0.91
Androgens are not a direct requirement for the proliferation of human prostatic epithelium in vitro. Int J Cancer (1997) 0.90
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. Hum Pathol (2009) 0.90
Gene expression analyses support fallopian tube epithelium as the cell of origin of epithelial ovarian cancer. Int J Mol Sci (2013) 0.84
Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS Chem Biol (2013) 0.82