Published in Am J Respir Crit Care Med on June 01, 1998
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med (2007) 2.77
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease. Thorax (1999) 1.93
Framingham Heart Study genome-wide association: results for pulmonary function measures. BMC Med Genet (2007) 1.76
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD (2010) 1.60
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52
Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One (2014) 1.52
Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.51
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med (2012) 1.49
Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax (2010) 1.46
Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Res (2006) 1.44
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
Models of chronic obstructive pulmonary disease. Respir Res (2004) 1.42
Biological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary disease. Thorax (2005) 1.37
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med (2010) 1.36
The genetics of chronic obstructive pulmonary disease. Respir Res (2001) 1.33
Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction. Thorax (2002) 1.31
Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2009) 1.27
Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax (2004) 1.15
Smoking related COPD and facial wrinkling: is there a common susceptibility? Thorax (2006) 1.15
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2005) 1.14
Association of lung function decline with the heme oxygenase-1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), France. J Med Genet (2006) 1.12
Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2013) 1.12
High-resolution melting curve analysis of genomic and whole-genome amplified DNA. Clin Chem (2008) 1.10
Genetics and pulmonary medicine. 9. Molecular genetics of chronic obstructive pulmonary disease. Thorax (1999) 1.10
Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial. Eur Radiol (2008) 1.09
Chronic obstructive pulmonary disease in Hispanics. Am J Respir Crit Care Med (2007) 1.07
Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 1.04
Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function. Am J Respir Crit Care Med (2007) 1.01
Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma (2011) 0.99
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol (2009) 0.98
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema. Eur Respir J (2013) 0.97
Family history is a risk factor for COPD. Chest (2011) 0.96
Interaction between smoking and genetic factors in the development of chronic bronchitis. Am J Respir Crit Care Med (2007) 0.95
PRIMUS: rapid reconstruction of pedigrees from genome-wide estimates of identity by descent. Am J Hum Genet (2014) 0.95
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med (2015) 0.92
National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc (2008) 0.92
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.92
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest (2008) 0.91
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genet (2014) 0.91
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics (2013) 0.89
Genes and chronic obstructive pulmonary disease. Med Clin North Am (2012) 0.88
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med (2008) 0.88
SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. Am J Respir Crit Care Med (2011) 0.88
Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 0.87
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med (2016) 0.87
Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency. Int J Chron Obstruct Pulmon Dis (2006) 0.86
alpha1-Antitrypsin deficiency . 6: new and emerging treatments for alpha1-antitrypsin deficiency. Thorax (2004) 0.86
Genetic epidemiology of cigarette smoke-induced lung disease. Proc Am Thorac Soc (2012) 0.85
Folliculin mutations are not associated with severe COPD. BMC Med Genet (2008) 0.85
Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium. Clin Transl Sci (2009) 0.84
Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS One (2014) 0.83
Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 0.83
Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2014) 0.82
Genetic and environmental influence on lung function impairment in Swedish twins. Respir Res (2010) 0.82
Pulmonary function and emphysema in Williams-Beuren syndrome. Am J Med Genet A (2010) 0.81
Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease. Environ Health Perspect (2000) 0.81
Gene polymorphisms and chronic obstructive pulmonary disease. J Cell Mol Med (2013) 0.81
Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health (2013) 0.81
Transcriptomic Analysis of Lung Tissue from Cigarette Smoke Induced Emphysema Murine Models and Human COPD Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol (2017) 0.80
Microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease: A comprehensive meta-analysis. Oncol Lett (2012) 0.80
Extracellular superoxide dismutase and risk of COPD. COPD (2009) 0.80
Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A (2016) 0.80
Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD. Respir Res (2014) 0.79
Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach. Biostatistics (2011) 0.79
Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. Eur Respir J (2014) 0.79
Susceptibility to COPD: differential proteomic profiling after acute smoking. PLoS One (2014) 0.78
Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees. Am J Hum Genet (2016) 0.77
Lower corticosteroid skin blanching response is associated with severe COPD. PLoS One (2014) 0.77
Combining disease models to test for gene-environment interaction in nuclear families. Biometrics (2011) 0.76
Filtering data from the collaborative initial glaucoma treatment study for improved identification of glaucoma progression. BMC Med Inform Decis Mak (2013) 0.75
Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol (2017) 0.75
Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia. PLoS One (2015) 0.75
"What are my chances of developing COPD if one of my parents has the disease?" A systematic review and meta-analysis of prevalence of co-occurrence of COPD diagnosis in parents and offspring. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Association between TNF-α -308 G/A polymorphism and COPD susceptibility: a meta-analysis update. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Telomerase and the Genetics of Emphysema Susceptibility. Implications for Pathogenesis Paradigms and Patient Care. Ann Am Thorac Soc (2016) 0.75
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies. BMC Pulm Med (2017) 0.75
Body height as risk factor for emphysema in COPD. Sci Rep (2016) 0.75
Concordance of genotypes in pre- and post-lung transplantation DNA samples. Am J Respir Cell Mol Biol (2005) 0.75
Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep (2017) 0.75
Family-Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis. Genet Epidemiol (2016) 0.75
A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India. Lung India (2015) 0.75
Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil. J Bras Pneumol (2016) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics (2017) 0.75
An association between air pollution and mortality in six U.S. cities. N Engl J Med (1993) 38.84
Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol (1985) 26.13
Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med (1995) 15.80
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
Observations on recent increase in mortality from asthma. Br Med J (1968) 14.82
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med (1995) 11.08
Body weight and mortality among women. N Engl J Med (1995) 11.04
Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol (1989) 10.98
Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol (1986) 10.84
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet (1998) 10.11
Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J (2008) 10.08
Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol (1994) 9.90
Aspirin and the risk of colorectal cancer in women. N Engl J Med (1995) 9.59
Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med (1990) 8.98
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med (1991) 8.66
Prospective study of alcohol consumption and risk of coronary disease in men. Lancet (1991) 8.64
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Test of the National Death Index. Am J Epidemiol (1984) 8.46
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet (1991) 7.87
A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol (1993) 7.73
Sponsorship, authorship, and accountability. Lancet (2001) 7.10
Plasma organochlorine levels and the risk of breast cancer. N Engl J Med (1997) 7.02
The concept of disease. Br Med J (1979) 6.51
The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med (2001) 6.37
Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med (1999) 6.21
Sponsorship, authorship, and accountability. N Engl J Med (2001) 6.20
Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med (1999) 6.17
A prospective study of family history and the risk of colorectal cancer. N Engl J Med (1994) 6.12
A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med (1990) 6.06
Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J Infect Dis (1989) 5.87
Sponsorship, authorship and accountability. CMAJ (2001) 5.86
The circumstances preceding death from asthma in young people in 1968 to 1969. Br J Dis Chest (1971) 5.53
Vitamin E consumption and the risk of coronary disease in women. N Engl J Med (1993) 5.39
Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst (2001) 5.33
The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol (1988) 5.32
Tubal ligation, hysterectomy, and risk of ovarian cancer. A prospective study. JAMA (1993) 5.31
Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med (1993) 5.19
A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med (2000) 5.17
Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr (1999) 5.12
Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered (2003) 5.06
Birthweight as a risk factor for breast cancer. Lancet (1996) 5.05
Intake of trans fatty acids and risk of coronary heart disease among women. Lancet (1993) 5.00
Postmenopausal hormone therapy and mortality. N Engl J Med (1997) 4.96
The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis (1983) 4.90
Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol (2000) 4.83
Dual effects of weight and weight gain on breast cancer risk. JAMA (1997) 4.81
Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA (1992) 4.80
Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight range. JAMA (1995) 4.78
Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst (1998) 4.74
Menopause and the risk of coronary heart disease in women. N Engl J Med (1987) 4.70
Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA (1998) 4.65
Weight as a risk factor for clinical diabetes in women. Am J Epidemiol (1990) 4.64
A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med (1999) 4.61
A prospective study of passive smoking and coronary heart disease. Circulation (1997) 4.51
A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA (1997) 4.50
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ (1997) 4.49
Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med (1999) 4.49
Effects of inhalable particles on respiratory health of children. Am Rev Respir Dis (1989) 4.49
Cigarette smoking, relative weight, and menopause. Am J Epidemiol (1983) 4.46
Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA (1999) 4.43
Smoking cessation and decreased risk of stroke in women. JAMA (1993) 4.36
Alcohol consumption and mortality among women. N Engl J Med (1995) 4.22
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science (1996) 4.22
The perception of breathlessness in asthma. Am Rev Respir Dis (1982) 4.17
Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Ann Intern Med (1997) 4.16
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest (2000) 4.16
A retrospective cohort study of vasectomy and prostate cancer in US men. JAMA (1993) 4.12
Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses' Health Study. Am J Epidemiol (2000) 3.94
Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr (1999) 3.91
Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst (1995) 3.88
The relationship of bone and blood lead to hypertension. The Normative Aging Study. JAMA (1996) 3.87
A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med (1991) 3.85
Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest (2000) 3.84
Epidemic of obesity in UK children. Lancet (1999) 3.80
A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA (1996) 3.79
Reproducibility and validity of self-reported menopausal status in a prospective cohort study. Am J Epidemiol (1987) 3.77
Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study. Am J Epidemiol (1997) 3.75