Published in Epigenetics Chromatin on October 16, 2013
Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation. Sci Rep (2015) 1.03
Expression and functionality of histone H2A variants in cancer. Oncotarget (2014) 0.95
Integration of mRNA expression profile, copy number alterations, and microRNA expression levels in breast cancer to improve grade definition. PLoS One (2014) 0.90
Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules. ACS Chem Biol (2015) 0.86
The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin. J Cancer Res Clin Oncol (2015) 0.85
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J (2017) 0.85
MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev (2016) 0.82
Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome. Oncotarget (2015) 0.82
Analysis of gene expression in cyclooxygenase-2-overexpressed human osteosarcoma cell lines. Genomics Inform (2014) 0.78
BPTF Associated with EMT Indicates Negative Prognosis in Patients with Hepatocellular Carcinoma. Dig Dis Sci (2014) 0.77
Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations. Expert Rev Proteomics (2015) 0.77
Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming. Stem Cells Int (2015) 0.75
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Chromatin modifications and their function. Cell (2007) 55.98
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Integrative genomics viewer. Nat Biotechnol (2011) 42.83
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Nucleosome organization in the Drosophila genome. Nature (2008) 8.65
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell (1998) 7.58
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Cell (2005) 5.36
Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. PLoS Biol (2005) 4.48
Histone variants--ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol (2010) 4.45
Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature (2008) 4.20
Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. Nat Struct Biol (2000) 4.05
Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res (2008) 4.03
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science (2013) 2.67
p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev (2007) 2.21
The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesis. PLoS Genet (2008) 2.14
H2A.Z: view from the top. Structure (2008) 2.07
Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression. Mol Syst Biol (2008) 1.89
Comparative analysis of H2A.Z nucleosome organization in the human and yeast genomes. Genome Res (2009) 1.74
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends Mol Med (2007) 1.59
H2A.Z nucleosomes enriched over active genes are homotypic. Nat Struct Mol Biol (2010) 1.41
Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res (2011) 1.39
EpiChIP: gene-by-gene quantification of epigenetic modification levels. Nucleic Acids Res (2010) 1.23
Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A. Nucleic Acids Res (2009) 1.12
H2A.Z overexpression promotes cellular proliferation of breast cancer cells. Cell Cycle (2010) 1.08
Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. PLoS Genet (2012) 1.07
Histone variants and complexes involved in their exchange. Subcell Biochem (2007) 1.03
A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation. PLoS Genet (2012) 1.02
ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes Dev (2012) 1.02
Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol (2011) 0.94
Analysis and simulation of gene expression profiles in pure and mixed cell populations. Phys Biol (2011) 0.93
Cell-penetrating H4 tail peptides potentiate p53-mediated transactivation via inhibition of G9a and HDAC1. Oncogene (2012) 0.84
H2A.Z sets the stage in ESCs. Cell Stem Cell (2013) 0.79
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73
Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70
Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res (2011) 4.84
Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn (2006) 4.68
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe (2009) 3.95
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol (2002) 3.79
Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature (2007) 3.71
Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun (2008) 3.06
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell (2003) 2.97
Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol (2011) 2.81
30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol (2008) 2.62
A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J (2008) 2.46
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes. J Natl Cancer Inst (2010) 2.38
Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res (2013) 2.19
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev (2008) 2.12
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila) (2008) 2.04
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell (2013) 2.04
Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol (2012) 2.02
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe (2012) 1.99
Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res (2006) 1.99
ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase. EMBO Rep (2007) 1.99
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
A comparison of cluster analysis methods using DNA methylation data. Bioinformatics (2004) 1.94
Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One (2009) 1.90
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circ Res (2004) 1.81
Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog (2010) 1.79
Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75
DNA hypomethylation and ovarian cancer biology. Cancer Res (2004) 1.75
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res (2002) 1.73
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell (2013) 1.68
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription. J Biol Chem (2008) 1.66
Epidermal growth factor receptor as a predictor of tumor downstaging in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys (2006) 1.65
DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines. PLoS One (2010) 1.65
Sensitive detection of DNA methylation. Ann N Y Acad Sci (2003) 1.65
Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia. Ann Surg Oncol (2010) 1.63
Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbiol (2010) 1.62
Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res (2011) 1.62
Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology (2007) 1.56
Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One (2007) 1.55
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res (2006) 1.52
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. Eur Arch Otorhinolaryngol (2013) 1.52
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells (2010) 1.50
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res (2010) 1.47
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Discovery of multi-dimensional modules by integrative analysis of cancer genomic data. Nucleic Acids Res (2012) 1.46
MethyLight. Methods Mol Biol (2009) 1.45
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget (2013) 1.44
Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area. J Hum Genet (2011) 1.43
Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. J Clin Endocrinol Metab (2006) 1.43
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res (2008) 1.42
An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst (2013) 1.42
Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci U S A (2002) 1.41
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nat Med (2006) 1.40
SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem (2001) 1.40
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev (2002) 1.38
Distinct methylation profiles of glioma subtypes. Int J Cancer (2003) 1.38
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet (2005) 1.35
DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest (2007) 1.34
Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 1.32
Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol (2011) 1.29
Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol (2006) 1.29
Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm. Am J Pathol (2009) 1.28
Central cervical nodal metastasis from papillary thyroid microcarcinoma: pattern and factors predictive of nodal metastasis. Ann Surg Oncol (2008) 1.27
Lateral cervical lymph node metastases from papillary thyroid carcinoma: pattern of nodal metastases and optimal strategy for neck dissection. Ann Surg Oncol (2008) 1.27