Published in Nat Commun on January 01, 2013
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes. J Am Soc Nephrol (2016) 1.40
The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme. PLoS Biol (2014) 0.87
SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep (2015) 0.82
Human genetics of nephrotic syndrome and the quest for precision medicine. Curr Opin Nephrol Hypertens (2016) 0.76
RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal. BMC Nephrol (2016) 0.75
RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways. Sci Rep (2016) 0.75
Adrenomedullin ameliorates podocyte injury induced by puromycin aminonucleoside in vitro and in vivo through modulation of Rho GTPases. Int Urol Nephrol (2017) 0.75
Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes. J Am Soc Nephrol (2017) 0.75
Podocytes and the quest for precision medicines for kidney diseases. Pflugers Arch (2017) 0.75
Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol (2005) 16.77
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res (1997) 6.24
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med (2008) 5.01
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol (1997) 4.43
Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol (2007) 4.31
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature (2009) 3.83
Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol (2006) 3.31
Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest (2006) 3.23
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem (2001) 2.85
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem Biol (2009) 2.57
Cell biology and pathology of podocytes. Annu Rev Physiol (2011) 2.42
The Cbl family proteins: ring leaders in regulation of cell signaling. J Cell Physiol (2006) 2.40
Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest (2005) 2.39
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol (1997) 2.24
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem (1999) 2.13
The Nck family of adapter proteins: regulators of actin cytoskeleton. Cell Signal (2002) 2.13
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84
Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest (2006) 1.66
Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem (1994) 1.42
Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow. J Cell Biol (2012) 1.42
Preferred in vivo ubiquitination sites. Bioinformatics (2004) 1.36
Nck adapter proteins: functional versatility in T cells. Cell Commun Signal (2009) 1.32
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol (2005) 1.23
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. J Biol Chem (1998) 1.09
The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. Proc Natl Acad Sci U S A (2005) 1.08
VEGF treatment induces signaling pathways that regulate both actin polymerization and depolymerization. Angiogenesis (2005) 1.06
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem (2008) 0.97
Requirement of multiple SH3 domains of Nck for ligand binding. Cell Signal (1999) 0.89
Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor. Oncogene (2001) 0.88
Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization. EMBO J (2011) 0.88
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. J Biol Chem (2011) 0.83
Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development. J Biol Chem (2000) 0.78
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol (2002) 6.48
Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med (2013) 5.62
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med (2008) 5.01
Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest (2004) 4.65
Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol (2007) 4.31
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet (2007) 3.47
Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol (2006) 3.31
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74
Cell biology and pathology of podocytes. Annu Rev Physiol (2011) 2.42
Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest (2005) 2.39
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol (2006) 2.32
Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int (2004) 2.21
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest (2011) 2.21
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem (2004) 2.10
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A (2003) 1.79
Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest (2013) 1.76
A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem (2004) 1.70
Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70
Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J (2010) 1.67
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest (2006) 1.66
Metabolite profiling identifies markers of uremia. J Am Soc Nephrol (2010) 1.63
TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes. J Am Soc Nephrol (2005) 1.61
The role of podocytes in glomerular pathobiology. Clin Exp Nephrol (2003) 1.57
Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis. Kidney Int (2011) 1.57
In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies. Am J Pathol (2005) 1.54
Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum (2005) 1.41
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. Am J Physiol Renal Physiol (2006) 1.38
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol (2002) 1.34
Podocyte biology and the emerging understanding of podocyte diseases. Am J Nephrol (2003) 1.31
The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. Am J Physiol Renal Physiol (2008) 1.31
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol (2007) 1.30
Danger signaling by glomerular podocytes defines a novel function of inducible B7-1 in the pathogenesis of nephrotic syndrome. J Am Soc Nephrol (2004) 1.27
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. J Biol Chem (2002) 1.26
Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. Pediatr Nephrol (2003) 1.25
Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int (2002) 1.24
A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J Biol Chem (2004) 1.23
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol (2005) 1.23
Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. Proc Natl Acad Sci U S A (2007) 1.16
Inhibitory smads and tgf-Beta signaling in glomerular cells. J Am Soc Nephrol (2002) 1.15
Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell (2003) 1.15
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease. Proc Natl Acad Sci U S A (2008) 1.13
Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol (2011) 1.11
Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention. Am J Pathol (2006) 1.10
Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney. Am J Physiol Renal Physiol (2003) 1.08
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids. Am J Physiol Renal Physiol (2010) 1.07
A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol (2002) 1.06
Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. J Am Soc Nephrol (2005) 1.06
Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol (2012) 1.05
Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. Oncogene (2003) 1.05
Role of nephrin in renal disease including diabetic nephropathy. Semin Nephrol (2002) 1.03
Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4. Biophys J (2008) 1.02
Glomerular endothelial fenestrae in vivo are not formed from caveolae. J Am Soc Nephrol (2002) 1.01
Calcium regulates podocyte actin dynamics. Semin Nephrol (2012) 0.98
Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes. Curr Diabetes Rev (2011) 0.94
Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling. J Biol Chem (2013) 0.94
Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol (2007) 0.93
Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol (2005) 0.93
Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria. Curr Opin Nephrol Hypertens (2009) 0.92
Differential expression of d-type cyclins in podocytes in vitro and in vivo. Am J Pathol (2004) 0.92
Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Am J Respir Crit Care Med (2007) 0.92
Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. J Am Soc Nephrol (2003) 0.92
Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing. Am J Kidney Dis (2011) 0.91
Dual effects of RAS blockade on blood pressure and podocyte function. Curr Hypertens Rep (2007) 0.88
Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease. Curr Opin Nephrol Hypertens (2015) 0.88
Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization. EMBO J (2011) 0.88
Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells. J Biol Chem (2012) 0.87
Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes (2009) 0.87
Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria. J Pathol (2013) 0.85
IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis. J Am Soc Nephrol (2003) 0.85
Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. Am J Pathol (2013) 0.84
Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus. J Neurosci (2013) 0.84
mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity. J Clin Invest (2014) 0.83
Differentiation-induced cultured podocytes express endocytically active megalin, a heymann nephritis antigen. Nephron Exp Nephrol (2004) 0.81
Novel concepts in understanding and management of glomerular proteinuria. Nephrol Dial Transplant (2002) 0.80
Plasticity of synaptopodin and the spine apparatus organelle in the rat fascia dentata following entorhinal cortex lesion. J Comp Neurol (2006) 0.80
Urinary podocytes: lost and found alive. Kidney Int (2003) 0.80
Expression and regulation of adrenomedullin in renal glomerular podocytes. Biochem Biophys Res Commun (2005) 0.79
Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med (2014) 0.79
Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1β secretion in the peripheral blood. Transplantation (2014) 0.79
Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2. Am J Physiol Renal Physiol (2013) 0.78
Short-term ischemia usually used for ischemic preconditioning causes loss of dendritic integrity after long-term survival in the gerbil hippocampus. Brain Res (2006) 0.78
SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol (2012) 0.77
Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons. J Comp Neurol (2002) 0.76
Case 4-2013: A man with acute flank pain. N Engl J Med (2013) 0.75