Published in Med Phys on December 01, 2013
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound. Neuropharmacology (2016) 0.79
Chirp- and random-based coded ultrasonic excitation for localized blood-brain barrier opening. Phys Med Biol (2015) 0.76
Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy. Phys Med Biol (2016) 0.76
A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping. Phys Med Biol (2016) 0.75
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology (2001) 6.30
Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med (2004) 5.32
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A (2006) 3.70
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer (2007) 3.21
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage (2005) 3.17
Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery (2010) 3.15
A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med (2013) 2.82
High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol (2009) 2.68
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res (2012) 2.60
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol (2013) 2.37
Acoustical properties of the human skull. J Acoust Soc Am (1978) 2.33
Transcranial pulsed ultrasound stimulates intact brain circuits. Neuron (2010) 2.33
Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke (2005) 2.24
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol (2008) 2.17
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound Med Biol (1998) 1.93
High power transcranial beam steering for ultrasonic brain therapy. Phys Med Biol (2003) 1.87
Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol (2010) 1.86
Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain. Proc Natl Acad Sci U S A (2010) 1.84
A theoretical assessment of the relative performance of spherical phased arrays for ultrasound surgery. IEEE Trans Ultrason Ferroelectr Freq Control (2000) 1.59
Longitudinal and shear mode ultrasound propagation in human skull bone. Ultrasound Med Biol (2006) 1.46
Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain. Neurosurg Focus (2012) 1.40
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. PLoS One (2011) 1.35
Simulation of intracranial acoustic fields in clinical trials of sonothrombolysis. Ultrasound Med Biol (2009) 1.34
Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model. J Vasc Interv Radiol (2010) 1.30
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol (2012) 1.29
Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke. Stroke (2011) 1.28
Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. Am Heart J (1996) 1.21
Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls. Phys Med Biol (2010) 1.19
3D models of blood flow in the cerebral vasculature. J Biomech (2005) 1.13
In vivo transcranial brain surgery with an ultrasonic time reversal mirror. J Neurosurg (2007) 1.13
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Hum Gene Ther (2012) 1.12
Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment. Neuro Oncol (2010) 1.11
Sparse 2-D array design for real time rectilinear volumetric imaging. IEEE Trans Ultrason Ferroelectr Freq Control (2000) 1.10
In vitro and in vivo high-intensity focused ultrasound thrombolysis. Invest Radiol (2012) 1.08
Propagation and backpropagation for ultrasonic wavefront design. IEEE Trans Ultrason Ferroelectr Freq Control (1997) 1.04
Surface interpolation from sparse cross sections using region correspondence. IEEE Trans Med Imaging (2000) 1.03
A unified model for the speed of sound in cranial bone based on genetic algorithm optimization. Phys Med Biol (2002) 1.02
The role of nonlinear ultrasound propagation during hyperthermia treatments. Med Phys (1992) 1.02
High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. PLoS One (2012) 1.01
In vitro effects of ultrasound with different energies on the conduction properties of neural tissue. Ultrasonics (2004) 1.00
Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and simulation study. IEEE Trans Biomed Eng (2011) 0.99
Sonothrombolysis: an emerging modality for the management of stroke. Neurosurgery (2009) 0.91
The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study. Phys Med Biol (2012) 0.86
Effects of nonlinear ultrasound propagation on high intensity brain therapy. Med Phys (2011) 0.84
Effective gene transfer into central nervous system following ultrasound-microbubbles-induced opening of the blood-brain barrier. Ultrasound Med Biol (2012) 0.83
Targeting accuracy of transcranial magnetic resonance-guided high-intensity focused ultrasound brain therapy: a fresh cadaver model. J Neurosurg (2013) 0.82
Cavitation-based third ventriculostomy using MRI-guided focused ultrasound. J Neurosurg (2013) 0.82
The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study. Phys Med Biol (2011) 0.81
Non-invasive ultrasonic surgery of the brain in non-human primates. J Acoust Soc Am (2013) 0.80
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A (2006) 3.70
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer (2007) 3.21
Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery (2010) 3.15
MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology (2003) 3.07
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol (2004) 2.76
Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol (2007) 2.66
MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound Med Biol (2005) 2.57
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound Med Biol (2008) 2.47
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol (2013) 2.37
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun (2005) 2.28
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol (2008) 2.17
Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound Med Biol (2003) 2.07
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol (2008) 2.03
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PLoS One (2010) 2.03
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One (2008) 1.95
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols. Radiology (2007) 1.90
Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation. Radiology (2006) 1.89
Localized harmonic motion imaging: theory, simulations and experiments. Ultrasound Med Biol (2003) 1.74
Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology (2006) 1.71
Magnetic resonance image-guided focused ultrasound surgery. Cancer J (2002) 1.70
Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology (2014) 1.68
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. Radiology (2012) 1.64
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. Ultrasound Med Biol (2007) 1.63
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cereb Blood Flow Metab (2006) 1.60
Overview of therapeutic ultrasound applications and safety considerations. J Ultrasound Med (2012) 1.54
MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin N Am (2005) 1.52
Focused ultrasound surgery in oncology: overview and principles. Radiology (2011) 1.51
Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Ultrasound Med Biol (2006) 1.49
MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain. Magn Reson Med (2004) 1.47
Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics (2008) 1.42
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success. Radiology (2008) 1.37
The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Phys Med Biol (2010) 1.37
An MRI-compatible system for focused ultrasound experiments in small animal models. Med Phys (2009) 1.36
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. PLoS One (2011) 1.35
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol (2012) 1.29
A numerical study of transcranial focused ultrasound beam propagation at low frequency. Phys Med Biol (2005) 1.27
A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound. Biochem Biophys Res Commun (2005) 1.21
A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy. J Ultrasound Med (2005) 1.21
Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Exp Neurol (2013) 1.19
Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls. Phys Med Biol (2010) 1.19
Cavitation threshold of microbubbles in gel tunnels by focused ultrasound. Ultrasound Med Biol (2007) 1.18
Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation. Biochem Biophys Res Commun (2007) 1.18
Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag (2006) 1.14
Localised drug release using MRI-controlled focused ultrasound hyperthermia. Int J Hyperthermia (2010) 1.14
Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. ACS Chem Neurosci (2010) 1.13
Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate. Ultrasound Med Biol (2011) 1.13
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Hum Gene Ther (2012) 1.12
Micro-receiver guided transcranial beam steering. IEEE Trans Ultrason Ferroelectr Freq Control (2002) 1.11
Focused ultrasound delivers targeted immune cells to metastatic brain tumors. Cancer Res (2013) 1.10
Correlation of ultrasound phase with physical skull properties. Ultrasound Med Biol (2002) 1.10
In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy. Phys Med Biol (2010) 1.09
In vitro and in vivo high-intensity focused ultrasound thrombolysis. Invest Radiol (2012) 1.08
Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies. Ultrasound Med Biol (2011) 1.05
Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison. Ultrasound Med Biol (2006) 1.05
Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study. Phys Med Biol (2002) 1.04
Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening. J Cereb Blood Flow Metab (2011) 1.04
Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE Trans Ultrason Ferroelectr Freq Control (2005) 1.04
Focused ultrasound effects on nerve action potential in vitro. Ultrasound Med Biol (2009) 1.03
A unified model for the speed of sound in cranial bone based on genetic algorithm optimization. Phys Med Biol (2002) 1.02
In vivo monitoring of focused ultrasound surgery using local harmonic motion. Ultrasound Med Biol (2008) 1.02
Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound. Ultrasound Med Biol (2010) 1.02
High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. PLoS One (2012) 1.01
Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids. J Magn Reson Imaging (2008) 1.00
Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and simulation study. IEEE Trans Biomed Eng (2011) 0.99
Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery. IEEE Trans Biomed Eng (2004) 0.99
A super-resolution ultrasound method for brain vascular mapping. Med Phys (2013) 0.99
Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy. IEEE Trans Biomed Eng (2009) 0.98
Apoptosis signals in lymphoblasts induced by focused ultrasound. FASEB J (2004) 0.98
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC Neurol (2010) 0.97
A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy. IEEE Trans Biomed Eng (2010) 0.97
Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound. Gastroenterology (2004) 0.97
Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney. Radiology (2004) 0.97
Temperature change near microbubbles within a capillary network during focused ultrasound. Phys Med Biol (2010) 0.97
MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids. J Magn Reson Imaging (2009) 0.96
Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment. Phys Med Biol (2011) 0.96
Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS Chem Neurosci (2013) 0.95
Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study. Phys Med Biol (2013) 0.95
MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs. Magn Reson Med (2004) 0.95
Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia. Radiat Res (2006) 0.94
Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine (2012) 0.94
Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles. PLoS One (2012) 0.94
Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array. IEEE Trans Biomed Eng (2014) 0.94
Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression. J Control Release (2012) 0.94
Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound. Pharm Res (2005) 0.94
Ultrasound enhanced drug delivery to the brain and central nervous system. Int J Hyperthermia (2012) 0.93
Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study. Ultrason Imaging (2006) 0.92
Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. J Control Release (2013) 0.92
Focal beam distortion and treatment planning in abdominal focused ultrasound surgery. Med Phys (2005) 0.92
Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurg Focus (2012) 0.91
Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours. Int J Hyperthermia (2015) 0.91
Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia. Int J Hyperthermia (2012) 0.91
Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors. Neuroimaging Clin N Am (2002) 0.90
Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging. IEEE Trans Med Imaging (2007) 0.90
Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer (2010) 0.89
Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles. Int J Cancer (2013) 0.89
Numerical simulations of clinical focused ultrasound functional neurosurgery. Phys Med Biol (2014) 0.89
A new ultrasound method for determining the acoustic phase shifts caused by the skull bone. Ultrasound Med Biol (2005) 0.89
Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study. Phys Med Biol (2007) 0.88
Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery. Radiology (2012) 0.87
Intracranial applications of magnetic resonance-guided focused ultrasound. Neurotherapeutics (2014) 0.87