PubRank

David A Hafler

Author PubWeight™ 317.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007 17.06
2 A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 2006 15.63
3 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011 13.23
4 Methods for high-density admixture mapping of disease genes. Am J Hum Genet 2004 12.02
5 A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet 2004 10.87
6 Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004 8.98
7 Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007 8.74
8 FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010 8.73
9 Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009 7.16
10 IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008 7.00
11 A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet 2005 5.02
12 Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A 2009 4.91
13 Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013 4.57
14 Induction and molecular signature of pathogenic TH17 cells. Nat Immunol 2012 4.43
15 Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet 2011 4.42
16 MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 2006 4.06
17 Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 2007 3.92
18 De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet 2009 3.86
19 Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 2007 3.70
20 Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005 3.62
21 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011 3.52
22 Human CD4+CD25+ regulatory T cells. Semin Immunol 2004 3.13
23 Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009 3.04
24 IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009 3.04
25 Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 2009 2.95
26 Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014 2.77
27 Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med 2007 2.64
28 Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 2014 2.63
29 Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol 2002 2.61
30 Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol 2005 2.60
31 Human regulatory T cells and their role in autoimmune disease. Immunol Rev 2006 2.56
32 A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 2005 2.50
33 Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med 2006 2.43
34 Multiple sclerosis. J Clin Invest 2012 2.41
35 Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol 2009 2.41
36 The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A 2009 2.38
37 Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009 2.31
38 IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009 2.30
39 Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med 2011 2.14
40 Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol 2008 2.03
41 Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A 2011 2.00
42 An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 2004 2.00
43 TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol 2009 2.00
44 A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol 2007 1.99
45 T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol 2004 1.97
46 Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip 2010 1.97
47 GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest 2002 1.95
48 Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest 2006 1.91
49 Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet 2010 1.89
50 Fingolimod for multiple sclerosis. N Engl J Med 2012 1.85
51 Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol 2009 1.83
52 Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep 2014 1.79
53 PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol 2004 1.78
54 Specific peripheral B cell tolerance defects in patients with multiple sclerosis. J Clin Invest 2013 1.76
55 Suppressor T cells in human diseases. J Exp Med 2004 1.73
56 Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain 2011 1.61
57 TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 2008 1.58
58 Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet 2013 1.55
59 Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol 2009 1.55
60 Human regulatory T cells and autoimmunity. Eur J Immunol 2008 1.54
61 Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol 2009 1.50
62 Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology 2013 1.46
63 Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol 2008 1.45
64 Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest 2015 1.43
65 Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol 2005 1.43
66 The TIGIT/CD226 axis regulates human T cell function. J Immunol 2012 1.43
67 Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proc Natl Acad Sci U S A 2007 1.42
68 TGF-beta induces IL-9 production from human Th17 cells. J Immunol 2010 1.40
69 Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain 2008 1.34
70 Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet 2004 1.29
71 The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol 2013 1.29
72 An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med 2012 1.29
73 CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp 2003 1.28
74 Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol 2011 1.27
75 Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol 2013 1.25
76 Microbial reprogramming inhibits Western diet-associated obesity. PLoS One 2013 1.21
77 Immune-mediated disease genetics: the shared basis of pathogenesis. Trends Immunol 2012 1.20
78 Multiple sclerosis and regulatory T cells. J Clin Immunol 2008 1.17
79 Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol 2003 1.16
80 Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet 2010 1.16
81 Regulatory T cells in the central nervous system. Immunol Rev 2012 1.12
82 Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. J Neuroimmunol 2010 1.09
83 A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol 2007 1.06
84 Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med 2011 1.06
85 High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol 2005 1.04
86 Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation 2008 1.03
87 On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem 2010 1.02
88 Autoimmunity risk alleles in costimulation pathways. Immunol Rev 2009 1.01
89 CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet 2010 1.01
90 Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol 2008 1.01
91 The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J Immunol 2011 1.01
92 Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol 2011 1.00
93 Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. Eur J Hum Genet 2006 1.00
94 Regulatory T cells in autoimmune neuroinflammation. Immunol Rev 2014 1.00
95 The developing mosaic of autoimmune disease risk. Nat Genet 2008 1.00
96 Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet 2010 0.99
97 A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One 2010 0.98
98 RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. J Immunol 2009 0.98
99 Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet 2009 0.96
100 Genetic basis of autoimmunity. J Clin Invest 2015 0.96
101 CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol 2011 0.96
102 Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosens Bioelectron 2010 0.95
103 Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. J Biol Chem 2003 0.95
104 Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Hum Mol Genet 2011 0.95
105 Human regulatory T cells in autoimmune diseases. Curr Opin Immunol 2010 0.95
106 New therapeutic approaches for multiple sclerosis. Annu Rev Med 2007 0.95
107 PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun 2013 0.94
108 Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol 2004 0.93
109 The purification and functional analysis of human CD4+CD25high regulatory T cells. Curr Protoc Immunol 2006 0.93
110 The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol 2013 0.93
111 Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet 2010 0.93
112 Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol 2010 0.93
113 Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol 2005 0.91
114 Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013 0.91
115 Abnormal Tr1 differentiation in multiple sclerosis. J Neuroimmunol 2007 0.91
116 CTLA4 is associated with susceptibility to multiple sclerosis. J Neuroimmunol 2003 0.90
117 Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol 2005 0.89
118 Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol 2008 0.88
119 Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol 2009 0.88
120 Gene expression profiling in MS: what is the clinical relevance? Lancet Neurol 2004 0.87
121 Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. J Immunother 2009 0.87
122 Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol 2004 0.85
123 TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol 2014 0.85
124 The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations. Curr Drug Targets 2016 0.85
125 T-cells in multiple sclerosis. Results Probl Cell Differ 2010 0.84
126 Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes. Eur J Immunol 2007 0.84
127 CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. J Autoimmun 2003 0.83
128 Multiple sclerosis: genetics, biomarkers, treatments. Curr Opin Neurol 2016 0.83
129 Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin. Neurology 2003 0.82
130 Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest 2014 0.81
131 Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One 2012 0.81
132 Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Mult Scler 2013 0.80
133 Corrigendum: multiple sclerosis-a quiet revolution. Nat Rev Neurol 2015 0.80
134 Prostaglandin E2 affects T cell responses through modulation of CD46 expression. J Immunol 2012 0.80
135 Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cell Immunol 2002 0.80
136 A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol 2010 0.79
137 Immunology. An innate role for IL-17. Science 2011 0.79
138 TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. J Clin Invest 2016 0.79
139 Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function. J Exp Med 2003 0.78
140 Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One 2011 0.77
141 Characterization of in vivo expanded OspA-specific human T-cell clones. Clin Immunol 2005 0.77
142 Perspective: Deconstructing a disease. Nature 2012 0.76
143 Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Dis Markers 2006 0.76
144 Genetic analysis of multiple sclerosis. J Autoimmun 2003 0.75
145 Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B 2010 0.75
146 Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. J Clin Invest 2017 0.75
147 Re: GAMES issue study: Are international genetic consortia functional? J Neuroimmunol 2004 0.75