PubRank

Clifford A Lowell

Author PubWeight™ 143.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 2006 3.68
2 Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 2003 3.60
3 Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 2005 3.57
4 Syk is required for integrin signaling in neutrophils. Immunity 2002 3.39
5 The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A 2004 3.15
6 Transfusion-related acute lung injury: incidence and risk factors. Blood 2011 3.12
7 Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 2009 3.08
8 Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 2005 2.97
9 Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002 2.92
10 The ins and outs of leukocyte integrin signaling. Annu Rev Immunol 2009 2.76
11 Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 2008 2.67
12 Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest 2006 2.50
13 Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity 2007 2.43
14 Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 2003 2.04
15 The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity 2010 1.97
16 The multifaceted functions of neutrophils. Annu Rev Pathol 2013 1.97
17 Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A 2003 1.94
18 Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol 2005 1.81
19 Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity 2013 1.80
20 PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med 2008 1.79
21 Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity 2006 1.79
22 Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A 2011 1.76
23 Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity 2011 1.72
24 Neutrophils mediate antibody-induced antitumor effects in mice. Blood 2013 1.66
25 Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest 2004 1.58
26 Molecular editing of cellular responses by the high-affinity receptor for IgE. Science 2014 1.53
27 The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE 2007 1.50
28 Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep 2012 1.45
29 G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood 2005 1.45
30 Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res 2013 1.42
31 Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 2010 1.41
32 Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 2004 1.40
33 Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol 2004 1.39
34 Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 2009 1.34
35 G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood 2003 1.30
36 Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med 2010 1.29
37 Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev 2009 1.25
38 Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol 2005 1.25
39 The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity 2005 1.25
40 Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol 2008 1.24
41 The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 2007 1.24
42 Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem 2012 1.23
43 The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev 2009 1.23
44 Immunoreceptor-like signaling by beta 2 and beta 3 integrins. Trends Cell Biol 2007 1.21
45 Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity 2003 1.21
46 STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood 2014 1.20
47 Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood 2009 1.18
48 SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity 2003 1.17
49 Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. Blood 2002 1.17
50 Convergence of immunoreceptor and integrin signaling. Immunol Rev 2007 1.16
51 Src family kinases mediate neutrophil adhesion to adherent platelets. Blood 2006 1.16
52 Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest 2008 1.16
53 Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol 2004 1.16
54 Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol 2011 1.15
55 The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol 2007 1.14
56 B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A 2011 1.12
57 Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 2006 1.12
58 Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med 2014 1.11
59 Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood 2008 1.11
60 IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol 2011 1.10
61 Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol 2013 1.09
62 The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling. J Immunol 2004 1.09
63 Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood 2006 1.07
64 Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med 2012 1.07
65 Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J Immunol 2004 1.06
66 Lyn kinase promotes erythroblast expansion and late-stage development. Blood 2006 1.06
67 IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood 2005 1.06
68 Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J 2006 1.05
69 Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell 2013 1.04
70 Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A 2013 1.03
71 The diverse functions of Src family kinases in macrophages. Front Biosci 2008 1.01
72 B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A 2011 1.01
73 An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem 2010 1.00
74 B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol 2013 1.00
75 Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 2005 0.99
76 The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol 2005 0.98
77 Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res 2009 0.98
78 Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol 2011 0.97
79 The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol 2005 0.97
80 Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol 2005 0.96
81 Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg 2012 0.95
82 A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood 2013 0.95
83 Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol 2010 0.94
84 The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 2003 0.94
85 Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol 2007 0.93
86 Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol 2003 0.92
87 Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol 2003 0.92
88 The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol 2011 0.91
89 Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol 2008 0.91
90 The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun 2009 0.88
91 c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett 2010 0.87
92 Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement. J Cell Sci 2012 0.87
93 Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity 2011 0.87
94 Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol 2002 0.85
95 Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol 2009 0.85
96 Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol 2008 0.84
97 Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol 2013 0.84
98 Leukocyte adhesion deficiency syndrome: a controversy solved. Immunol Cell Biol 2009 0.83
99 The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res 2005 0.82
100 Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood 2006 0.81
101 Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS One 2013 0.80
102 Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch 2005 0.79
103 LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest 2016 0.79
104 Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 2016 0.75