Published in Blood on November 06, 2009
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The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages. Blood (2014) 1.57
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Dynamics of podosome stiffness revealed by atomic force microscopy. Proc Natl Acad Sci U S A (2010) 1.10
Macrophage mesenchymal migration requires podosome stabilization by filamin A. J Biol Chem (2012) 0.94
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The podosome marker protein Tks5 regulates macrophage invasive behavior. Cytoskeleton (Hoboken) (2011) 0.86
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Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. Oncotarget (2015) 0.82
The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol (2015) 0.80
Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J Cell Sci (2014) 0.78
Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J (2013) 0.77
HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef. Front Immunol (2015) 0.77
Progesterone and Src family inhibitor PP1 synergistically inhibit cell migration and invasion of human basal phenotype breast cancer cells. Biomed Res Int (2015) 0.76
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Cell motility is decreased in macrophages activated by cancer cell-conditioned medium. Biomol Ther (Seoul) (2013) 0.76
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Nanomechanical measurement of adhesion and migration of leukemia cells with phorbol 12-myristate 13-acetate treatment. Int J Nanomedicine (2016) 0.75
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Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell (2005) 9.06
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol (2005) 7.47
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
Trophic macrophages in development and disease. Nat Rev Immunol (2009) 5.37
One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol (2009) 5.07
Inflammation and atherosclerosis. Annu Rev Pathol (2006) 4.47
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol (2007) 4.23
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Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol (2008) 3.26
Invadopodia: specialized cell structures for cancer invasion. Clin Exp Metastasis (2006) 3.05
Interstitial leukocyte migration and immune function. Nat Immunol (2008) 2.99
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood (2003) 2.40
Limiting inflammatory responses during activation of innate immunity. Nat Immunol (2005) 2.33
Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med (1981) 2.25
Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest (2008) 2.16
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Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev (2007) 1.99
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res (2006) 1.96
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Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity (2006) 1.88
Invadopodia and podosomes in tumor invasion. Eur J Cell Biol (2005) 1.75
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene (2006) 1.73
Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol (2008) 1.68
Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J Immunol (2004) 1.64
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res (2009) 1.63
Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation. Eur J Cell Biol (2008) 1.59
Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci (1999) 1.57
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood (1996) 1.37
Proteolytic and non-proteolytic migration of tumour cells and leucocytes. Biochem Soc Symp (2003) 1.37
Kinetics of changes in peritoneal cell populations following acute inflammation. Cell Immunol (1989) 1.37
Tumor cell migration in three dimensions. Methods Enzymol (2006) 1.18
Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest (2008) 1.16
Regulation of phagocyte migration and recruitment by Src-family kinases. Cell Mol Life Sci (2008) 1.16
Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes. Traffic (2005) 1.14
Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. Eur J Cell Biol (2008) 1.09
The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis. PLoS Pathog (2008) 1.06
The role of neutrophils and monocytes in innate immunity. Contrib Microbiol (2008) 1.06
Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis. PLoS Pathog (2008) 1.06
Macrophages in rheumatoid arthritis. Histol Histopathol (2007) 1.02
WASP and WIP regulate podosomes in migrating leukocytes. J Microsc (2008) 1.01
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Factors underlying chronic inflammation in rheumatoid arthritis. Arch Immunol Ther Exp (Warsz) (2004) 0.99
p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner. J Biol Chem (2002) 0.92
Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells. J Cell Physiol (2007) 0.89
Re-arrangements of podosome structures are observed when Hck is activated in myeloid cells. Eur J Cell Biol (2005) 0.87
The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms. Eur J Cancer (2008) 0.80
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol (2006) 3.68
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57
Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med (2007) 3.22
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A (2004) 3.15
Transfusion-related acute lung injury: incidence and risk factors. Blood (2011) 3.12
Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest (2009) 3.08
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol (2005) 2.97
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity (2008) 2.67
Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest (2006) 2.50
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity (2007) 2.43
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04
Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis. Infect Immun (2002) 1.97
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97
The multifaceted functions of neutrophils. Annu Rev Pathol (2013) 1.97
MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions. Clin Chem (2010) 1.95
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A (2003) 1.94
Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol (2005) 1.81
Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity (2013) 1.80
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79
Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity (2006) 1.79
Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.76
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity (2011) 1.72
Syk-dependent mTOR activation in follicular lymphoma cells. Blood (2006) 1.68
Neutrophils mediate antibody-induced antitumor effects in mice. Blood (2013) 1.66
Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures. J Immunol (2009) 1.65
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res (2009) 1.63
Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma. JAMA (2004) 1.60
Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe (2011) 1.59
Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest (2004) 1.58
PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol (2002) 1.58
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7. Curr Biol (2008) 1.55
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE (2007) 1.50
Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively. J Immunol (2002) 1.49
Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice. Crit Care Med (2011) 1.48
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood (2009) 1.47
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood (2005) 1.45
Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res (2013) 1.42
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med (2010) 1.41
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol (2004) 1.40
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood (2009) 1.34
Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. Cancer Res (2010) 1.30
G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood (2003) 1.30
Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med (2010) 1.29
Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity (2005) 1.25
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol (2008) 1.24
Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res (2013) 1.24
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood (2007) 1.24
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem (2012) 1.23
The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23
Macrophage podosomes go 3D. Eur J Cell Biol (2011) 1.22
Immunoreceptor-like signaling by beta 2 and beta 3 integrins. Trends Cell Biol (2007) 1.21
Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity (2003) 1.21
STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood (2014) 1.20
SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity (2003) 1.17
Surface-exposed glycopeptidolipids of Mycobacterium smegmatis specifically inhibit the phagocytosis of mycobacteria by human macrophages. Identification of a novel family of glycopeptidolipids. J Biol Chem (2003) 1.17
Convergence of immunoreceptor and integrin signaling. Immunol Rev (2007) 1.16
Src family kinases mediate neutrophil adhesion to adherent platelets. Blood (2006) 1.16
Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro. Cell Microbiol (2007) 1.16
Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest (2008) 1.16
Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol (2004) 1.16
Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol (2011) 1.15
Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes. Traffic (2005) 1.14
The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol (2007) 1.14
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A (2011) 1.12
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med (2006) 1.12
Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med (2014) 1.11
Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep. J Gen Virol (2006) 1.11
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood (2008) 1.11
Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments. Biophys J (2011) 1.10
LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome. Hum Mol Genet (2003) 1.10
Dynamics of podosome stiffness revealed by atomic force microscopy. Proc Natl Acad Sci U S A (2010) 1.10
IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol (2011) 1.10
Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol (2013) 1.09
Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. Eur J Cell Biol (2008) 1.09
The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling. J Immunol (2004) 1.09
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines. Eur J Neurosci (2005) 1.07
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07
The protein tyrosine kinase Hck is located on lysosomal vesicles that are physically and functionally distinct from CD63-positive lysosomes in human macrophages. J Cell Sci (2002) 1.07
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IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood (2005) 1.06