Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins.

PubWeight™: 3.26‹?› | Rank: Top 1%

🔗 View Article (PMC 21641)

Published in Proc Natl Acad Sci U S A on September 15, 1998

Authors

Z K Yu1, J L Gervais, H Zhang

Author Affiliations

1: Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Articles citing this

(truncated to the top 100)

p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer (2007) 3.28

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev (1999) 3.11

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08

Ubiquitin, hormones and biotic stress in plants. Ann Bot (2007) 2.77

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev (2008) 2.71

Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1. J Virol (2004) 2.69

Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A (2001) 2.55

Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal (2010) 2.44

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell (2007) 2.35

Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol (2012) 2.34

P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med (2008) 2.10

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol Cell Biol (2001) 2.04

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J (2000) 1.91

The paramyxovirus simian virus 5 V protein slows progression of the cell cycle. J Virol (2000) 1.85

SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. EMBO J (2001) 1.83

Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A (2002) 1.82

Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. J Virol (2002) 1.67

Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion. Breast Cancer Res (2013) 1.64

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62

SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Philos Trans R Soc Lond B Biol Sci (1999) 1.62

Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO. J Virol (2001) 1.60

The emerging role of the COP9 signalosome in cancer. Mol Cancer Res (2005) 1.57

Control of cell growth by the SCF and APC/C ubiquitin ligases. Curr Opin Cell Biol (2009) 1.55

Roles of F-box proteins in cancer. Nat Rev Cancer (2014) 1.51

CUL-4A is critical for early embryonic development. Mol Cell Biol (2002) 1.51

Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway. J Virol (2005) 1.50

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. Br J Cancer (2009) 1.49

Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase. Cell Cycle (2011) 1.49

Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways. Cell Div (2007) 1.42

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol Cell Biol (2004) 1.40

The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Mol Cell Biol (2006) 1.31

Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Cell Host Microbe (2013) 1.27

The ASK1 and ASK2 genes are essential for Arabidopsis early development. Plant Cell (2003) 1.26

The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J Virol (2004) 1.25

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol (2000) 1.24

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. J Biol Chem (2008) 1.22

Skp2: a novel potential therapeutic target for prostate cancer. Biochim Biophys Acta (2011) 1.21

A narrow segment of maternal uniparental disomy of chromosome 7q31-qter in Silver-Russell syndrome delimits a candidate gene region. Am J Hum Genet (2000) 1.20

Degradation of p21cip1 in cells productively infected with human cytomegalovirus. J Virol (2001) 1.19

Cullin-RING Ligases as attractive anti-cancer targets. Curr Pharm Des (2013) 1.19

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer (2006) 1.18

Cullins and cancer. Genes Cancer (2010) 1.16

Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. J Cell Biol (2010) 1.15

The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PLoS One (2012) 1.15

Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis. Plant Physiol (2003) 1.14

The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. Hum Mol Genet (2002) 1.12

F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet (2012) 1.11

Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathog (2011) 1.07

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer (2006) 1.07

Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol (2011) 1.06

14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol (2010) 1.06

Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal (2014) 1.06

Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes. Am J Pathol (2004) 1.05

Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on chromosome 10q. Am J Pathol (2001) 1.05

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance. Front Oncol (2012) 1.04

Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0. Proc Natl Acad Sci U S A (2002) 1.03

Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination. Mol Cell Biol (2004) 1.02

Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation. Invest Ophthalmol Vis Sci (2004) 1.02

The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol (2012) 1.01

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol (2002) 1.00

JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci U S A (2009) 1.00

Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. Hum Mol Genet (2010) 1.00

Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Mol Biol Cell (2008) 0.98

Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues. Mol Cancer (2003) 0.98

Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res (2007) 0.98

Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3. Oncogene (2014) 0.98

Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells. Br J Cancer (2014) 0.96

Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chin J Cancer (2011) 0.95

Skp2 is a promising therapeutic target in breast cancer. Front Oncol (2012) 0.95

CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol (2012) 0.95

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol Cell Biol (2011) 0.95

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3. PLoS One (2013) 0.94

Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. J Virol (2003) 0.93

The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase. J Virol (2010) 0.93

Targeting the ubiquitin pathway for cancer treatment. Biochim Biophys Acta (2014) 0.93

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol Cancer Ther (2008) 0.92

Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells. Oncotarget (2015) 0.91

Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. J Biol Chem (2009) 0.91

Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation. Invest Ophthalmol Vis Sci (2005) 0.91

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth. Oncotarget (2014) 0.90

CRL Ubiquitin Ligases and DNA Damage Response. Front Oncol (2012) 0.89

Coordination of cell growth and division by the ubiquitin-proteasome system. Semin Cell Dev Biol (2012) 0.89

p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels. J Cell Sci (2011) 0.87

Recent advances in SCF ubiquitin ligase complex: Clinical implications. Biochim Biophys Acta (2016) 0.85

The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J (2014) 0.84

RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation. Neoplasia (2013) 0.84

Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage. Cell Div (2010) 0.84

Amniotic membrane-derived cells inhibit proliferation of cancer cell lines by inducing cell cycle arrest. J Cell Mol Med (2012) 0.84

Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle. Philos Trans R Soc Lond B Biol Sci (1999) 0.83

The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase. Mol Cell Biol (2015) 0.83

DNA replication licensing control and rereplication prevention. Protein Cell (2010) 0.83

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun (2017) 0.83

Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. Am J Pathol (2013) 0.81

The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol (2013) 0.81

Regulation of Androgen Receptor by E3 Ubiquitin Ligases: for More or Less. Receptors Clin Investig (2014) 0.80

Articles cited by this

Cancer cell cycles. Science (1996) 21.29

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell (1997) 11.62

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell (1996) 11.22

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science (1995) 9.79

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell (1994) 9.25

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell (1997) 8.97

How proteolysis drives the cell cycle. Science (1996) 8.59

Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell (1991) 5.98

Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev (1997) 5.49

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev (1997) 5.22

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell (1996) 4.11

p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell (1995) 4.08

At the heart of the budding yeast cell cycle. Trends Genet (1996) 3.75

The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J (1996) 3.12

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol Cell Biol (1994) 3.05

Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev (1996) 2.81

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell (1993) 2.57

Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science (1993) 2.56

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol (1997) 2.41

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev (1994) 2.39

Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol (1996) 1.41

A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. Proc Natl Acad Sci U S A (1996) 1.38

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95

p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55

Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00

Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. Science (2001) 6.52

The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med (2001) 5.89

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36

Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA (1999) 4.98

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90

Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79

Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein. Proc Natl Acad Sci U S A (1994) 4.67

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64

Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58

Familial transmission of substance use disorders. Arch Gen Psychiatry (1998) 4.57

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20

Aggregation-based crystal growth and microstructure development in natural iron oxyhydroxide biomineralization products. Science (2000) 4.03

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70

XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66

Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64

The DISC Predictive Scales (DPS): efficiently screening for diagnoses. J Am Acad Child Adolesc Psychiatry (2001) 3.52

Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer. N Engl J Med (1998) 3.47

Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. J Neurosci (1998) 3.45

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A (2000) 3.44

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42

PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis. Science (1999) 3.42

Microcolinearity in sh2-homologous regions of the maize, rice, and sorghum genomes. Proc Natl Acad Sci U S A (1997) 3.29

Erythropoietin response is blunted in critically ill patients. Intensive Care Med (1997) 3.20

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (1995) 3.06

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00

Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. Am J Public Health (2001) 2.96

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature (1997) 2.93

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med (2001) 2.87

West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg Infect Dis (2001) 2.85

An information-based sequence distance and its application to whole mitochondrial genome phylogeny. Bioinformatics (2001) 2.80

Course of tic severity in Tourette syndrome: the first two decades. Pediatrics (1998) 2.75

Medical decision support: experience with implementing the Arden Syntax at the Columbia-Presbyterian Medical Center. Proc Annu Symp Comput Appl Med Care (1995) 2.74

Interaction of short-range repressors with Drosophila CtBP in the embryo. Science (1998) 2.61

Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene. N Engl J Med (1996) 2.60

Regional brain and ventricular volumes in Tourette syndrome. Arch Gen Psychiatry (2001) 2.59

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nat Cell Biol (2000) 2.55

Use of genotypic resistance testing to guide hiv therapy: clinical impact and cost-effectiveness. Ann Intern Med (2001) 2.47

BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene (1998) 2.39

Structure of a cytochrome P450-redox partner electron-transfer complex. Proc Natl Acad Sci U S A (1999) 2.30

A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry (1998) 2.27

The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology (2000) 2.26

Progress in thermal comfort research over the last twenty years. Indoor Air (2013) 2.24

dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo. EMBO J (1998) 2.22

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem (1999) 2.21

Post-earthquake quality of life and psychological well-being: longitudinal evaluation in a rural community sample in northern China. Psychiatry Clin Neurosci (2000) 2.20

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18

ABA plays a central role in mediating the regulatory effects of nitrate on root branching in Arabidopsis. Plant J (2001) 2.15

An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biol Psychiatry (1999) 2.12

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10

Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol (2015) 2.07

Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions. Cardiovasc Res (2001) 2.05

Genome-wide association scan for childhood caries implicates novel genes. J Dent Res (2011) 2.05

Conditional mutator phenotypes in hMSH2-deficient tumor cell lines. Science (1997) 2.04

Umbilical cord mesenchymal stem cell transplantation in drug-induced Stevens-Johnson syndrome. J Eur Acad Dermatol Venereol (2012) 2.03

The correlation between the mouth diameter of left atrial appendage and stroke risk score in patients with atrial fibrillation. Eur Rev Med Pharmacol Sci (2015) 2.02

Relationship between oxygen uptake and oxygen delivery in septic patients: effects of prostacyclin versus dobutamine. Crit Care Med (1993) 2.00

Enterovirus replication in valvular tissue from patients with chronic rheumatic heart disease. Eur Heart J (2002) 1.98

Validity of self-reported height and weight in a Japanese workplace population. Int J Obes (Lond) (2005) 1.97

Red spectral shift and enhanced quantum efficiency in phonon-free photoluminescence from silicon nanocrystals. Nat Nanotechnol (2010) 1.96

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene (2012) 1.95

A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis. Nat Genet (1995) 1.93

A flexible light-directed DNA chip synthesis gated by deprotection using solution photogenerated acids. Nucleic Acids Res (2001) 1.92

HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Virology (1993) 1.92

Models of cardiac tissue electrophysiology: progress, challenges and open questions. Prog Biophys Mol Biol (2010) 1.92

Experimental yellow fever virus infection in the Golden Hamster (Mesocricetus auratus). I. Virologic, biochemical, and immunologic studies. J Infect Dis (2001) 1.90

Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet (1996) 1.90

Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli. J Bacteriol (1988) 1.89

The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3. J Gen Virol (2000) 1.89

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene (2010) 1.88

Symptoms of obsessive-compulsive disorder. Am J Psychiatry (1997) 1.88

Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env. J Virol (2006) 1.87

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol (2001) 1.86

Non-invasive prenatal testing for fetal chromosomal abnormalities by low-coverage whole-genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center. Ultrasound Obstet Gynecol (2014) 1.85

Experimental yellow fever virus infection in the Golden hamster (Mesocricetus auratus). II. Pathology. J Infect Dis (2001) 1.84

Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system. Hypertension (2000) 1.82

Learning from the Arabidopsis experience. The next gene search paradigm. Plant Physiol (2001) 1.82

A consolidated linkage map for rainbow trout (Oncorhynchus mykiss). Anim Genet (2003) 1.81

A comprehensive analysis of high school genetics standards: are states keeping pace with modern genetics? CBE Life Sci Educ (2011) 1.80

NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol (2007) 1.79

A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet (1999) 1.78

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J Biol Chem (2001) 1.76

Obesity and 33-year follow-up for coronary heart disease and cancer mortality. Epidemiology (1997) 1.75

Longitudinal study of earthquake-related PTSD in a randomly selected community sample in north China. Am J Psychiatry (2000) 1.75

Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. Ann Oncol (2011) 1.74

A clinical trial of creatine in ALS. Neurology (2004) 1.73

Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol (2001) 1.73

Genetic and biologic characterization of Toxoplasma gondii isolates of cats from China. Vet Parasitol (2007) 1.73

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology (2006) 1.73

Transcriptional coregulators in development. Science (1999) 1.72

Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging (2007) 1.72

Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. Mol Cell (2000) 1.70