Published in Protein Cell on March 01, 2014
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discov (2015) 1.17
Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function. J Neurosci (2015) 1.06
mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab (2014) 1.05
Localization of mTORC2 activity inside cells. J Cell Biol (2017) 0.86
Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology (2014) 0.84
mTOR kinase: a possible pharmacological target in the management of chronic pain. Biomed Res Int (2015) 0.82
The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells. J Biol Chem (2016) 0.76
Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease. Neuroendocrinology (2016) 0.75
mTOR function and therapeutic targeting in breast cancer. Am J Cancer Res (2017) 0.75
Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. Neurobiol Learn Mem (2016) 0.75
Crosstalks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients. Biosci Rep (2016) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
TOR signaling in growth and metabolism. Cell (2006) 35.29
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
mTOR signaling in growth control and disease. Cell (2012) 29.21
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
mTOR and cancer: insights into a complex relationship. Nat Rev Cancer (2006) 11.86
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol (2007) 8.07
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J (2008) 7.18
Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet (2005) 7.15
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett (1996) 6.16
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (2011) 5.73
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J (2008) 4.79
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev (2006) 4.78
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab (2008) 4.36
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38
Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol (2009) 3.32
p53 dynamics control cell fate. Science (2012) 3.30
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev (2005) 3.25
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie (2005) 3.20
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94
Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84
Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med (2012) 2.38
mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature (2013) 2.38
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. Sci Signal (2009) 2.16
Molecular organization of target of rapamycin complex 2. J Biol Chem (2005) 2.15
AKT signaling in normal and malignant cells. Oncogene (2005) 2.14
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells (2004) 2.06
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell (2011) 2.02
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol (2006) 1.82
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab (2013) 1.54
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell (2010) 1.34
Deconvoluting mTOR biology. Cell Cycle (2012) 1.16
Evolution of the TOR pathway. J Mol Evol (2011) 0.95
SnapShot: mTORC1 signaling at the lysosomal surface. Cell (2012) 0.89
Decoding the insulin signal. Mol Cell (2012) 0.82
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell (2005) 3.51
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol (2009) 2.76
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol (2006) 2.60
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood (2010) 2.37
Retracted MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem (2010) 2.34
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell (2012) 2.30
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell (2011) 2.03
Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify pre-op TIMI 45--a pilot study. Clin Cardiol (2015) 2.01
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther (2010) 1.90
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87
Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta (2002) 1.86
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Lett (2012) 1.64
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell (2012) 1.48
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J Biol Chem (2002) 1.45
Acetylation-dependent regulation of Skp2 function. Cell (2012) 1.40
Bioluminescent imaging of Cdk2 inhibition in vivo. Nat Med (2004) 1.37
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell (2010) 1.34
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol (2004) 1.31
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell (2010) 1.29
Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. J Invest Dermatol (2013) 1.22
Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem (2009) 1.22
Skp2: a novel potential therapeutic target for prostate cancer. Biochim Biophys Acta (2011) 1.21
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19
SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med (2012) 1.18
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell (2009) 1.18
Mcl-1 ubiquitination and destruction. Oncotarget (2011) 1.17
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol (2008) 1.16
Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. J Immunol (2004) 1.14
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem (2004) 1.13
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) (2012) 1.12
Retracted Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem (2009) 1.12
Aberrant regulation of FBW7 in cancer. Oncotarget (2014) 1.08
The two faces of FBW7 in cancer drug resistance. Bioessays (2011) 1.08
MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell (2013) 1.05
SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Rep (2012) 1.03
Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep (2011) 1.00
High-resolution mapping of the brown planthopper resistance gene Bph6 in rice and characterizing its resistance in the 9311 and Nipponbare near isogenic backgrounds. Theor Appl Genet (2010) 0.98
Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget (2010) 0.98
Increased IL-33 in synovial fluid and paired serum is associated with disease activity and autoantibodies in rheumatoid arthritis. Clin Dev Immunol (2013) 0.98
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis Rheumatol (2014) 0.98
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One (2012) 0.98
Development and characterization of japonica rice lines carrying the brown planthopper-resistance genes BPH12 and BPH6. Theor Appl Genet (2011) 0.97
An evolving role for DEPTOR in tumor development and progression. Neoplasia (2012) 0.96
SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget (2013) 0.96
Skp2 is a promising therapeutic target in breast cancer. Front Oncol (2012) 0.95
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Div (2009) 0.92
Applications of novel monoclonal antibodies specific for synuclein-gamma in evaluating its levels in sera and cancer tissues from colorectal cancer patients. Cancer Lett (2008) 0.92
Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy. Am Heart J (2011) 0.91
Cdc20: a potential novel therapeutic target for cancer treatment. Curr Pharm Des (2013) 0.90
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Mol Cell Biol (2013) 0.89
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget (2012) 0.88
Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell (2003) 0.88
Evaluating spatial-temporal dynamics of net primary productivity of different forest types in northeastern China based on improved FORCCHN. PLoS One (2012) 0.87
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Res (2013) 0.87
Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8). J Med Chem (2006) 0.87
Characteristics of Sjögren's syndrome in rheumatoid arthritis. Rheumatology (Oxford) (2013) 0.86
IκB Kinase ε expression in pancreatic ductal adenocarcinoma. Am J Clin Pathol (2011) 0.86
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget (2012) 0.86
Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families. Neurobiol Aging (2009) 0.86
miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer. Cancer Discov (2012) 0.86
Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis. Arthritis Res Ther (2014) 0.86
Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway. J Biol Chem (2008) 0.85
Synergy of satellite and ground based observations in estimation of particulate matter in eastern China. Sci Total Environ (2012) 0.84
Association of STAT4 gene polymorphism with increased susceptibility of rheumatoid arthritis in a northern Chinese Han subpopulation. Int J Rheum Dis (2013) 0.83
Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol (2014) 0.83
Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Res (2013) 0.83
A rice lectin receptor-like kinase that is involved in innate immune responses also contributes to seed germination. Plant J (2013) 0.83
SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget (2014) 0.83
Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1. Protein Cell (2010) 0.82
Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population. Ann Rheum Dis (2011) 0.81
Synthesis and antitumor activity of a new mixed-ligand complex di-n-butyl-(4-chlorobenzohydroxamato)tin(IV) chloride. J Inorg Biochem (2008) 0.81
Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF. Nucleus (2015) 0.81
Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer. J Genet Genomics (2013) 0.81
Synthesis, structure and dehydrogenation of magnesium amidoborane monoammoniate. Chem Commun (Camb) (2010) 0.80
Targeting prostate cancer stem cells for cancer therapy. Discov Med (2012) 0.80
Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem (2011) 0.80
Relative efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation by network meta-analysis. J Cardiovasc Med (Hagerstown) (2014) 0.80
Heck-type coupling vs. conjugate addition in phosphine-rhodium catalyzed reactions of aryl boronic acids with alpha,beta-unsaturated carbonyl compounds: a systematic investigation. Dalton Trans (2007) 0.80
DEPTOR ubiquitination and destruction by SCF(β-TrCP). Am J Physiol Endocrinol Metab (2012) 0.80
Dickkopf-1 as potential biomarker to evaluate bone erosion in systemic lupus erythematosus. J Clin Immunol (2010) 0.79
Follow-up study of abnormal biological indicators and gene expression in the peripheral blood of three accidentally exposed persons. J Radiat Res (2013) 0.79
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem (2016) 0.79
Cell cycle status dictates effectiveness of rapamycin. Cell Cycle (2015) 0.78
The functions of F-box proteins in regulating the epithelial to mesenchymal transition. Curr Pharm Des (2015) 0.78
Synthesis of 3-amino-1,2,4-benzothiadi- azine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation. J Org Chem (2005) 0.78
Autoantibodies to phosphorylcholine and cardiovascular outcomes in patients with acute coronary syndromes in the ATLAS ACS-TIMI 46 trial. J Thromb Thrombolysis (2014) 0.77
Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1. Proc Natl Acad Sci U S A (2012) 0.77
Role of progressive widening of the temporal excitable gap for perpetuation of atrial fibrillation in the goat. Circ J (2010) 0.76
Superior molecularly altered influenza virus hemagglutinin peptide 308-317 inhibits collagen-induced arthritis by inducing CD4+ Treg cell expansion. Arthritis Rheum (2012) 0.76
Ammonium diphenyl-phosphinate monohydrate. Acta Crystallogr Sect E Struct Rep Online (2008) 0.75
Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift. Cell Mol Immunol (2011) 0.75