Published in Nature on December 07, 1989
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p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol (1993) 1.85
Inhibition of viral and cellular promoters by human wild-type p53. J Virol (1992) 1.83
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control. Proc Natl Acad Sci U S A (1998) 1.83
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p53 is covalently linked to 5.8S rRNA. Mol Cell Biol (1992) 1.65
Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations. Proc Natl Acad Sci U S A (1991) 1.65
Mutations in p53 as potential molecular markers for human breast cancer. Proc Natl Acad Sci U S A (1991) 1.65
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Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.62
Down-regulation of beta-catenin by activated p53. Mol Cell Biol (2001) 1.60
Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Mol Cell Biol (1990) 1.58
Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci U S A (1993) 1.58
Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue. Am J Pathol (1992) 1.57
p53 in chronic myelogenous leukemia in acute phase. Proc Natl Acad Sci U S A (1991) 1.56
Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. J Virol (1992) 1.56
The tumor suppressor p53 is bound to RNA by a stable covalent linkage. Mol Cell Biol (1991) 1.56
A role for p53 in base excision repair. EMBO J (2001) 1.56
Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells. Proc Natl Acad Sci U S A (1999) 1.52
Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci U S A (1991) 1.52
MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol (1998) 1.49
A DNA binding domain is contained in the C-terminus of wild type p53 protein. Nucleic Acids Res (1991) 1.49
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev (2004) 1.48
Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer (1992) 1.47
The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J Virol (1991) 1.46
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Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells. J Virol (1992) 1.44
Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest (1995) 1.43
Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proc Natl Acad Sci U S A (1996) 1.42
G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest (2002) 1.41
Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A (1990) 1.39
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J (1992) 1.39
Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol Cell Biol (1991) 1.39
Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder. Br J Cancer (1991) 1.39
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Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer. J Clin Invest (1990) 1.38
Human p53 inhibits growth in Schizosaccharomyces pombe. Mol Cell Biol (1992) 1.38
The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell Death Differ (2015) 1.38
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Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Genes Dev (1999) 1.37
Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. Br J Cancer (1992) 1.36
An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma. Proc Natl Acad Sci U S A (1992) 1.33
p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol (1995) 1.32
Prognostic significance of TP53 alterations in breast carcinoma. Br J Cancer (1993) 1.30
Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am J Pathol (1991) 1.29
Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients. Proc Natl Acad Sci U S A (1993) 1.28
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