Published in J Exp Med on March 03, 2014
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma. Arch Biochem Biophys (2014) 0.89
Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations. Mucosal Immunol (2016) 0.77
TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis (2015) 0.75
B-cell tolerance and autoimmunity. F1000Res (2017) 0.75
BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells. Curr Opin Immunol (2015) 0.75
The Role of TLR4 on B Cell Activation and Anti-β2GPI Antibody Production in the Antiphospholipid Syndrome. J Immunol Res (2016) 0.75
Identification of PTPN1 as a novel negative regulator of the JNK MAPK pathway using a synthetic screening for pathway-specific phosphatases. Sci Rep (2017) 0.75
Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity. Clin Rev Allergy Immunol (2017) 0.75
Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes. Mol Cell Proteomics (2017) 0.75
2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis (2010) 12.12
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med (1999) 7.41
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol (1996) 6.91
An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science (2001) 5.73
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci U S A (1997) 5.63
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
Mechanisms and functions of p38 MAPK signalling. Biochem J (2010) 4.59
Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med (2006) 3.66
Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res (1988) 3.66
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell (1992) 3.59
Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol Rev (2009) 3.56
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med (2005) 3.43
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity (2001) 3.43
Activation of autoreactive B cells by CpG dsDNA. Immunity (2003) 3.40
Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A (2006) 3.32
B-lymphocyte contributions to human autoimmune disease. Immunol Rev (2008) 2.89
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem (2001) 2.65
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity (2007) 2.28
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell (2002) 2.10
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem (2000) 2.02
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Protein tyrosine phosphatases in autoimmunity. Annu Rev Immunol (2008) 1.90
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res (2007) 1.82
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J (1993) 1.75
Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells. Haematologica (2010) 1.61
Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab. Blood (2010) 1.57
Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annu Rev Immunol (2007) 1.56
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol (2004) 1.47
Tyrosine kinases and their substrates in B lymphocytes. Immunol Rev (2009) 1.46
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature (2004) 1.43
Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol (1976) 1.43
Therapeutic targeting of B cells for rheumatic autoimmune diseases. Pharmacol Rev (2011) 1.35
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 1.27
p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol (1998) 1.26
Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. Mol Cell Biol (1998) 1.23
Differential activities of protein tyrosine phosphatases in intact cells. J Biol Chem (1993) 1.21
Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytes. J Immunol (1979) 1.20
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res (2009) 1.16
Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry (2003) 1.11
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res (2005) 1.11
Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation. J Immunol (1990) 1.10
Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol (2008) 1.06
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy. Arthritis Res Ther (2010) 1.04
Autoantibody detection using indirect immunofluorescence on HEp-2 cells. Ann N Y Acad Sci (2009) 1.04
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02
BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice. J Invest Dermatol (2007) 1.02
The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase. J Biol Chem (2001) 0.96
Technology evaluation: ISIS-113715, Isis. Curr Opin Mol Ther (2004) 0.89
Phenotypic diversity of peripheral blood plasma cells in primary Sjögren's syndrome. Scand J Immunol (2011) 0.84
A role for B cell-activating factor of the TNF family in chemically induced autoimmunity. J Immunol (2005) 0.84
Value of the peripheral blood B-cells subsets in patients with ankylosing spondylitis. Chin Med J (Engl) (2009) 0.83
PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta). Bioorg Med Chem Lett (2007) 0.79
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol (2006) 5.22
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A (2010) 5.05
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity (2006) 3.74
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science (2011) 3.66
Maintenance of serum antibody levels. Annu Rev Immunol (2005) 3.20
Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood (2004) 3.17
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol (2005) 3.05
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med (2008) 2.99
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med (2008) 2.97
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J Exp Med (2004) 2.85
Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum (2002) 2.52
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res (2007) 2.50
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol (2005) 2.46
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat Immunol (2002) 2.35
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol (2008) 2.29
A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. Am J Respir Crit Care Med (2006) 2.28
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol (2009) 2.19
Efficacy and safety of rituximab treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitides: results from a German registry (GRAID). J Rheumatol (2012) 2.12
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell (2002) 2.10
Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum (2009) 2.04
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04
Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum (2008) 2.00
Memory B and memory plasma cells. Immunol Rev (2010) 1.95
Blood-borne human plasma cells in steady state are derived from mucosal immune responses. Blood (2008) 1.91
Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun (2007) 1.87
Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin Immunol (2010) 1.80
Plasma cell differentiation and survival. Curr Opin Immunol (2008) 1.71
Humoral immunity and long-lived plasma cells. Curr Opin Immunol (2002) 1.63
Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum (2006) 1.62
Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus. Arthritis Rheum (2012) 1.59
Factors masking HMGB1 in human serum and plasma. J Leukoc Biol (2006) 1.56
Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus. Rheumatology (Oxford) (2010) 1.53
Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum (2008) 1.53
Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood (2005) 1.51
Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE. Eur J Immunol (2014) 1.49
Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis. Arthritis Rheumatol (2014) 1.48
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.45
Selective silencing of autoreactive B lymphocytes-Following the Nature's way. Autoimmun Rev (2010) 1.43
Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients. Rheumatology (Oxford) (2009) 1.41
B cell signaling and tumorigenesis. Annu Rev Immunol (2005) 1.40
Composition of clogging material in pancreatic endoprostheses. Gastrointest Endosc (2005) 1.39
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature (2003) 1.39
CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. Arthritis Rheum (2007) 1.38
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J (2008) 1.37
Importance of TRF1 for functional telomere structure. J Biol Chem (2003) 1.37
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene (2003) 1.37
Adaptation of humoral memory. Immunol Rev (2006) 1.29
Oligomeric organization of the B-cell antigen receptor on resting cells. Nature (2010) 1.27
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol (2009) 1.27
Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev (2004) 1.25
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell (2013) 1.25
Autologous stem cell transplantation for systemic lupus erythematosus. Lupus (2004) 1.24
Impact of rituximab on immunoglobulin concentrations and B cell numbers after cyclophosphamide treatment in patients with ANCA-associated vasculitides. PLoS One (2012) 1.23
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood (2009) 1.21
Sodium overload and water influx activate the NALP3 inflammasome. J Biol Chem (2010) 1.20
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19
Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis (2012) 1.18
B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol (2002) 1.18
Certolizumab pegol plus methotrexate provides broad relief from the burden of rheumatoid arthritis: analysis of patient-reported outcomes from the RAPID 2 trial. Ann Rheum Dis (2011) 1.17
Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity (2008) 1.17
A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.17
Autoinhibition and adapter function of Syk. Immunol Rev (2009) 1.16
Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J Exp Med (2004) 1.15
Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab. Ann Rheum Dis (2011) 1.15
Autoantibodies from long-lived 'memory' plasma cells of NZB/W mice drive immune complex nephritis. Ann Rheum Dis (2013) 1.13
Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity. J Autoimmun (2012) 1.13
Perspectives on the nature of BCR-mediated survival signals. Mol Cell (2004) 1.12
Functional analysis of histone methyltransferase g9a in B and T lymphocytes. J Immunol (2008) 1.12
N-linked glycosylation selectively regulates autonomous precursor BCR function. Nat Immunol (2010) 1.11
Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J Exp Med (2003) 1.10
Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities. Immunity (2002) 1.10
Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. Eur J Immunol (2008) 1.09
B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Proc Natl Acad Sci U S A (2010) 1.08
Removal of dying cells and systemic lupus erythematosus. Mod Rheumatol (2005) 1.08
CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations. J Leukoc Biol (2004) 1.08
Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem (2004) 1.07
Involvement of phosphatidylserine, alphavbeta3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages. Arthritis Rheum (2006) 1.07
Bronchoalveolar lavage cytology resembles sarcoidosis in a subgroup of granulomatous CVID. Eur Respir J (2014) 1.06
Long-lived plasma cells and their contribution to autoimmunity. Ann N Y Acad Sci (2005) 1.05
Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus. Arthritis Res Ther (2011) 1.05
Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function. Ann Rheum Dis (2009) 1.04
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination. J Hepatol (2007) 1.04
Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity (2008) 1.04
Autoantibody detection using indirect immunofluorescence on HEp-2 cells. Ann N Y Acad Sci (2009) 1.04
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes Cells (2006) 1.04
Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy. J Immunol (2012) 1.03
The TCR binding site does move. Proc Natl Acad Sci U S A (2007) 1.03
The dissociation activation model of B cell antigen receptor triggering. FEBS Lett (2010) 1.03