Published in PLoS One on March 10, 2014
A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | NCT01829971
Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis. Int J Mol Sci (2016) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res (2008) 54.83
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
GROMACS: fast, flexible, and free. J Comput Chem (2005) 27.22
Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics (2010) 26.76
The Database of Interacting Proteins: 2004 update. Nucleic Acids Res (2004) 23.67
Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25
pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics (2011) 16.75
The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell (1998) 9.96
miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97
miRWalk--database: prediction of possible miRNA binding sites by "walking" the genes of three genomes. J Biomed Inform (2011) 8.50
The IntAct molecular interaction database in 2012. Nucleic Acids Res (2011) 7.49
PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res (2007) 7.07
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
ZINC: a free tool to discover chemistry for biology. J Chem Inf Model (2012) 6.57
The BioGRID interaction database: 2013 update. Nucleic Acids Res (2012) 6.09
miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Res (2010) 5.72
Benchmarking sets for molecular docking. J Med Chem (2006) 5.57
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature (2000) 4.92
TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res (2011) 4.54
A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell (2011) 4.42
starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99
HomoMINT: an inferred human network based on orthology mapping of protein interactions discovered in model organisms. BMC Bioinformatics (2005) 3.75
Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data. Lancet (2013) 3.31
Accurate microRNA target prediction correlates with protein repression levels. BMC Bioinformatics (2009) 3.21
Prediction and validation of microRNAs and their targets. FEBS Lett (2005) 2.99
DOCK 6: combining techniques to model RNA-small molecule complexes. RNA (2009) 2.75
Practical Aspects of microRNA Target Prediction. Curr Mol Med (2011) 2.64
Flexible ligand docking to multiple receptor conformations: a practical alternative. Curr Opin Struct Biol (2008) 2.38
Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase. J Med Chem (2008) 2.14
Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem (2000) 2.07
Clinical applications for microRNAs in cancer. Clin Pharmacol Ther (2012) 2.05
Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist (2006) 1.70
Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am J Physiol Endocrinol Metab (2004) 1.66
Human cancer protein-protein interaction network: a structural perspective. PLoS Comput Biol (2009) 1.54
Intracellular and extracellular microRNAs in breast cancer. Clin Chem (2010) 1.44
Science searches shift up a gear as Google starts Scholar engine. Nature (2004) 1.39
The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2. Nat Clin Pract Oncol (2008) 1.37
miRNAs and estrogen action. Trends Endocrinol Metab (2012) 1.24
Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2. J Biol Chem (2012) 1.23
The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Curr Opin Pharmacol (2010) 1.21
Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements. J Cell Biochem (2004) 1.19
Online resources of cancer data: barriers, benefits and lessons. Brief Bioinform (2010) 1.19
Predicting cancer involvement of genes from heterogeneous data. BMC Bioinformatics (2008) 1.16
Network-based Identification of novel cancer genes. Mol Cell Proteomics (2009) 1.12
Prediction of Associations between microRNAs and Gene Expression in Glioma Biology. PLoS One (2011) 1.10
Derailed estrogen signaling and breast cancer: an authentic couple. Endocr Rev (2012) 1.01
Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers. Breast Cancer Res (2008) 0.98
Selective estrogen receptor modulators (SERMS) and their roles in breast cancer prevention. Trends Mol Med (2002) 0.98
Estradiol-activated estrogen receptor α does not regulate mature microRNAs in T47D breast cancer cells. J Steroid Biochem Mol Biol (2011) 0.93
The holistic integration of virtual screening in drug discovery. Drug Discov Today (2013) 0.90
Analysis of mechanistic pathway models in drug discovery: p38 pathway. Biotechnol Prog (2007) 0.89
Molecular mechanisms of selective estrogen receptor modulator activity in human breast cancer cells: identification of novel nuclear cofactors of antiestrogen-ERα complexes by interaction proteomics. J Proteome Res (2012) 0.86
Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes. Toxicol Sci (2003) 0.85
MicroRNAs and drug resistance of breast cancer: basic evidence and clinical applications. Clin Transl Oncol (2012) 0.85
Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies. J Comput Aided Mol Des (1994) 0.84
Breast cancer prevention: SERMs come of age. Lancet (2013) 0.83
Third-generation SERMs may face uphill battle. J Natl Cancer Inst (2010) 0.81
Force field development and conformational search strategy in the simulation of biomolecular recognition processes. Biochem Soc Trans (1996) 0.78
Discovery of natural estrogen receptor modulators with structure-based virtual screening. Bioorg Med Chem Lett (2013) 0.76