The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discrimination.

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Published in Scand J Immunol on June 01, 2014

Authors

P A Bretscher1

Author Affiliations

1: University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med (1966) 10.03

A cell culture model for T lymphocyte clonal anergy. Science (1990) 9.86

A theory of self-nonself discrimination. Science (1970) 7.99

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The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today (1992) 5.93

Genes and antibodies. Science (1959) 5.63

The mechanism of immunological paralysis. Adv Immunol (1968) 5.53

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THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION. Proc Natl Acad Sci U S A (1955) 4.24

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Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med (1982) 3.34

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Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clin Exp Immunol (1970) 2.62

Allergy and immunology. Annu Rev Med (1957) 2.62

Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med (1991) 2.60

Does T-cell tolerance require a dedicated antigen-presenting cell? Nature (1989) 2.41

CTLA-4 regulates induction of anergy in vivo. Immunity (2001) 2.39

A new analysis of allogeneic interactions. Aust J Exp Biol Med Sci (1975) 2.33

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THE IMMUNE RESPONSE OF BSA TOLERANT RABBITS TO INJECTIONS OF BSA FOLLOWING THE TERMINATION OF THE TOLERANT STATE. J Immunol (1964) 1.53

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Haemolytic icterus (acholuric jaundice) congenital and acquired. J Pathol Bacteriol (1946) 0.99

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