Does T-cell tolerance require a dedicated antigen-presenting cell?

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 6.56

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19

The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med (2000) 5.74

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med (1996) 5.32

Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med (1998) 3.58

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med (2009) 3.38

Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med (2002) 3.35

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci U S A (1993) 3.25

Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med (1997) 2.33

Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation (1996) 1.86

Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency. J Virol (1993) 1.85

Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells (1995) 1.83

Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. Proc Natl Acad Sci U S A (2002) 1.70

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest (1992) 1.64

Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A (2011) 1.54

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc Natl Acad Sci U S A (1992) 1.44

The anatomy of T-cell activation and tolerance. Proc Natl Acad Sci U S A (1996) 1.42

The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discrimination. Scand J Immunol (2014) 1.41

TSLP in epithelial cell and dendritic cell cross talk. Adv Immunol (2009) 1.33

Tolerogenic dendritic cells and their role in transplantation. Semin Immunol (2011) 1.26

Immunologic tolerance in lymphatic filariasis. Diminished parasite-specific T and B lymphocyte precursor frequency in the microfilaremic state. J Clin Invest (1992) 1.24

T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J Exp Med (1997) 1.16

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A (2009) 1.09

Evidence for a single-niche model of positive selection. Proc Natl Acad Sci U S A (1994) 1.05

Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J Exp Med (2002) 0.98

The role of the thymus in tolerance. Transplantation (2010) 0.95

Cell-surface marker analysis of rat thymic dendritic cells. Immunology (1993) 0.95

Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci U S A (2000) 0.93

Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin Exp Immunol (2003) 0.90

Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries? J Exp Med (2000) 0.87

Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival. J Clin Invest (2002) 0.85

Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells. Front Immunol (2011) 0.83

Mixed chimerism and split tolerance: mechanisms and clinical correlations. Chimerism (2012) 0.83

Dendritic cells in systemic lupus erythematosus. Int Rev Immunol (2010) 0.83

The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras. Proc Natl Acad Sci U S A (1991) 0.83

Antigen presentation by dendritic cells in vivo. J Exp Med (2002) 0.80

Intrathymic presentation by dendritic cells and macrophages: their role in selecting T cells with specificity for internal and external nominal antigen. Immunology (1991) 0.80

Costimulatory molecule-deficient dendritic cell progenitors induce T cell hyporesponsiveness in vitro and prolong the survival of vascularized cardiac allografts. Transplant Proc (1997) 0.77

T-cell tolerance induced in nude mice grafted with thymic epithelium. Immunology (1992) 0.75

Tolerance in liver transplantation: Biomarkers and clinical relevance. World J Gastroenterol (2016) 0.75

A murine retrovirus induces proliferation of unique lymphoid cell lines expressing T-cell-receptor structures utilizing common variable region alpha and beta chain genes. Proc Natl Acad Sci U S A (1993) 0.75

Qa-1 restricted recognition of foreign antigen by a gamma delta T-cell hybridoma. Nature (1989) 2.35

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity (1996) 2.28

Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity (1995) 1.25

Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes (1995) 1.21

Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice. J Bone Miner Res (1999) 1.15

Selection of phenotypically distinct NK1.1+ T cells upon antigen expression in the thymus or in the liver. Eur J Immunol (1999) 0.84

Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1. J Immunol (1996) 0.79

Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice. J Immunol (1997) 0.79

RelA regulates the survival of activated effector CD8 T cells. Cell Death Differ (2005) 0.76