Published in Cell on July 01, 1983
Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol (1989) 3.21
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A (1984) 2.51
Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol (1984) 2.48
Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat (2009) 2.21
Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe. J Cell Biol (1985) 2.20
The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. J Cell Biol (1992) 2.07
Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest (2009) 2.06
Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins. J Cell Biol (1986) 1.91
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol (1986) 1.89
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89
Structure of a gene for the human epidermal 67-kDa keratin. Proc Natl Acad Sci U S A (1985) 1.82
Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. EMBO J (1986) 1.81
Elucidating the early stages of keratin filament assembly. J Cell Biol (1990) 1.80
Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences. EMBO J (1987) 1.80
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes. Nucleic Acids Res (1987) 1.73
The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression. J Cell Biol (1990) 1.71
Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells. Proc Natl Acad Sci U S A (1988) 1.66
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A (1984) 1.52
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci U S A (1985) 1.52
Molecular characterization and expression of the stratification-related cytokeratins 4 and 15. J Cell Biol (1988) 1.50
Attachment of vimentin filaments to desmosomal plaques in human meningiomal cells and arachnoidal tissue. J Cell Biol (1984) 1.43
Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex. Proc Natl Acad Sci U S A (1993) 1.41
Intermediate filaments and disease: mutations that cripple cell strength. J Cell Biol (1994) 1.34
Hybrid character of a large neurofilament protein (NF-M): intermediate filament type sequence followed by a long and acidic carboxy-terminal extension. EMBO J (1984) 1.34
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
Differences in keratin synthesis between normal epithelial cells and squamous cell carcinomas are mediated by vitamin A. Proc Natl Acad Sci U S A (1984) 1.32
Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ. J Cell Biol (1988) 1.29
Developmentally regulated cytokeratin gene in Xenopus laevis. Mol Cell Biol (1985) 1.29
The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro. J Cell Biol (1992) 1.28
A group of type I keratin genes on human chromosome 17: characterization and expression. Mol Cell Biol (1988) 1.27
The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells. J Cell Biol (1989) 1.25
Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations. J Cell Biol (1992) 1.18
Epidermal keratin filaments assembled in vitro have masses-per-unit-length that scale according to average subunit mass: structural basis for homologous packing of subunits in intermediate filaments. J Cell Biol (1983) 1.17
The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J Cell Biol (1993) 1.16
Sequence and expression of a type II keratin, K5, in human epidermal cells. Mol Cell Biol (1988) 1.15
Intermediate filaments. J Cell Biol (1984) 1.14
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat Struct Mol Biol (2012) 1.10
Complete sequence of a bovine type I cytokeratin gene: conserved and variable intron positions in genes of polypeptides of the same cytokeratin subfamily. EMBO J (1985) 1.10
The genetic basis of epidermolysis bullosa simplex with mottled pigmentation. Proc Natl Acad Sci U S A (1996) 1.08
Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton. Mol Biol Cell (1997) 1.07
Intermediate filaments in alpha-keratins. Proc Natl Acad Sci U S A (1986) 1.06
Secondary structure of component 8c-1 of alpha-keratin. An analysis of the amino acid sequence. Biochem J (1986) 1.05
Analysis of cytokeratin domains by cloning and expression of intact and deleted polypeptides in Escherichia coli. EMBO J (1987) 1.05
Intermediate filaments in muscle and epithelial cells of nematodes. J Cell Biol (1986) 1.04
The primary structure of component 8c-1, a subunit protein of intermediate filaments in wool keratin. Relationships with proteins from other intermediate filaments. Biochem J (1986) 1.02
Characterization of bovine keratin genes: similarities of exon patterns in genes coding for different keratins. EMBO J (1984) 1.01
Real-time observation of coiled-coil domains and subunit assembly in intermediate filaments. J Biol Chem (2002) 1.01
Structural characterization of human vimentin rod 1 and the sequencing of assembly steps in intermediate filament formation in vitro using site-directed spin labeling and electron paramagnetic resonance. J Biol Chem (2004) 1.00
Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity. J Cell Biol (1986) 1.00
Reconstitution of cytokeratin filaments in vitro: further evidence for the role of nonhelical peptides in filament assembly. J Cell Biol (1984) 0.99
Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted. J Cell Biol (1984) 0.97
A potential role for the COOH-terminal domain in the lateral packing of type III intermediate filaments. J Cell Biol (1991) 0.97
Characterization and regulation in the expression of a gene coding for the intermediate filament protein desmin. Proc Natl Acad Sci U S A (1984) 0.97
Intermediate filament cDNAs from BHK-21 cells: demonstration of distinct genes for desmin and vimentin in all vertebrate classes. Proc Natl Acad Sci U S A (1984) 0.97
Intermediate-sized filaments in Drosophila tissue culture cells. J Cell Biol (1984) 0.95
Expression of cytokeratin confers multiple drug resistance. Proc Natl Acad Sci U S A (1994) 0.95
Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res (1986) 0.95
Biotechnological Aspects and Perspective of Microbial Keratinase Production. Biomed Res Int (2015) 0.94
Amino acid sequences and homopolymer-forming ability of the intermediate filament proteins from an invertebrate epithelium. EMBO J (1988) 0.93
Intermediate filaments in non-neuronal cells of invertebrates: isolation and biochemical characterization of intermediate filaments from the esophageal epithelium of the mollusc Helix pomatia. J Cell Biol (1985) 0.93
Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization. Am J Pathol (1988) 0.93
A synthetic peptide representing the consensus sequence motif at the carboxy-terminal end of the rod domain inhibits intermediate filament assembly and disassembles preformed filaments. J Cell Biol (1992) 0.92
Sequence and expression of a human type II mesothelial keratin. J Cell Biol (1985) 0.92
Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. J Clin Invest (1994) 0.91
Site-directed spin labeling and electron paramagnetic resonance determination of vimentin head domain structure. J Biol Chem (2010) 0.89
Structural studies on lamin. Similarities and differences between lamin and intermediate-filament proteins. Biochem J (1986) 0.88
Sorting out IF networks: consequences of domain swapping on IF recognition and assembly. J Cell Biol (1991) 0.88
Clustered arrangement of keratin intermediate filament genes. Proc Natl Acad Sci U S A (1986) 0.87
Characterization of the linker 2 region in human vimentin using site-directed spin labeling and electron paramagnetic resonance. Biochemistry (2006) 0.87
The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography. J Biol Chem (2012) 0.86
Electron paramagnetic resonance analysis of the vimentin tail domain reveals points of order in a largely disordered region and conformational adaptation upon filament assembly. Protein Sci (2013) 0.79
Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic Ichthyosis. J Invest Dermatol (2015) 0.79
Identification of phosphorylation-induced changes in vimentin intermediate filaments by site-directed spin labeling and electron paramagnetic resonance. Biochemistry (2008) 0.79
Epidermal proteins. I. Differential extraction and quantitative polyacrylamide gel-electrophoretic analysis of basal spinous-cell proteins of neonatal mouse epidermis. Arch Dermatol Res (1985) 0.78
Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice. J Biol Chem (2014) 0.76
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa. Lancet (1993) 5.99
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell (2001) 5.01
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci (1997) 4.00
A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet (1999) 3.93
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61
Programming gene expression in developing epidermis. Development (1994) 3.60
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A (1998) 3.53
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31
The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell (1982) 3.08
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A (2001) 3.01
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell (1991) 2.98
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
Initiation of DNA-dependent RNA synthesis and the effect of heparin on RNA polymerase. Eur J Biochem (1967) 2.87
The expression of keratin genes in epidermis and cultured epidermal cells. Cell (1978) 2.87
Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev (1996) 2.82
The initiation of translation in E. coli: apparent base pairing between the 16srRNA and downstream sequences of the mRNA. Nucleic Acids Res (1990) 2.81
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell (1995) 2.75
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci (1996) 2.73
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med (1990) 2.50
Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A (1999) 2.37
Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev (2011) 2.37
Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. J Mol Biol (1983) 2.25
An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol (1987) 2.22
Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules. Cell (1979) 2.18
Actin dynamics and cell-cell adhesion in epithelia. Curr Opin Cell Biol (2001) 2.15
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol (1995) 2.06
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol (1986) 1.89
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol (2010) 1.85
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. J Cell Biol (1991) 1.80
Elucidating the early stages of keratin filament assembly. J Cell Biol (1990) 1.80
FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development (1999) 1.79
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev (1998) 1.78
Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78
Genetic and clinical mosaicism in a type of epidermal nevus. N Engl J Med (1994) 1.72
Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70
The downstream box: an efficient and independent translation initiation signal in Escherichia coli. EMBO J (1996) 1.70
Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci U S A (1991) 1.70
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy. Proc Natl Acad Sci U S A (1997) 1.68
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68
Unraveling the structure of the intermediate filaments. Cell (1983) 1.67
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein. Genes Dev (1994) 1.65
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev (1989) 1.62
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proc Natl Acad Sci U S A (1998) 1.61
An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development (2001) 1.60
Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol (1995) 1.60
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
Integrators of the cytoskeleton that stabilize microtubules. Cell (1999) 1.56
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation. J Cell Biol (1996) 1.55
High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiology (1993) 1.54
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci U S A (1985) 1.52
The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. Cell (1992) 1.51
Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro. J Cell Biol (1990) 1.49
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene (2006) 1.48
The transfection of epidermal keratin genes into fibroblasts and simple epithelial cells: evidence for inducing a type I keratin by a type II gene. Cell (1987) 1.47
Two signal model of lymphocyte activation. Immunol Today (1992) 1.46
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler (1986) 1.45
Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription. Genes Dev (1990) 1.42
Expandable esophageal stents: initial experience with a new nitinol stent. Gastrointest Endosc (1995) 1.42
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci U S A (1994) 1.42
Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex. Proc Natl Acad Sci U S A (1993) 1.41
The molecular biology of intermediate filament proteins. Int Rev Cytol (1992) 1.40
The importance of intramolecular ion pairing in intermediate filaments. Proc Natl Acad Sci U S A (1995) 1.40
Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.37
Isolation and characterization of the DNA replication complex from Escherichia coli. J Mol Biol (1970) 1.34
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
Differences in keratin synthesis between normal epithelial cells and squamous cell carcinomas are mediated by vitamin A. Proc Natl Acad Sci U S A (1984) 1.32