Published in Nat Genet on August 01, 1999
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol (2002) 5.51
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Epidermal barrier formation and recovery in skin disorders. J Clin Invest (2006) 4.14
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
KLF family members regulate intrinsic axon regeneration ability. Science (2009) 3.80
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med (2004) 3.69
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem (2000) 3.02
GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res (2005) 2.73
Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J Biol Chem (2001) 2.71
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol (2006) 2.59
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene (2005) 2.50
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays (2007) 2.40
The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J Cell Biol (2005) 2.36
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene (2011) 2.36
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34
Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res (2008) 2.30
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol (2000) 2.22
Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12
Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol (2003) 2.11
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol (2005) 2.11
Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene (2003) 2.11
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol (2003) 2.08
Transcriptional regulation of adipogenesis by KLF4. Cell Metab (2008) 2.07
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J Invest Dermatol (2009) 2.06
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol (2001) 1.93
Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J Immunol (2008) 1.83
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83
Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem (2010) 1.79
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai) (2008) 1.76
A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation. Dev Cell (2015) 1.76
Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity (2015) 1.75
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene (2001) 1.74
Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol (2003) 1.73
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71
Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett (2000) 1.70
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface (2007) 1.68
The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67
Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res (2002) 1.64
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res (2008) 1.64
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63
Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev (2004) 1.63
Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res (2000) 1.59
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol (2005) 1.57
KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. J Clin Invest (2014) 1.54
Role of Kruppel-like factors in leukocyte development, function, and disease. Blood (2010) 1.54
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell (2016) 1.49
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell (2012) 1.47
Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochem Biophys Res Commun (2009) 1.46
KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood (2005) 1.44
Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol (2007) 1.41
Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia (2011) 1.39
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood (2005) 1.39
KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia. Cancer Biol Ther (2005) 1.38
Psoriasis genetics: breaking the barrier. Trends Genet (2010) 1.38
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol (2006) 1.38
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. Nat Cell Biol (2009) 1.36
High-throughput chromatin information enables accurate tissue-specific prediction of transcription factor binding sites. Nucleic Acids Res (2008) 1.36
Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A (2006) 1.35
Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics (2007) 1.34
Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J Gastroenterol (2002) 1.34
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS One (2013) 1.33
12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol (2007) 1.32
Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31
Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res (2010) 1.29
The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development. EMBO J (2006) 1.25
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol (2008) 1.23
Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest (2006) 1.22
Kruppel-like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development. Development (2009) 1.20
Covering the limb--formation of the integument. J Anat (2003) 1.16
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15
Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation. J Neuroinflammation (2010) 1.15
Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Dev Biol (2010) 1.14
Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus. Gastroenterology (2010) 1.13
Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. Dev Biol (2006) 1.13
A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol (2011) 1.13
The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J (2009) 1.13
Krüppel-like family of transcription factors: an emerging new frontier in fat biology. Int J Biol Sci (2009) 1.12
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer. Gastroenterology (2010) 1.11
Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell (2008) 1.11
A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res (2014) 1.10
Kruppel-like factor 2 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol (2010) 1.09
Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3. J Invest Dermatol (2012) 1.09
Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea. Invest Ophthalmol Vis Sci (2008) 1.08
"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress. Antioxid Redox Signal (2011) 1.07
Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state. BMC Biol (2010) 1.07
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Nat Cell Biol (2011) 1.07
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. Cell Stem Cell (2013) 1.06
Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation. J Biol Chem (2010) 1.06
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation. Proc Natl Acad Sci U S A (2011) 1.05
Progenitor function in self-renewing human epidermis is maintained by the exosome. Cell Stem Cell (2012) 1.05
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