Non-neuronal functions of the m2 muscarinic acetylcholine receptor.

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Published in Genes (Basel) on April 02, 2013

Authors

Wymke Ockenga1, Sina Kühne2, Simone Bocksberger3, Antje Banning4, Ritva Tikkanen5

Author Affiliations

1: Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Wymke.Ockenga@biochemie.med.uni-giessen.de.
2: Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Sina.Kuehne@biochemie.med.uni-giessen.de.
3: Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Simonebocksberger@web.de.
4: Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Antje.Banning@biochemie.med.uni-giessen.de.
5: Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Ritva.Tikkanen@biochemie.med.uni-giessen.de.

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Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell (2006) 13.15

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03

Identification of a family of muscarinic acetylcholine receptor genes. Science (1987) 6.21

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature (1987) 6.05

G protein-coupled receptor kinases. Annu Rev Biochem (1998) 5.53

International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev (1998) 5.34

The Ras superfamily at a glance. J Cell Sci (2005) 4.83

ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J Cell Biol (1997) 4.76

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol (2000) 4.29

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature (1994) 4.05

Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol (2012) 3.92

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

A regulatory role for ARF6 in receptor-mediated endocytosis. Science (1995) 3.82

Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus. J Biol Chem (1994) 3.71

Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol (2001) 3.70

Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane. J Biol Chem (2003) 3.53

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol (2008) 3.39

ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol (2011) 3.38

PI(4,5)P(2) regulation of surface membrane traffic. Curr Opin Cell Biol (2001) 3.14

Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic (2004) 2.91

Signal characteristics of G protein-transactivated EGF receptor. EMBO J (1997) 2.88

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science (1997) 2.86

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol (2002) 2.76

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene (2001) 2.66

ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol (2002) 2.63

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J (1999) 2.63

Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals. Proc Natl Acad Sci U S A (2004) 2.61

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci (2001) 2.54

Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov (2002) 2.47

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem (2002) 2.42

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature (2001) 2.39

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J (1997) 2.39

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J Biol Chem (1995) 2.35

Ion channel regulation by G proteins. Physiol Rev (1995) 2.29

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) Nature (1999) 2.23

Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Mol Biol Cell (2004) 2.19

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene (2001) 2.12

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A (1998) 2.08

Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion. J Biol Chem (1992) 2.02

Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol (2005) 2.00

Myristoylation of ADP-ribosylation factor 1 facilitates nucleotide exchange at physiological Mg2+ levels. J Biol Chem (1995) 1.98

Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 1.93

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87

The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. J Biol Chem (1997) 1.86

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem (1995) 1.85

A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J Biol Chem (1998) 1.82

Two distinct members of the ADP-ribosylation factor family of GTP-binding proteins regulate cell-free intra-Golgi transport. Cell (1992) 1.80

Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res (2003) 1.75

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem (1994) 1.60

Localization and function of Arf family GTPases. Biochem Soc Trans (2005) 1.58

Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem (1999) 1.56

Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front Biosci (2004) 1.53

Expression and function of genes encoding cholinergic components in murine immune cells. Life Sci (2007) 1.53

G protein specificity: traffic direction required. Cell Signal (2002) 1.50

Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion. J Biochem (2003) 1.50

A role for ADP-ribosylation factor in nuclear vesicle dynamics. Nature (1992) 1.50

Update in Sjögren syndrome. Curr Opin Rheumatol (2000) 1.47

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J (2006) 1.46

Modulation of Rac1 and ARF6 activation during epithelial cell scattering. J Biol Chem (2003) 1.44

Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes (2004) 1.44

Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem (2002) 1.42

Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. EMBO J (1998) 1.41

Regulated exocytosis in chromaffin cells. Translocation of ARF6 stimulates a plasma membrane-associated phospholipase D. J Biol Chem (1998) 1.41

Endothelial cells cultured from human umbilical vein release ATP, substance P and acetylcholine in response to increased flow. Proc Biol Sci (1990) 1.35

The non-neuronal cholinergic system of human skin. Horm Metab Res (2007) 1.34

Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem (1997) 1.33

The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. EMBO J (1997) 1.32

Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem (1996) 1.32

Human keratinocytes synthesize, secrete, and degrade acetylcholine. J Invest Dermatol (1993) 1.29

Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin. J Biol Chem (1999) 1.29

Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res (2003) 1.28

G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circ Res (2004) 1.27

Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. J Biol Chem (1997) 1.27

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem (1996) 1.26

Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization. J Biol Chem (2005) 1.24

The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro. J Auton Pharmacol (2002) 1.23

Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clin Cancer Res (1999) 1.23

ERKI/II regulation by the muscarinic acetylcholine receptors in neurons. J Neurosci (2000) 1.23

Expression and distribution of cholinergic receptors in the human urothelium. Life Sci (2007) 1.20

Transfer of M2 muscarinic acetylcholine receptors to clathrin-derived early endosomes following clathrin-independent endocytosis. J Biol Chem (2002) 1.19

Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol (2009) 1.19

Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function. Life Sci (2012) 1.18

The epithelial cholinergic system of the airways. Histochem Cell Biol (2008) 1.17

G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells. J Biol Chem (2004) 1.17

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor expression and function. J Biol Chem (1990) 1.17

Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J Biol Chem (1995) 1.15

NICOTINIC AND MUSCARINIC RECEPTORS OF RENSHAW CELLS. Nature (1964) 1.14

Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors. Involvement of Gbetagamma and Galphaq/11 subunits. J Biol Chem (1997) 1.13

Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance. J Pharmacol Sci (2008) 1.12

Receptor subtypes or species homologues: relevance to drug discovery. Trends Pharmacol Sci (1993) 1.10

Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol (1991) 1.10

Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol (2000) 1.09

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J Biol Chem (1994) 1.08

Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation. J Biol Chem (2000) 1.07

M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system. Receptors Channels (2003) 1.05

Structure and activation of muscarinic acetylcholine receptors. Biochem Soc Trans (2003) 1.05