Published in J Biol Chem on December 27, 2001
Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer (2010) 11.16
Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol (2005) 3.48
Metabolism, cell surface organization, and disease. Cell (2009) 2.41
Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol (2010) 2.04
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci (2010) 1.82
Integrins and cell-fate determination. J Cell Sci (2009) 1.76
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65
Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res (2008) 1.63
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol (2006) 1.57
HGF-independent potentiation of EGFR action by c-Met. Oncogene (2011) 1.46
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res (2009) 1.44
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol (2004) 1.40
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell (2006) 1.32
Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol Biol Cell (2007) 1.28
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. J Biol Chem (2004) 1.28
Retracted Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol (2003) 1.26
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol (2008) 1.24
The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res (2008) 1.23
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell (2003) 1.16
Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways. Oncogene (2012) 1.11
Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol (2004) 1.11
Biochemical visualization of cell surface molecular clustering in living cells. Proc Natl Acad Sci U S A (2008) 1.08
Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Exp Eye Res (2007) 1.07
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc Natl Acad Sci U S A (2005) 1.06
Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP-dependent protein kinase A. Mol Biol Cell (2005) 1.06
The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. Mol Biol Cell (2008) 1.05
β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res (2011) 1.05
The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic (2010) 1.04
Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766. J Biol Chem (2012) 1.04
Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta (2013) 1.03
The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. Oncogene (2008) 1.02
The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling. Cell Microbiol (2011) 1.02
EGFR kinase regulates volume-sensitive chloride current elicited by integrin stretch via PI-3K and NADPH oxidase in ventricular myocytes. J Gen Physiol (2006) 1.01
PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma. J Oncol (2010) 1.01
The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. J Virol (2010) 1.01
β1 and β4 integrins: from breast development to clinical practice. Breast Cancer Res (2014) 1.00
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS One (2013) 0.98
{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation. J Cell Biol (2005) 0.97
Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53. Mol Cell Biol (2004) 0.97
Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite. PLoS Pathog (2013) 0.96
The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate. Mol Biol Cell (2004) 0.96
Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene (2009) 0.94
Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. J Cell Biochem (2009) 0.93
Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J (2006) 0.92
PAI-1 is a Critical Upstream Regulator of the TGF-beta1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma. J Biomed Biotechnol (2007) 0.92
Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells. J Biol Chem (2010) 0.91
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Mol Biol Cell (2011) 0.90
EGFR Signaling in Liver Diseases. Int J Mol Sci (2015) 0.90
The integrin alpha2beta1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production. Br J Pharmacol (2009) 0.89
Cellular functions regulated by phosphorylation of EGFR on Tyr845. Int J Mol Sci (2013) 0.89
Characterization of primary cilia in human airway smooth muscle cells. Chest (2009) 0.88
Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol (2011) 0.87
Integrin signalling and the cellular response to ionizing radiation. J Mol Histol (2004) 0.87
Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data. PLoS One (2012) 0.87
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase. Clin Cancer Res (2008) 0.86
Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. Neuro Oncol (2013) 0.85
Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability. PLoS One (2011) 0.84
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res (2012) 0.84
Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases. Infect Immun (2010) 0.83
Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation. J Biol Chem (2010) 0.83
Regulation of TGF-β1-Induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver. Front Physiol (2011) 0.83
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat Struct Mol Biol (2015) 0.83
β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer. Front Pharmacol (2015) 0.82
Mutual cross-talk between fibronectin integrins and the EGF receptor: Molecular basis and biological significance. Cell Logist (2012) 0.82
Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells. Infect Immun (2013) 0.82
Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression. Virchows Arch (2013) 0.81
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers. J Bone Oncol (2015) 0.80
Modulation of factors affecting optic nerve head astrocyte migration. Invest Ophthalmol Vis Sci (2010) 0.80
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem (2013) 0.79
Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells. Int J Mol Sci (2016) 0.78
Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival. PLoS One (2014) 0.78
P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation. PLoS One (2011) 0.78
Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers. Sci Rep (2017) 0.77
Tetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers. Sci Rep (2015) 0.77
Involvement of lipid rafts in adhesion-induced activation of Met and EGFR. J Biomed Sci (2011) 0.77
Characterization of crude Echis carinatus venom-induced cytotoxicity in HEK 293T cells. J Venom Res (2011) 0.77
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget (2016) 0.77
Nuclear lamins in cancer. Cell Mol Bioeng (2016) 0.76
Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking. Biophys J (2016) 0.75
Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection. MBio (2016) 0.75
High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers. Cancer Med (2016) 0.75
β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. PLoS Genet (2017) 0.75
Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells "in vitro" and correlating with progression "in vivo". Oncotarget (2016) 0.75
Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer. PLoS One (2016) 0.75
RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin. Oncogene (2016) 0.75
Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration. J Surg Res (2007) 0.75
N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4. Sci Rep (2016) 0.75
Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model. Clin Exp Nephrol (2017) 0.75
Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells. Exp Ther Med (2017) 0.75
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res (2005) 4.13
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell (2004) 3.87
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron (2009) 3.54
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science (2010) 3.21
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem (2003) 2.94
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med (2002) 2.89
p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol (2006) 2.84
EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature (2013) 2.70
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol (2009) 2.59
Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol (2003) 2.57
Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res (2006) 2.34
Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure (2009) 2.30
Assembly reflects evolution of protein complexes. Nature (2008) 2.27
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal (2008) 2.19
Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ Res (2002) 2.11
Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses. Clin Cancer Res (2009) 2.00
Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res (2008) 1.97
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res (2006) 1.92
p21-activated kinase regulates endothelial permeability through modulation of contractility. J Biol Chem (2004) 1.91
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem (2004) 1.86
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res (2002) 1.82
Prediction of human disease genes by human-mouse conserved coexpression analysis. PLoS Comput Biol (2008) 1.81
Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells (2008) 1.80
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration. J Cell Biol (2002) 1.78
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest (2005) 1.70
Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains. Mol Biol Cell (2005) 1.67
Efficacy of donkey's milk in treating highly problematic cow's milk allergic children: an in vivo and in vitro study. Pediatr Allergy Immunol (2007) 1.64
Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor. J Biol Chem (2002) 1.63
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche. Curr Opin Cell Biol (2012) 1.51
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin Cancer Res (2005) 1.50
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica (2010) 1.47
Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res (2006) 1.45
E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J Cell Sci (2005) 1.45
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling. Mol Biol Cell (2005) 1.45
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol (2005) 1.44
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43
TTP specifically regulates the internalization of the transferrin receptor. Cell (2005) 1.41
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest (2012) 1.36
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation (2013) 1.36
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development (2010) 1.36
Integrins and signal transduction. Adv Exp Med Biol (2010) 1.34
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood (2002) 1.34
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell (2005) 1.33
Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine (2012) 1.32
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem (2007) 1.31
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci U S A (2008) 1.31
Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior. Neurobiol Learn Mem (2006) 1.29
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci (2004) 1.29
Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem (2001) 1.28
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med (2005) 1.27
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. Am J Pathol (2008) 1.26
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence. Cardiovasc Res (2004) 1.25
A dynamic podosome-like structure of epithelial cells. Exp Cell Res (2004) 1.25
Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs. BMC Bioinformatics (2004) 1.25
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis. Mol Biol Cell (2005) 1.25
Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. Proc Natl Acad Sci U S A (2007) 1.25
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. J Cell Biol (2002) 1.23
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell (2013) 1.21
Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res (2005) 1.19
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell (2003) 1.16
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood (2005) 1.16
A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells (2010) 1.15
The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells. Hum Mol Genet (2008) 1.12
ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies. J Cell Sci (2006) 1.12
The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis. Pigment Cell Res (2005) 1.10