Published in Adv Biol Regul on April 19, 2014
MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. PLoS One (2015) 1.15
Retracted MicroRNA-302a functions as a putative tumor suppressor in colon cancer by targeting Akt. PLoS One (2014) 1.09
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov (2015) 1.02
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression. Front Immunol (2016) 0.83
The therapeutic potential of mTOR inhibitors in breast cancer. Br J Clin Pharmacol (2016) 0.83
Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells. Oncotarget (2015) 0.81
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer. Cell Mol Life Sci (2015) 0.80
Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1. BMB Rep (2015) 0.78
MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes. Oncotarget (2016) 0.78
Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Sci Rep (2016) 0.78
Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics (2015) 0.77
Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling. Oncotarget (2016) 0.76
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiol Rep (2016) 0.76
The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion. Cancers (Basel) (2015) 0.76
The Enigma of Rapamycin Dosage. Mol Cancer Ther (2016) 0.76
It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches. Mol Cell Neurosci (2017) 0.75
The inhibitory effect of PIK-75 on inflammatory mediator response induced by hydrogen peroxide in feline esophageal epithelial cells. Mediators Inflamm (2014) 0.75
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. J Neurotrauma (2016) 0.75
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes (2017) 0.75
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nat Commun (2017) 0.75
Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes. Adipocyte (2016) 0.75
Akt3 knockdown induces mitochondrial dysfunction in human cancer cells. Acta Biochim Biophys Sin (Shanghai) (2016) 0.75
Endosome and INPP4B. Oncotarget (2016) 0.75
How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5? World J Nephrol (2016) 0.75
Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2. Sci Rep (2017) 0.75
Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation. Acta Biomater (2017) 0.75
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) protects 661W cells against oxidative stress. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). Br J Cancer (2017) 0.75
Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid. Oncoimmunology (2016) 0.75
Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol (2017) 0.75
An in vitro model of renal inflammation after ischemic oxidative stress injury: nephroprotective effects of a hyaluronan ester with butyric acid on mesangial cells. J Inflamm Res (2017) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
mTOR signaling in growth control and disease. Cell (2012) 29.21
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
mTOR and cancer: insights into a complex relationship. Nat Rev Cancer (2006) 11.86
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature (2007) 10.98
PI3K pathway alterations in cancer: variations on a theme. Oncogene (2008) 9.94
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell (2005) 8.22
Role of translocation in the activation and function of protein kinase B. J Biol Chem (1997) 7.29
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell (1993) 6.44
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell (2007) 6.00
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol (2005) 5.00
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest (2003) 4.79
Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochim Biophys Acta (2004) 4.11
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem (2004) 4.01
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell (2005) 3.78
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res (2003) 3.30
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell (2008) 3.27
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res (2007) 3.13
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development (2005) 3.02
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res (2004) 2.84
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem (2003) 2.76
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A (2000) 2.48
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol (2012) 2.39
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal (2009) 2.38
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol (2002) 2.15
New insights into mTOR signaling: mTORC2 and beyond. Sci Signal (2009) 2.08
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor. Sci Signal (2011) 2.04
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol (2006) 2.03
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol (2006) 2.01
Introducing intermediate filaments: from discovery to disease. J Clin Invest (2009) 1.96
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem (2006) 1.94
Hitting the target: emerging technologies in the search for kinase substrates. Sci STKE (2002) 1.91
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal (2008) 1.81
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell (2014) 1.61
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Mol Cell (2010) 1.53
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res (2009) 1.53
PDK2: a complex tail in one Akt. Sci STKE (2001) 1.50
Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation. Cancer Res (2007) 1.44
Kinase phosphorylation: Keeping it all in the family. Curr Biol (1999) 1.32
The emerging multiple roles of nuclear Akt. Biochim Biophys Acta (2012) 1.25
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. Proc Natl Acad Sci U S A (2012) 1.22
Protein kinase B beta/Akt2 plays a specific role in muscle differentiation. J Biol Chem (2000) 1.21
Nuclear lamins and chromatin: when structure meets function. Adv Enzyme Regul (2008) 1.20
Akt1 contains a functional leucine-rich nuclear export sequence. Biochem Biophys Res Commun (2005) 1.15
The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival. Adv Enzyme Regul (2010) 1.14
Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol (2014) 1.12
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol (2005) 1.12
Discovery of a novel class of AKT pleckstrin homology domain inhibitors. Mol Cancer Ther (2008) 1.09
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression. FASEB J (2013) 1.06
Targeting Akt3 signaling in triple-negative breast cancer. Cancer Res (2013) 1.06
Structure, regulation, and pharmacological modulation of PP2A phosphatases. Methods Mol Biol (2013) 1.05
Targeting of the Akt/PKB kinase to the actin skeleton. Cell Mol Life Sci (2003) 1.03
Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells. J Proteome Res (2008) 1.02
Mitotic lamin disassembly is triggered by lipid-mediated signaling. J Cell Biol (2012) 1.00
Achieving specificity in Akt signaling in cancer. Adv Biol Regul (2012) 0.97
A-type lamins and signaling: the PI 3-kinase/Akt pathway moves forward. J Cell Physiol (2009) 0.96
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). Mol Biol Cell (2011) 0.95
The significance of PTEN's protein phosphatase activity. Adv Enzyme Regul (2008) 0.94
Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells. Biochem Biophys Res Commun (2006) 0.94
Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells. J Cell Sci (1999) 0.93
The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy. Trends Mol Med (2001) 0.91
Detection of cytoplasmic and nuclear functions of mTOR by fractionation. Methods Mol Biol (2012) 0.89
Phosphoinositide signalling in the nucleus. Adv Enzyme Regul (2010) 0.88
Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion. Exp Cell Res (2007) 0.86
Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism. J Biol Chem (2013) 0.86
Nuclear PI-PLCβ1: an appraisal on targets and pathology. Adv Biol Regul (2013) 0.85
Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS. Adv Biol Regul (2012) 0.83
Role of the C-terminal regulatory domain in the allosteric inhibition of PKB/Akt. Adv Biol Regul (2012) 0.78
Erythropoietin-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of phosphatidylinositol 3-kinase and intranuclear generation of phosphatidylinositol (3,4,5) trisphosphate. Cell Signal (2002) 0.78
Laminopathies and A-type lamin-associated signalling pathways. Adv Enzyme Regul (2009) 0.77
Akt-ing up on SRPK1: oncogene or tumor suppressor? Mol Cell (2014) 0.77
PI3K signaling in cancer: beyond AKT. Curr Opin Cell Biol (2017) 0.76