Published in PLoS Genet on May 15, 2014
Disrupting mitochondrial-nuclear coevolution affects OXPHOS complex I integrity and impacts human health. Genome Biol Evol (2014) 0.95
Mitochondrial DNA Variation in Human Radiation and Disease. Cell (2015) 0.93
Higher-order genetic interactions and their contribution to complex traits. Trends Genet (2014) 0.92
Mitochondrial-nuclear epistasis contributes to phenotypic variation and coadaptation in natural isolates of Saccharomyces cerevisiae. Genetics (2014) 0.90
Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys (2014) 0.86
Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila. Genetics (2016) 0.85
Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance. PLoS Comput Biol (2016) 0.84
Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds. Mol Syst Biol (2015) 0.81
Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics (2014) 0.81
Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions. PLoS Genet (2017) 0.80
Mitochondrial Involvement in Vertebrate Speciation? The Case of Mito-nuclear Genetic Divergence in Chameleons. Genome Biol Evol (2015) 0.79
A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase. Dis Model Mech (2015) 0.79
Acclimation and acute temperature effects on population differences in oxidative phosphorylation. Am J Physiol Regul Integr Comp Physiol (2015) 0.79
Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing. Heredity (Edinb) (2016) 0.77
The song of the old mother: reproductive senescence in female drosophila. Fly (Austin) (2014) 0.77
Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types. Mol Syst Biol (2015) 0.77
Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population. BMC Genet (2016) 0.76
Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila. Genetics (2016) 0.75
Preparation of Mitochondrial Enriched Fractions for Metabolic Analysis in Drosophila. J Vis Exp (2015) 0.75
Review: can diet influence the selective advantage of mitochondrial DNA haplotypes? Biosci Rep (2015) 0.75
Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Heredity (Edinb) (2016) 0.75
No effect of mitochondrial genotype on reproductive plasticity following exposure to a non-infectious pathogen challenge in female or male Drosophila. Sci Rep (2017) 0.75
Compatibility between mitochondrial and nuclear genomes correlates with the quantitative trait of lifespan in Caenorhabditis elegans. Sci Rep (2015) 0.75
The Genomic Architecture of Flowering Time Varies Across Space and Time in Mimulus guttatus. Genetics (2017) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet (2007) 12.62
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
Growing roles for the mTOR pathway. Curr Opin Cell Biol (2005) 11.66
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96
The plasticity of aging: insights from long-lived mutants. Cell (2005) 9.88
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
Calorie restriction--the SIR2 connection. Cell (2005) 6.51
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. Proc Biol Sci (1996) 4.44
Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A (2008) 4.43
The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta (1999) 4.40
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09
High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos (2004) 4.01
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A (2006) 3.97
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell (2009) 3.78
Mechanisms of ageing: public or private? Nat Rev Genet (2002) 3.49
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell (2008) 3.38
Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci (1999) 3.25
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab (2011) 3.23
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell (2008) 2.97
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev (2007) 2.75
Comparative genomics of mitochondrial DNA in Drosophila simulans. J Mol Evol (2000) 2.72
Estimation of multivariate frailty models using penalized partial likelihood. Biometrics (2000) 2.70
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun (2000) 2.65
Epistasis dominates the genetic architecture of Drosophila quantitative traits. Proc Natl Acad Sci U S A (2012) 2.59
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37
Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome. Am J Hum Genet (2010) 2.07
Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. Aging Cell (2005) 2.07
Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat Res (2004) 2.01
What regulates mitochondrial DNA copy number in animal cells? Trends Genet (2001) 1.81
The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev (2009) 1.79
Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech Ageing Dev (2005) 1.75
Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech Ageing Dev (2006) 1.73
Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup. J Mol Evol (2000) 1.66
The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. Genetics (2003) 1.63
A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Genetics (2002) 1.63
mTOR integrates amino acid- and energy-sensing pathways. Biochem Biophys Res Commun (2004) 1.54
Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PLoS One (2009) 1.53
DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion (2009) 1.50
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises development and fitness in Drosophila. PLoS Genet (2013) 1.41
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds. Genetics (2005) 1.31
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A (2008) 1.19
Mitochondrial-nuclear epistasis affects fitness within species but does not contribute to fixed incompatibilities between species of Drosophila. Evolution (2010) 1.14
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A (2012) 1.10
Identification of point mutations by mispairing PCR as exemplified in MERRF disease. Biochem Biophys Res Commun (1990) 1.03
Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner. Aging (Albany NY) (2013) 1.00
Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. Aging Cell (2009) 0.93
A novel mutation in the mitochondrial tRNA(TYr) gene associated with exercise intolerance. Neurology (2000) 0.86
CPEO associated with a single nucleotide deletion in the mitochondrial tRNA(Tyr) gene. Neurology (2001) 0.83
Fishing for adaptive epistasis using mitonuclear interactions. PLoS Genet (2017) 0.75