Published in Cell Cycle on May 14, 2014
Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med (2016) 1.17
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog (2015) 0.88
Targeting ubiquitination for cancer therapies. Future Med Chem (2015) 0.82
Epidermal growth factor signaling in transformed cells. Int Rev Cell Mol Biol (2014) 0.81
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation. J Immunol (2015) 0.78
E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med (2016) 0.76
Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling. Front Immunol (2015) 0.75
Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression. Sci Rep (2016) 0.75
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1. Int J Mol Sci (2016) 0.75
Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma. Oncotarget (2017) 0.75
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell (2000) 7.82
Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol (2004) 7.10
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38
The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol (1990) 5.36
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21
Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol (2001) 4.11
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature (2002) 3.99
Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89
The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem (2009) 3.86
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature (2014) 3.45
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature (2002) 2.99
The novel functions of ubiquitination in signaling. Curr Opin Cell Biol (2004) 2.93
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity (1998) 2.92
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature (1999) 2.82
Ubiquitin in chains. Trends Biochem Sci (2000) 2.82
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol (2002) 2.64
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol (2010) 2.58
Transcriptional regulation by histone ubiquitination and deubiquitination. Genes Dev (2003) 2.27
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med (2010) 2.17
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
Ubiquitin ligases and the immune response. Annu Rev Immunol (2004) 2.14
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon. Nat Immunol (2009) 2.12
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer (2011) 2.06
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J Biol Chem (2004) 1.69
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet (2002) 1.63
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell (2007) 1.60
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. J Immunol (2004) 1.50
RINGs hold the key to ubiquitin transfer. Trends Biochem Sci (2011) 1.50
Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J Biol Chem (2001) 1.50
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity (2000) 1.44
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood (2004) 1.43
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem (2006) 1.42
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem (2003) 1.41
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J Biol Chem (2000) 1.41
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nat Struct Mol Biol (2012) 1.40
Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol (2002) 1.39
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol (2011) 1.38
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem (2002) 1.36
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene (1995) 1.35
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proc Natl Acad Sci U S A (2009) 1.34
Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes (2007) 1.33
The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol (2002) 1.32
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Cancer Cell (2010) 1.31
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30
cbl-b inhibits epidermal growth factor receptor signaling. Oncogene (1999) 1.29
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest (2007) 1.29
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med (2007) 1.28
The ubiquitination code: a signalling problem. Cell Div (2007) 1.25
Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med (2003) 1.25
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene (2004) 1.24
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. J Biol Chem (1999) 1.23
E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med (2007) 1.22
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance. Arthritis Rheum (2002) 1.21
Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b. Proc Natl Acad Sci U S A (2011) 1.21
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol (2011) 1.18
A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem (2001) 1.17
Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol (2007) 1.16
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol (2004) 1.13
PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal (2009) 1.12
Beyond the RING: CBL proteins as multivalent adapters. Oncogene (2001) 1.11
Cbl and Cbl-b in T-cell regulation. Trends Immunol (2002) 1.11
Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood (2008) 1.10
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep (2012) 1.09
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem (2003) 1.08
The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol Today (1999) 1.08
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene (1997) 1.07
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res (2009) 1.07
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity (2007) 1.06
Cbl promotes clustering of endocytic adaptor proteins. Nat Struct Mol Biol (2005) 1.05
The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. J Biol Chem (2010) 1.02
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene (1999) 1.02
Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest (2010) 1.02
Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. J Biol Chem (2004) 1.01
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem (2006) 0.97
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood (2003) 0.97
c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. J Biol Chem (2011) 0.97
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors. Mol Cell Biol Res Commun (1999) 0.97
Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol (2005) 0.96
Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J Biol Chem (2003) 0.96
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells. J Immunol (2013) 0.96
Whole-exome sequencing of a pedigree segregating asthma. BMC Med Genet (2012) 0.95
Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity. J Immunol (2007) 0.95
Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunol Cell Biol (2011) 0.94
Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med (2002) 0.93
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. J Leukoc Biol (2005) 0.92
Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics. Mol Cell Biol (2012) 0.91
E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep (2014) 0.91