Published in Nature on March 14, 2002
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron (2006) 4.98
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell (2009) 3.42
Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest (2012) 2.02
The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci (2008) 2.00
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
The BAR domain proteins: molding membranes in fission, fusion, and phagy. Microbiol Mol Biol Rev (2006) 1.94
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Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90
Clathrin-dependent endocytosis. Biochem J (2004) 1.89
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. EMBO J (2002) 1.86
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Endophilin marks and controls a clathrin-independent endocytic pathway. Nature (2014) 1.69
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol (2004) 1.67
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Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest (2006) 1.66
Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci U S A (2003) 1.66
Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer. Histochem Cell Biol (2008) 1.65
Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol (2005) 1.65
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c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem (2007) 1.52
Intermolecular interactions of Sprouty proteins and their implications in development and disease. Mol Pharmacol (2009) 1.52
Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. J Clin Invest (2005) 1.50
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49
Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5. Mol Biol Cell (2006) 1.42
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc Natl Acad Sci U S A (2002) 1.40
Prediction of graft-versus-host disease in humans by donor gene-expression profiling. PLoS Med (2007) 1.40
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A (2002) 1.36
A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation. Mol Cell Biol (2008) 1.36
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol Biol Cell (2005) 1.35
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell (2004) 1.34
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Cancer Biol Ther (2011) 1.31
K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Immunity (2010) 1.30
MET as a target for treatment of chest tumors. Lung Cancer (2008) 1.29
Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalization. Traffic (2006) 1.24
Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein. J Biol Chem (2006) 1.23
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. Mol Cancer (2011) 1.22
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Ubiquitin binds to and regulates a subset of SH3 domains. Mol Cell (2007) 1.19
Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin. J Cell Biol (2007) 1.17
Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry (2009) 1.16
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A (2009) 1.16
c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem (2010) 1.15
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. EMBO J (2007) 1.14
CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. J Biol Chem (2010) 1.13
Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol (2014) 1.10
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J (2006) 1.09
Endosomal crosstalk: meeting points for signaling pathways. Trends Cell Biol (2012) 1.08
The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks. J Biol Chem (2013) 1.06
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Proc Natl Acad Sci U S A (2005) 1.05
Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med (2002) 1.05
A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. EMBO J (2010) 1.05
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol (2012) 1.03
Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells. J Cell Sci (2008) 1.02
Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. J Biol Chem (2004) 1.02
Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell (2004) 1.01
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem J (2003) 1.01
Up-regulation of ALG-2 in hepatomas and lung cancer tissue. Am J Pathol (2003) 1.01
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol (2010) 1.00
The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer. Breast Cancer Res (2002) 0.99
Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Proc Natl Acad Sci U S A (2003) 0.99
The MET axis as a therapeutic target. Update Cancer Ther (2009) 0.98
A multiscale computational approach to dissect early events in the Erb family receptor mediated activation, differential signaling, and relevance to oncogenic transformations. Ann Biomed Eng (2007) 0.97
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J (2011) 0.97
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep (2005) 0.97
Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol Cell Biol (2006) 0.97
Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitization. Cancer Res (2009) 0.96
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J (2010) 0.96
The developing story of Sprouty and cancer. Cancer Metastasis Rev (2014) 0.96
Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas. BMC Cancer (2009) 0.95
Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia. J Bone Miner Res (2009) 0.95
The Kaposi's sarcoma-associated herpesvirus K5 E3 ubiquitin ligase modulates targets by multiple molecular mechanisms. J Virol (2007) 0.95
Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons. Hum Mol Genet (2013) 0.94
Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci (Landmark Ed) (2009) 0.94
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance. Cell Signal (2010) 0.94
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. J Virol (2010) 0.94
Ubiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteins. Plant Physiol (2012) 0.93
MicroRNA-330 is an oncogenic factor in glioblastoma cells by regulating SH3GL2 gene. PLoS One (2012) 0.93
Signal transduction: molecular ticket to enter cells. Nature (2002) 0.92
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis. EMBO J (2013) 0.92
Regulation of developmental intercellular signalling by intracellular trafficking. EMBO J (2011) 0.91
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism. J Biol Chem (2010) 0.90
MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways. PLoS One (2014) 0.90
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem (2012) 0.90
Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. PLoS One (2010) 0.90
Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking. Nat Cell Biol (2011) 0.90
Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode. Nat Commun (2015) 0.89
Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection. J Virol (2008) 0.89
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci (2008) 0.88
Endocytosis and signaling during development. Cold Spring Harb Perspect Biol (2014) 0.87
hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cell Signal (2007) 0.87
Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol (2011) 0.87
An excellent monitoring system for surface ubiquitination-induced internalization in mammals. PLoS One (2008) 0.87
Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. Cell Signal (2007) 0.86
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. Cell Cycle (2014) 0.86
The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. Elife (2014) 0.86
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep (2008) 6.21
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell (2009) 5.76
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Ubiquitylation and cell signaling. EMBO J (2005) 4.65
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59
Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci (2003) 3.37
Targeting the ubiquitin system in cancer therapy. Nature (2009) 3.27
The Cbl interactome and its functions. Nat Rev Mol Cell Biol (2005) 3.27
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer (2006) 2.90
E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell (2007) 2.77
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem (2012) 2.53
Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol (2007) 2.30
Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol (2011) 2.15
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle (2009) 2.12
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02
Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood (2007) 1.99
Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell (2012) 1.94
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe (2012) 1.93
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev (2008) 1.92
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. EMBO J (2002) 1.86
What determines the specificity and outcomes of ubiquitin signaling? Cell (2010) 1.84
Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell (2010) 1.84
The role of ubiquitylation in receptor endocytosis and endosomal sorting. J Cell Sci (2012) 1.73
Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler Thromb Vasc Biol (2009) 1.70
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol (2004) 1.67
Generation and physiological roles of linear ubiquitin chains. BMC Biol (2012) 1.66
Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood (2008) 1.58
Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem Rev (2009) 1.56
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal (2009) 1.54
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J (2007) 1.51
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.49
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol (2012) 1.48
NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy (2009) 1.46
Signal processing by its coil zipper domain activates IKK gamma. Proc Natl Acad Sci U S A (2008) 1.46
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J (2012) 1.45
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proc Natl Acad Sci U S A (2010) 1.45
The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol (2011) 1.43
Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem (2003) 1.41
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc Natl Acad Sci U S A (2002) 1.40
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem (2004) 1.38
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem (2008) 1.37
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem (2002) 1.36
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell (2004) 1.34
The LC3 interactome at a glance. J Cell Sci (2013) 1.34
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proc Natl Acad Sci U S A (2009) 1.34
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Cancer Cell (2010) 1.31
Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J Cell Sci (2011) 1.30
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci (2012) 1.30
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol (2009) 1.29
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem (2012) 1.29
Compartmentalization of growth factor receptor signalling. Curr Opin Cell Biol (2005) 1.25
Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. Biol Chem (2010) 1.24
Mitochondria get a Parkin' ticket. Nat Cell Biol (2010) 1.22
Negative regulation of PTK signalling by Cbl proteins. Growth Factors (2005) 1.21
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci (2004) 1.20
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J Biol Chem (2012) 1.20
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol (2011) 1.18
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J (2005) 1.18
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. J Clin Invest (2004) 1.18
A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med (2003) 1.16
Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. J Mol Biol (2011) 1.11
Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J Biol Chem (2007) 1.11
Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol (2014) 1.10
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep (2012) 1.09
Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling. Blood (2012) 1.09
Ubiquitin networks in cancer. Curr Opin Genet Dev (2010) 1.06
TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep (2014) 1.06
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. Nat Immunol (2009) 1.06
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. Cell Signal (2008) 1.06
Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol Cell (2010) 1.05
Cbl promotes clustering of endocytic adaptor proteins. Nat Struct Mol Biol (2005) 1.05
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor. Oncogene (2003) 1.05
Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. Biochem J (2013) 1.03
Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J Biol Chem (2005) 1.03
Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. J Biol Chem (2004) 1.02
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr Biol (2010) 1.02
Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. Diabetes (2006) 1.02