Published in Science on April 14, 2006
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
CTCF: master weaver of the genome. Cell (2009) 15.09
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81
Chromosome territories. Cold Spring Harb Perspect Biol (2010) 5.00
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res (2009) 4.47
Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. EMBO J (2008) 4.28
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. J Cell Biol (2008) 3.13
Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster. Proc Natl Acad Sci U S A (2006) 3.06
Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc Natl Acad Sci U S A (2010) 3.03
Finding distal regulatory elements in the human genome. Curr Opin Genet Dev (2009) 3.02
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98
Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PLoS Biol (2009) 2.89
PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol (2008) 2.85
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J Exp Med (2008) 2.50
Condensin and cohesin complexity: the expanding repertoire of functions. Nat Rev Genet (2010) 2.49
Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet (2010) 2.49
Analysis of the H19ICR insulator. Mol Cell Biol (2007) 2.29
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol (2009) 2.20
Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus. Proc Natl Acad Sci U S A (2011) 2.15
Functional implications of genome topology. Nat Struct Mol Biol (2013) 2.13
Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol (2006) 2.12
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Res (2008) 2.10
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res (2012) 2.09
Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. Chromosome Res (2006) 2.07
Higher-order genome organization in human disease. Cold Spring Harb Perspect Biol (2010) 2.03
Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet (2006) 1.99
A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Rep (2013) 1.92
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell (2013) 1.91
Chromosome crosstalk in three dimensions. Nature (2009) 1.91
Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression. Mol Syst Biol (2008) 1.89
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev (2014) 1.85
ChIP-based methods for the identification of long-range chromatin interactions. J Cell Biochem (2009) 1.84
Chromatin dynamics and gene positioning. Cell (2008) 1.81
Nature and function of insulator protein binding sites in the Drosophila genome. Genome Res (2012) 1.77
The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Mol Cell Biol (2006) 1.75
IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev (2008) 1.73
CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. PLoS Genet (2008) 1.72
Chromatin dynamics. Annu Rev Biophys (2010) 1.70
Higher order chromatin structure at the X-inactivation center via looping DNA. Dev Biol (2008) 1.68
Cornelia de Lange syndrome, cohesin, and beyond. Clin Genet (2009) 1.68
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development. Genes Dev (2009) 1.68
Chromatin conformation signatures of cellular differentiation. Genome Biol (2009) 1.68
Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes. J Mol Evol (2008) 1.63
Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol (2011) 1.63
Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping. Cell (2015) 1.63
Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev (2008) 1.62
Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide. Mol Syst Biol (2010) 1.59
Chromatin loops in gene regulation. Biochim Biophys Acta (2008) 1.57
CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin. Chromosoma (2010) 1.56
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
Cis- and trans-acting elements regulate the mouse Psmb9 meiotic recombination hotspot. PLoS Genet (2007) 1.54
A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber. Proc Natl Acad Sci U S A (2011) 1.45
On the molecular etiology of Cornelia de Lange syndrome. Ann N Y Acad Sci (2009) 1.44
High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology. Nat Methods (2009) 1.44
Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. Dis Model Mech (2013) 1.42
Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site. PLoS One (2007) 1.40
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat Rev Cancer (2015) 1.40
Hematopoietic stem cell aging: mechanism and consequence. Exp Gerontol (2007) 1.39
The CTCF insulator protein is posttranslationally modified by SUMO. Mol Cell Biol (2008) 1.37
Active RNA polymerases: mobile or immobile molecular machines? PLoS Biol (2010) 1.37
The three-dimensional architecture of Hox cluster silencing. Nucleic Acids Res (2010) 1.36
Chromatin profiling of Epstein-Barr virus latency control region. J Virol (2007) 1.34
Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages. Nucleic Acids Res (2012) 1.32
Transcriptional control of the TNF gene. Curr Dir Autoimmun (2010) 1.32
A view of nuclear Polycomb bodies. Curr Opin Genet Dev (2011) 1.31
The role of CTCF in regulating nuclear organization. J Exp Med (2008) 1.30
Study of the functional interaction between Mcp insulators from the Drosophila bithorax complex: effects of insulator pairing on enhancer-promoter communication. Mol Cell Biol (2007) 1.29
Coactivator function defines the active estrogen receptor alpha cistrome. Mol Cell Biol (2009) 1.29
Long-range communication between the silencers of HMR. Mol Cell Biol (2008) 1.28
Interchromosomal association and gene regulation in trans. Trends Genet (2010) 1.26
CTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus. Mol Cell Biol (2010) 1.26
Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation. J Biol Chem (2012) 1.25
3D shortcuts to gene regulation. Curr Opin Cell Biol (2010) 1.25
Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes. EMBO J (2008) 1.24
Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells. Nat Immunol (2008) 1.24
Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome. PLoS One (2012) 1.23
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun (2009) 1.21
A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics (2011) 1.20
Organization of transcription. Cold Spring Harb Perspect Biol (2010) 1.20
Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO J (2006) 1.19
Thermodynamic pathways to genome spatial organization in the cell nucleus. Biophys J (2009) 1.18
Activation-dependent intrachromosomal interactions formed by the TNF gene promoter and two distal enhancers. Proc Natl Acad Sci U S A (2007) 1.18
HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination. Genome Res (2009) 1.17
Genome-wide mechanisms of nuclear receptor action. Trends Endocrinol Metab (2009) 1.16
Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformation. PLoS Pathog (2011) 1.16
Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions. J Biol Chem (2009) 1.15
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
EBV latency types adopt alternative chromatin conformations. PLoS Pathog (2011) 1.15
The evolution of epigenetic regulators CTCF and BORIS/CTCFL in amniotes. PLoS Genet (2008) 1.14
Gene positioning. Cold Spring Harb Perspect Biol (2010) 1.12
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. J Cell Biol (2011) 1.12
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol (2006) 6.11
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2011) 4.73
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science (2013) 4.60
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Rate-gyro-integral constraint for ambiguity resolution in GNSS attitude determination applications. Sensors (Basel) (2013) 4.22
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet (2013) 3.83
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A (2009) 3.57
Terminal 22q deletion syndrome: a newly recognized cause of speech and language disability in the autism spectrum. Pediatrics (2004) 3.48
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet (2008) 3.33
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet (2008) 3.14
A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res (2009) 2.86
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc Natl Acad Sci U S A (2011) 2.83
Membrane transformation during malaria parasite release from human red blood cells. Curr Biol (2005) 2.53
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum Vaccin (2010) 2.36
Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am J Hum Genet (2009) 2.33
Is it time to sound an alarm about false-positive cell-free DNA testing for fetal aneuploidy? Am J Obstet Gynecol (2013) 2.33
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging. Arch Gen Psychiatry (2010) 2.21
Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med (2007) 2.16
Vitamin D deficiency in older men. J Clin Endocrinol Metab (2009) 2.13
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol (2008) 2.12
Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer. Neoplasia (2008) 2.07
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02
Effects of Early Hypertension Control after Ischaemic Stroke on the Outcome: A Meta-Analysis. Cerebrovasc Dis (2015) 2.02
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Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet (2011) 1.88
Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am J Psychiatry (2008) 1.86
Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res (2007) 1.83
Systematic review: the effects of growth hormone on athletic performance. Ann Intern Med (2008) 1.78
Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS study. Urology (2006) 1.75
Choroidal thickness in healthy Chinese subjects. Invest Ophthalmol Vis Sci (2011) 1.74
Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study. Arch Intern Med (2009) 1.71
IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. J Biol Chem (2004) 1.65
Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab (2011) 1.64
Evaluation of Her-2/neu status in carcinomas with amplified chromosome 17 centromere locus. Am J Clin Pathol (2006) 1.62
Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives. Am J Med Genet B Neuropsychiatr Genet (2007) 1.59
Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse. Hum Mol Genet (2004) 1.58
Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer (2006) 1.58
Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Hum Mol Genet (2003) 1.54
Using electronic drug monitor feedback to improve adherence to antiretroviral therapy among HIV-positive patients in China. AIDS Behav (2010) 1.53
Clinical outcomes of two different types of open-door laminoplasties for cervical compressive myelopathy: a prospective study. Neurol India (2012) 1.53
Sex hormones and the risk of incident prostate cancer. Urology (2010) 1.52
Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming. Cell Stem Cell (2013) 1.52
The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab (2009) 1.52
Anterior decompression and nonstructural bone grafting and posterior fixation for cervical facet dislocation with traumatic disc herniation. Spine (Phila Pa 1976) (2012) 1.51
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol (2004) 1.49
A model for the preferential delivery of isoflurane to the spinal cord of the goat. Vet J (2010) 1.48
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia. PLoS One (2013) 1.47
δ opioid receptor antagonist, ICI 174,864, is suitable for the early treatment of uncontrolled hemorrhagic shock in rats. Anesthesiology (2013) 1.45
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. Diabetes (2011) 1.44
Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study. J Bone Miner Res (2010) 1.40
Two-stage vertebral column resection for severe and rigid scoliosis in patients with low body weight. Spine J (2012) 1.39
Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing. Proc Natl Acad Sci U S A (2009) 1.37
Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res (2003) 1.36
A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.36
Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res (2010) 1.35
Importance of dose timing to achieving undetectable viral loads. AIDS Behav (2009) 1.35
Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene. Cancer (2010) 1.34
Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers. Genes Chromosomes Cancer (2007) 1.32
Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI. Neuroimage (2009) 1.30
Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One (2011) 1.30
A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection. Radiother Oncol (2012) 1.27
WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim Biophys Acta (2008) 1.27
HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. Appl Immunohistochem Mol Morphol (2012) 1.27
Occupational exposure to blood and body fluids among health care workers in a general hospital, China. Am J Ind Med (2009) 1.27
A fine physical map of the rice chromosome 4. Genome Res (2002) 1.26
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry (2007) 1.25
Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration. Hum Gene Ther (2006) 1.25
Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther (2003) 1.25
Divergent patterns of telomere maintenance mechanisms among human sarcomas: sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas. Genes Chromosomes Cancer (2004) 1.24
A meta-analysis comparing the results of cervical disc arthroplasty with anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic cervical disc disease. J Bone Joint Surg Am (2013) 1.24
A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma. J Clin Invest (2003) 1.23
Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. J Am Geriatr Soc (2011) 1.23
Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. Biomaterials (2009) 1.23
Whole-genome array-CGH identifies novel contiguous gene deletions and duplications associated with developmental delay, mental retardation, and dysmorphic features. Am J Med Genet A (2007) 1.23
IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Mol Hum Reprod (2005) 1.22
Mortality risk in older men associated with changes in weight, lean mass, and fat mass. J Am Geriatr Soc (2011) 1.22
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. J Clin Invest (2010) 1.21
Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly. Am J Med (2004) 1.21
Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus. J Cell Biol (2014) 1.20
The histone code regulating expression of the imprinted mouse Igf2r gene. Endocrinology (2003) 1.20
Optimized clinical performance of growth hormone with an expanded genetic code. Proc Natl Acad Sci U S A (2011) 1.20
Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China. J Clin Endocrinol Metab (2011) 1.19
Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO J (2006) 1.19