Published in Methods Mol Biol on January 01, 2014
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci (2003) 3.79
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Intramembrane proteolysis: theme and variations. Science (2004) 3.06
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
SnapShot: notch signaling pathway. Cell (2007) 1.63
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell (2005) 1.62
Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell (2004) 1.62
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med (2004) 1.60
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (2012) 1.29
Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (2009) 1.23
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci (2010) 1.21
rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol (2008) 1.21
Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun (2006) 1.21
The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int (2005) 1.20
A garden of Notch-ly delights. Development (2006) 1.19
Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci (2006) 1.17
Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Dev Biol (2003) 1.15
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest (2013) 1.13
Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol (2005) 1.13
The Notch transcription activation complex makes its move. Cell (2006) 1.12
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (2011) 1.10
Notch pathway is dispensable for adipocyte specification. Genesis (2004) 1.08
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev (2009) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Rep (2013) 1.06
Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal (2011) 1.05
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci (2005) 1.04
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci (2009) 1.04
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet (2012) 1.02
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. J Neurochem (2005) 1.02
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. J Biol Chem (2009) 1.00
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One (2012) 0.98
Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A (2007) 0.93
Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol (2010) 0.91
Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res (2009) 0.91
The black box illuminated: signals and signaling. J Invest Dermatol (2011) 0.88
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (2013) 0.87
Epidermal ADAM17 is dispensable for notch activation. J Invest Dermatol (2013) 0.86
Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation (2009) 0.86
Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer Cell (2013) 0.85
In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS One (2013) 0.84
The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol (2013) 0.83
Chromatin-based mechanisms of renal epithelial differentiation. J Am Soc Nephrol (2011) 0.79
Murine vibrissae cultured in serum-free medium reinitiate anagen. J Invest Dermatol (2007) 0.78
Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harb Protoc (2010) 0.77
Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Curr Opin Genet Dev (2002) 0.76
Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays. Methods Mol Biol (2014) 0.76
A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry (2006) 0.75
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest (2016) 0.75
Making new kidneys: On the road from science fiction to science fact. Curr Opin Organ Transplant (2016) 0.75
Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium. Nat Commun (2016) 0.75
Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS). Cold Spring Harb Protoc (2015) 0.75
SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers. Mol Cell (2016) 0.75