Published in Dev Biol on November 13, 2009
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis. J Am Soc Nephrol (2012) 1.65
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (2011) 1.10
Notch in the kidney: development and disease. J Pathol (2011) 1.08
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet (2012) 1.02
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02
Renal anomalies in Alagille syndrome: a disease-defining feature. Am J Med Genet A (2011) 0.99
Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. J Biol Chem (2011) 0.98
WT1 and kidney progenitor cells. Organogenesis (2010) 0.97
Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol (2010) 0.91
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (2013) 0.87
Organ In Vitro Culture: What Have We Learned about Early Kidney Development? Stem Cells Int (2015) 0.85
Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One (2012) 0.84
Membrane trafficking in podocyte health and disease. Pediatr Nephrol (2012) 0.84
Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development (2015) 0.80
Chromatin-based mechanisms of renal epithelial differentiation. J Am Soc Nephrol (2011) 0.79
Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatr Nephrol (2013) 0.78
Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS Biol (2016) 0.78
Notch signaling promotes nephrogenesis by downregulating Six2. Development (2016) 0.78
Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol (2017) 0.75
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
The cellular basis of kidney development. Annu Rev Cell Dev Biol (2006) 4.57
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J (2006) 3.26
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol (2007) 2.48
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J (2002) 2.26
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 2.21
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity (2003) 2.03
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Regulation of lymphocyte development by Notch signaling. Nat Immunol (2007) 1.96
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol (2009) 1.84
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med (2007) 1.73
The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. Biochemistry (1999) 1.51
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. J Biol Chem (2008) 1.45
Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol (2005) 1.43
Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development (2003) 1.40
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis. Gene Expr Patterns (2004) 1.36
Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol (2007) 1.35
Molecular insights into segmentation along the proximal-distal axis of the nephron. J Am Soc Nephrol (2007) 1.34
Universal PCR genotyping assay that achieves single copy sensitivity with any primer pair. Transgenic Res (2003) 1.27
Alagille syndrome and the Jagged1 gene. Semin Liver Dis (2001) 1.17
Central nervous system myelination in mice with deficient expression of Notch1 receptor. J Neurosci Res (2002) 1.12
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc Natl Acad Sci U S A (2007) 1.11
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn (2008) 0.96
Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage. Am J Hum Genet (2003) 0.96
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP. Genesis (2007) 0.93
Intrinsic fluctuations, robustness, and tunability in signaling cycles. Biophys J (2007) 0.92
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci (2003) 3.79
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Intramembrane proteolysis: theme and variations. Science (2004) 3.06
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
SnapShot: notch signaling pathway. Cell (2007) 1.63
Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell (2004) 1.62
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell (2005) 1.62
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med (2004) 1.60
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol (2006) 1.34
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development (2012) 1.29
Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (2009) 1.23
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci (2010) 1.21
rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol (2008) 1.21
Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun (2006) 1.21
The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int (2005) 1.20
A garden of Notch-ly delights. Development (2006) 1.19
Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci (2006) 1.17
Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Dev Biol (2003) 1.15
Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest (2013) 1.13
Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol (2005) 1.13
The Notch transcription activation complex makes its move. Cell (2006) 1.12
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (2011) 1.10
CITED1 expression in Wilms' tumor and embryonic kidney. Neoplasia (2007) 1.10
Notch pathway is dispensable for adipocyte specification. Genesis (2004) 1.08
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev (2009) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Rep (2013) 1.06
Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal (2011) 1.05
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci (2009) 1.04
The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci (2005) 1.04
Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. Cancer Biol Ther (2005) 1.04
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol (2005) 1.03
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
Recent structural alteration of the peripheral lamina cribrosa near the location of disc hemorrhage in glaucoma. Invest Ophthalmol Vis Sci (2014) 1.03
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet (2012) 1.02
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. J Neurochem (2005) 1.02
Regulation of histone deacetylase 4 expression by the SP family of transcription factors. Mol Biol Cell (2005) 1.02
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. J Biol Chem (2009) 1.00
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One (2012) 0.98
Functional conservation of Notch1 and Notch2 intracellular domains. FASEB J (2005) 0.98
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn (2008) 0.96
Antibiotic resistance and assessment of food-borne pathogenic bacteria in frozen foods. Arch Pharm Res (2010) 0.95
Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A (2007) 0.93
Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field. Development (2009) 0.92
Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol (2010) 0.91
Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res (2009) 0.91
Relationship of intraocular pressure and frequency of spontaneous retinal venous pulsation in primary open-angle glaucoma. Ophthalmology (2012) 0.90
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture. J Immunol (2011) 0.90
The black box illuminated: signals and signaling. J Invest Dermatol (2011) 0.88
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (2013) 0.87
Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation (2009) 0.86
Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1. J Pediatr Surg (2007) 0.86
Epidermal ADAM17 is dispensable for notch activation. J Invest Dermatol (2013) 0.86
Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch? Cancer Cell (2013) 0.85
In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS One (2013) 0.84
Modulation of the anti-cancer efficacy of microtubule-targeting agents by cellular growth conditions. Cancer Biol Ther (2010) 0.84
Guided resonances in asymmetrical GaN photonic crystal slabs observed in the visible spectrum. Opt Express (2005) 0.84
Glucocorticoids modulate NF-kappaB-dependent gene expression by up-regulating FKBP51 expression in Newcastle disease virus-infected chickens. Mol Cell Endocrinol (2007) 0.84
Comparison of the antimelanogenic effects of p-coumaric acid and its methyl ester and their skin permeabilities. J Dermatol Sci (2011) 0.83
The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol (2013) 0.83
High-power room-temperature continuous-wave mid-infrared interband cascade lasers. Opt Express (2012) 0.82
Generation of mice that conditionally express the activation domain of Notch2. Genesis (2009) 0.81